NCT04069767

Brief Summary

The current study has the potential to improve rehabilitation during the subacute phase of a stroke, aiming to reduce the individual's disabilities and risk of falling, enhance health promoting physical activity and independence in ADL.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2019

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 23, 2019

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 28, 2019

Completed
12 days until next milestone

Study Start

First participant enrolled

September 9, 2019

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 5, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 5, 2021

Completed
Last Updated

September 28, 2022

Status Verified

April 1, 2022

Enrollment Period

2.2 years

First QC Date

August 23, 2019

Last Update Submit

September 27, 2022

Conditions

Keywords

PhysiotherapyRehabilitationTrunk StabilityStrokeSub-acuteInnovativeRandomized controlled trialQualitative studyGaitBalance

Outcome Measures

Primary Outcomes (2)

  • Trunk Impairment Scale Norwegian Version

    Validated scale to assess dynamic sitting balance. The test consists of ordinal 6 sub scales summed to measure dynamic sitting balance and trunk coordination.The scale ranges from 0-16 points where higher score indicates better sitting balance

    12 weeks

  • ActiGraph WgtX-BT

    Accelerometer recording levels of physical activity and number of steps

    13 weeks

Secondary Outcomes (8)

  • Swedish Postural Assessment Scale For Stroke Norwegian Version

    12 weeks

  • MiniBESTest

    12 weeks

  • Bodyfitter seat sensor system

    12 weeks

  • Amti Force Platform

    12 weeks

  • 10 meter walk test

    12 weeks

  • +3 more secondary outcomes

Study Arms (2)

ICoreDIST

EXPERIMENTAL

The intervention starts with an assessment by the physiotherapist to identify the patient's movement problems in order to choose among the 48 exercises in the intervention. Each session lasts for 60 minutes + exercises 5-10 minutes outside of therapy and is performed 5-6 days/per week in the rehabilitation units, and 3 sessions/week + home exercises 30 minutes 3 days per week in home based or outpatient treatment during the 12 weeks period.To allow for individualisation, each exercise contains five levels of difficulty. All exercises demand enhancement of dynamic trunk stability and functional movements.

Procedure: ICoreDIST

Standard Care

ACTIVE COMPARATOR

Consists of standard inpatient rehabilitation, home-based and outpatient-based physiotherapy with the same dose as the intervention group.

Procedure: Standard Care

Interventions

ICoreDISTPROCEDURE

The intervention consists of exercises that demand enhancement of dynamic trunk stability and functional movements, combined with the following: 1. Optimised alignment and adaptation to the base of support and often using an unstable reference point for the trunk (therapeutic ball) or the distal body parts. 2. Enhanced somatosensory integration of hands, feet and face, including reduced influence of vision to enhance somatosensory integration. 3. Proximal stability prior to selective task-oriented movement of limbs, head, eyes. 4. Inclusion of dual tasks (motor/motor and motor/cognitive) in exercises and activities such as walking indoors, out-doors and climbing stairs. 5. Specific hands-on interactions or other adaptations to optimise alignment and neuromuscular recruitment. 6. Exercises combining core activation and moderate increase in heart rate: in lying, sitting, standing and walking.

ICoreDIST
Standard CarePROCEDURE

According to national guidelines for stroke care, every patient in Norway will receive in-patient rehabilitation, home-based and out-patient based physiotherapy.

Standard Care

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • A stroke diagnosis
  • Can sit for 10 seconds without support
  • Age 18-85
  • Trunk Impairment Scale-Norwegian version (TIS-NV) \< 15
  • Pre-stroke modified Ranking Scale (mRS) 0-3

You may not qualify if:

  • Dementia
  • Unable to cooperate in physiotherapy
  • On-going substance abuse
  • Severe co-morbidity preventing rehabilitation, severe neurological diseases such as Parkinson disease, Multiple Sclerosis and brain tumor.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Nordlandssykehuset HF

Bodø, 8009, Norway

Location

Sykehuset Levanger

Levanger, 7600, Norway

Location

Related Publications (2)

  • Normann B, Arntzen EC, Sivertsen M. Comprehensive core stability intervention and coordination of care in acute and subacute stroke rehabilitation-a pilot study. European Journal of Physiotherapy; DOI: 10.1080/21679169.2018.1508497, 2018.

    BACKGROUND
  • Saunders DH, Mead GE, Fitzsimons C, Kelly P, van Wijck F, Verschuren O, Backx K, English C. Interventions for reducing sedentary behaviour in people with stroke. Cochrane Database Syst Rev. 2021 Jun 29;6(6):CD012996. doi: 10.1002/14651858.CD012996.pub2.

MeSH Terms

Conditions

Ischemic StrokeHemorrhagic StrokeStroke

Interventions

Standard of Care

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Quality Indicators, Health CareQuality of Health CareHealth Services AdministrationHealth Care Quality, Access, and Evaluation

Study Officials

  • Petter Øien

    Nordlandssykehuset HF

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: This is a parallel trial. After baseline assessment, the participants will be randomly assigned to one of two trial arms, A and B, in a 1:1 ratio.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 23, 2019

First Posted

August 28, 2019

Study Start

September 9, 2019

Primary Completion

December 5, 2021

Study Completion

December 5, 2021

Last Updated

September 28, 2022

Record last verified: 2022-04

Data Sharing

IPD Sharing
Will not share

Locations