NCT04068701

Brief Summary

Even though females are 2- to 10-times more likely to suffer an anterior cruciate ligament (ACL) injury, males represent the largest population of total ACL injuries. Consequently, there is a larger population of males that endure significant pain, functional limitations, and radiographic signs of knee osteoarthritis (OA) within 12 to 20 years of injury. To reduce the burden of OA, The National Public Health Agenda for Osteoarthritis recommends expanding and refining evidence-based prevention of ACL injury. Specialized training that targets modifiable risk factors shows statistical efficacy in high-risk athletes; however, clinically meaningful reduction of risk has not been achieved. A critical barrier that limits successful training outcomes is the requirement of qualified instructors to deliver personalized, intuitive, and accessible feedback to young athletes. Thus, a key gap in knowledge is how to efficiently deliver objective, effective feedback during training for injury prevention. The investiagator's long-term goal is to reduce ACL injuries and the subsequent sequela in young male athletes.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
380

participants targeted

Target at P75+ for not_applicable

Timeline
6mo left

Started Sep 2021

Longer than P75 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress90%
Sep 2021Dec 2026

First Submitted

Initial submission to the registry

May 24, 2019

Completed
3 months until next milestone

First Posted

Study publicly available on registry

August 28, 2019

Completed
2 years until next milestone

Study Start

First participant enrolled

September 1, 2021

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2026

Expected
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

January 27, 2021

Status Verified

January 1, 2021

Enrollment Period

4.9 years

First QC Date

May 24, 2019

Last Update Submit

January 26, 2021

Conditions

Keywords

ACLBiofeedbackInjury PreventionVirtual Reality

Outcome Measures

Primary Outcomes (1)

  • Change in knee flexion measured using motion analysis system

    measurement of knee flexion pre and post intervention to determine any change

    6 years

Secondary Outcomes (1)

  • Change in knee abduction moment measured using motion analysis system

    6 years

Study Arms (2)

MaNMT Biofeedback

EXPERIMENTAL

A group that will receive a neuromuscular training intervention that incorporates biofeedback training

Other: MaNMT Biofeedback

Sham

SHAM COMPARATOR

a group that will receive the same neuromuscular training intervention with sham feedback training.

Other: MaNMT Biofeedback

Interventions

neuromuscular training intervention that incorporates biofeedback training

MaNMT BiofeedbackSham

Eligibility Criteria

Age12 Years - 18 Years
Sexmale(Gender-based eligibility)
Gender Eligibility Detailsstudy is limited to male subjects
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee InjuriesLeg InjuriesWounds and Injuries

Study Officials

  • Gregory D Myer, PhD

    Cincinnati Childrens Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Kim D Barber Foss, MS

CONTACT

Staci Thomas, MS

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Masking Details
Randomization and double blind
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 24, 2019

First Posted

August 28, 2019

Study Start

September 1, 2021

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

January 27, 2021

Record last verified: 2021-01