Diagnosis-related Outcomes in NeurocriTical Care: Prognostic Estimate by Health-care Providers Versus Risk Scores in Intracerebral and Subarachnoid Hemorrhage
DON´T-PERISH
1 other identifier
observational
1,085
1 country
10
Brief Summary
The aim of the observational multicenter trial encompasses the comparison of estimation of the long-term prognosis (functional and cognitive outcomes, quality of life) after intracerebral and subarachnoid hemorrhages assessed by clinical scores, treating physicians and nurses. The scores and the assessment of the treating physicians and nurses are recorded on admission, at 7 and 14 days after symptom onset.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2019
Longer than P75 for all trials
10 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 30, 2019
CompletedFirst Posted
Study publicly available on registry
August 21, 2019
CompletedStudy Start
First participant enrolled
December 12, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2025
CompletedFebruary 5, 2026
March 1, 2025
5.2 years
April 30, 2019
February 3, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Modified Rankin Scale dichotomized 0-2 versus 3-6 at 6 months
Modified Rankin Scale dichotomized 0-2 (good functional outcome) versus 3-6 (poor functional outcome)
6 months
Secondary Outcomes (6)
Modified Rankin Scale dichotomized 0-2 versus 3-6 at 3 months
3 months
Modified Rankin Scale dichotomized 0-3 versus 4-6 at 6 months
6 months
Modified Rankin Scale dichotomized 0-3 versus 4-6 at 3 months
3 months
Quality of life measured by Short Form Health Survey Short Form (SF)-36
3 and 6 months
Quality of life measured by Sickness Impact Profile
3 and 6 months
- +1 more secondary outcomes
Interventions
assessment at different time points
Eligibility Criteria
All patients admitted with acute spontaneous intracerebral and nontraumatic subarachnoid hemorrhage to a center with neurocritical care expertise
You may qualify if:
- Spontaneous intracerebral hemorrhage or nontraumatic subarachnoid hemorrhage
- Treatment in Centers with neurocritical care expertise
You may not qualify if:
- Language other than German and English
- Restriction of diagnostic and therapeutic measures during acute hospitalization according to advanced directives
- Admission \> 48 hours after symptom onset
- Hemorrhage due to trauma
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Leipziglead
- German Society of Neurocritical Carecollaborator
Study Sites (10)
Charité University Hospital
Berlin, Germany
University Hospital of Duesseldorf
Düsseldorf, Germany
University of Frankfurt
Frankfurt, Germany
Wolf-Dirk Niesen
Freiburg im Breisgau, Germany
University of Leipzig
Leipzig, 04103, Germany
University of Mainz
Mainz, 55131, Germany
Minden Hospital
Minden, Germany
LMU University of Munich
Munich, Germany
Osnabrueck Hospital
Osnabrück, Germany
University Hospital of Regensburg
Regensburg, Germany
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Katja E Wartenberg, MD
University of Leipzig
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 30, 2019
First Posted
August 21, 2019
Study Start
December 12, 2019
Primary Completion
February 28, 2025
Study Completion
February 28, 2025
Last Updated
February 5, 2026
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share