Exercise Training as Medicine for Substance Use Disorder Patients

NCT04065334 | Completed

• 1 other identifier: 2019/502
• Study Type: interventional
• Target: 171
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients. The hypothesis is that the increase in endurance (measured as maximal oxygen uptake) and strength (measured as maximal strength) will be similar in both the high dose and low dose training groups after 24 training sessions over eight weeks. The rationale for this assumption is based on the patient groups poor physical capacity, supporting that a lesser physical workload is needed to achieve a substantial increase in physical capacity. The practical implication could be higher training attendance, because it is likely easier to motivate the patient group when they only have to perform half the workload. It is paramount for this patient group to increase their physical capacity and consequently augment their physical health status since they are in a high-risk group for developing life-threatening lifestyle related diseases.

Conditions

Substance Use Disorders

Keywords

Resistance training; Endurance training

Outcome Measures

Primary Outcomes (2)

• change in oxygen uptake

  cardiopulmonary exercise test (CPET) objective gas measurements

  baseline to 8 weeks

• change in leg muscular strength

  One repetition maximum strength test half squat

  baseline to 8 weeks

Study Arms (2)

low dose training

EXPERIMENTAL

Behavioral: low dose training

high dose training

ACTIVE COMPARATOR

Behavioral: High dose training

Interventions

High dose training BEHAVIORAL

4 x 4 minutes of high intensity workload on treadmill and 4 repetitions x 4 sets of high intensity workload in hack squat

high dose training

low dose training BEHAVIORAL

1 x 4 minutes of high intensity workload on treadmill and 2 repetitions x 4 sets of high intensity workload in hack squat

low dose training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being an inpatient at the clinic
• Free of known cardiovascular disease, pulmonary disease and cancer

You may not qualify if:

• Not able to perform a maximal treadmill test
• Not able to perform a maximal strength test in hack squat

Sponsors & Collaborators

• St. Olavs Hospital: lead
• Norwegian University of Science and Technology: collaborator

Study Sites (1)

Klinikk for rus- og avhengighetsmedisin, St Olavs Hospital

Trondheim, Norway

Location

Related Publications (1)

• Loe H, Mosti MP, Wisloff U, Haberstroh C, Flemmen G. Cardiopulmonary and muscular effects of different doses of high-intensity physical training in substance use disorder patients: study protocol for a block allocated controlled endurance and strength training trial in an inpatient setting. BMJ Open. 2022 Sep 27;12(9):e061014. doi: 10.1136/bmjopen-2022-061014.

  PMID: 36167363 DERIVED

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders

Study Officials

• Kristin Smedsrud

  St. Olavs Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2019
• First Posted: August 22, 2019
• Study Start: February 1, 2020
• Primary Completion: December 11, 2023
• Study Completion: December 11, 2023
• Last Updated: June 8, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)