Emotional Proactive Brain Study in Adults With Autism Spectrum Condition

NCT04069676 | Completed

• 2 other identifiers: 38RC19.1312019-A01145-52
• Study Type: observational
• Target: 94
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims:

• to study behavioral and cerebral activity specificity (latency and amplitude of evoked potentials, time frequency maps and cerebral connectivity) in predictive process (top-down regulation) during visual recognition of static and dynamic stimuli in adults participants with autism spectrum conditions compared to typically developed participants.
• to study the relation between predictive process and autonomous response (heart activity and electrodermal activity)
• to explore potential sex differences between autistic males and females

Conditions

Autism Spectrum Disorder

Keywords

Autism Spectrum Condition; predictive coding; visual perception; electroencephalography; autonomous nervous system; heart rate variability; electrodermal reactivity

Outcome Measures

Primary Outcomes (2)

• Differences between autistic and typically developed participants in evoked potentials related to prediction mechanisms during visual processing

  \- differences in evoked potentials (latency and amplitude) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity.

  55 minutes recording

• Differences between autistic and typically developed participants in behavioral responses related to prediction mechanisms during visual processing

  \- differences in behavioral responses (reaction time and correct response rate) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding behavioral response.

  55 minutes (same recording as before)

Secondary Outcomes (4)

• Differences between groups in oscillatory activity

  55 minutes (same record as before)

• Difference between groups in cerebral connectivity

  55 minutes (same record as before)

• Differences between groups in autonomous activity

  55 minutes (same record as before)

• Sex differences

  55 minutes (same record as before)

Study Arms (2)

Autism Spectrum Condition (ASC)

Adults males and females with a formal autism diagnosis, without intellectual disability

Other: EEG

Typically developped (TD)

Adults males and females without any neurodevelopemental issue (or health issue which could impaired task performances)

Other: EEG

Interventions

EEG OTHER

EEG, ECG and EDR record during a behavioral task

Also known as: ECG, EDR

Autism Spectrum Condition (ASC); Typically developped (TD)

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adults autistic males and females without intellectual disability compared to a control group

You may qualify if:

• affiliation to the french social protection care
• information and non opposition of the participant
• information and non opposition of tutor/curator if the case presented
• normal or corrected to normal vision
• capacity to understand and apply instruction required by the task
• no participation in another research
• for autistic person: formal diagnosis of autism spectrum condition (autism/asperger/PDD-NS) according to CIM-10/DSM-IV/DSM-5 criteria

You may not qualify if:

• adults with no ability to express their consent
• adults on judiciary protection
• perceptive/motor/neurological/psychiatric issue
• major health issue (cardiac, metabolic ...)
• alcohol or drug consumption

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• Laboratoire de Psychologie et NeuroCognition: collaborator

Study Sites (1)

Chu Grenoble Alpes

Grenoble, 38043, France

Location

Related Publications (7)

• Bar M. The proactive brain: using analogies and associations to generate predictions. Trends Cogn Sci. 2007 Jul;11(7):280-9. doi: 10.1016/j.tics.2007.05.005. Epub 2007 Jun 4.

  PMID: 17548232 BACKGROUND

• Caplette L, Wicker B, Gosselin F. Atypical Time Course of Object Recognition in Autism Spectrum Disorder. Sci Rep. 2016 Oct 18;6:35494. doi: 10.1038/srep35494.

  PMID: 27752088 BACKGROUND

• Gomot M, Wicker B. A challenging, unpredictable world for people with autism spectrum disorder. Int J Psychophysiol. 2012 Feb;83(2):240-7. doi: 10.1016/j.ijpsycho.2011.09.017. Epub 2011 Oct 1.

  PMID: 21968196 BACKGROUND

• Peyrin C, Michel CM, Schwartz S, Thut G, Seghier M, Landis T, Marendaz C, Vuilleumier P. The neural substrates and timing of top-down processes during coarse-to-fine categorization of visual scenes: a combined fMRI and ERP study. J Cogn Neurosci. 2010 Dec;22(12):2768-80. doi: 10.1162/jocn.2010.21424.

  PMID: 20044901 BACKGROUND

• Quintana DS, Guastella AJ, Outhred T, Hickie IB, Kemp AH. Heart rate variability is associated with emotion recognition: direct evidence for a relationship between the autonomic nervous system and social cognition. Int J Psychophysiol. 2012 Nov;86(2):168-72. doi: 10.1016/j.ijpsycho.2012.08.012. Epub 2012 Aug 30.

  PMID: 22940643 BACKGROUND

• Sinha P, Kjelgaard MM, Gandhi TK, Tsourides K, Cardinaux AL, Pantazis D, Diamond SP, Held RM. Autism as a disorder of prediction. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15220-5. doi: 10.1073/pnas.1416797111. Epub 2014 Oct 6.

  PMID: 25288765 BACKGROUND

• Thayer JF, Ahs F, Fredrikson M, Sollers JJ 3rd, Wager TD. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev. 2012 Feb;36(2):747-56. doi: 10.1016/j.neubiorev.2011.11.009. Epub 2011 Dec 8.

  PMID: 22178086 BACKGROUND

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Laurent Vercueil, Doctor

  University Hospital, Grenoble

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 23, 2019
• First Posted: August 28, 2019
• Study Start: September 17, 2020
• Primary Completion: July 12, 2021
• Study Completion: July 12, 2021
• Last Updated: May 9, 2022

Record last verified: 2022-05

Locations

FR (1)