Optimizing the Approach of Mobile Application Use to Improve Medication Adherence in Patients With Hypertension

NCT04066010 | Completed

• 1 other identifier: H1605145
• Study Type: interventional
• Target: 55
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study was to determine the effectiveness of using a custom-designed mobile application to improve blood pressure (BP) and promote adherence to antihypertensive medication regimens. This was a prospective, multicenter, randomized controlled trial. Patients were randomized to an intervention or control group for three months. Antihypertensive medication refill history was assessed three months before, during and three months after the study period. Continuous outcome measures investigated were systolic/diastolic BP and medication refill history, using the cumulative medication gap (CMG) score.

Conditions

Medication Adherence; Hypertension

Outcome Measures

Primary Outcomes (2)

• Medication adherence

  This was assessed based on cumulative medication gap (CMG)

  6 months

• Blood pressure

  This was assessed by measuring the change of systolic and diastolic blood pressure

  6 months

Study Arms (2)

Control

NO INTERVENTION

Intervention

OTHER

Mobile application intervention

Other: Mobile application (BP-n-Me)

Interventions

Mobile application (BP-n-Me) OTHER

The mobile app consisted of a series of features including (1) calendar reminders of when to take medications and the patient's antihypertensive medication regimen (2) a "Call your Pharmacist" button specific to patient's pharmacy, (3) a BP log in which the patient could enter blood pressure values that were automatically compared to goal values, (4) counseling points for lifestyle and adherence factors individually tailored to each patient and (5) lifestyle and medication adherence surveys.

Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age
• Diagnosed with hypertension as evidenced by diagnosis codes or chart documentation
• Prescribed at least one antihypertensive for a minimum of three months prior to enrollment
• Have access to an Android mobile device with data capabilities
• Consent to using the application on their device

You may not qualify if:

• Do not read or speak English
• Unable to read and sign the informed consent or Health Insurance Privacy and Accountability Act (HIPAA) waiver
• Too ill or cognitively impaired to participate

Sponsors & Collaborators

• Mercer University: lead
• Emory Healthcare: collaborator
• Grady Health System: collaborator
• Atlanta Medical Center: collaborator

Related Publications (1)

• Palmer MJ, Machiyama K, Woodd S, Gubijev A, Barnard S, Russell S, Perel P, Free C. Mobile phone-based interventions for improving adherence to medication prescribed for the primary prevention of cardiovascular disease in adults. Cochrane Database Syst Rev. 2021 Mar 26;3(3):CD012675. doi: 10.1002/14651858.CD012675.pub3.

  PMID: 33769555 DERIVED

MeSH Terms

Conditions

Medication Adherence; Hypertension

Condition Hierarchy (Ancestors)

Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2019
• First Posted: August 22, 2019
• Study Start: October 1, 2016
• Primary Completion: May 1, 2018
• Study Completion: November 1, 2018
• Last Updated: August 30, 2019

Record last verified: 2019-08

Data Sharing

• IPD Sharing: Will not share