NCT04060186

Brief Summary

In this prospective, randomized, multicenter trial shall patients with chronic subdural hematoma (cSDH) recruited, who were surgically treated. Initially, we would divide the patients randomized into two groups: Patients with supervised blow-maneuver and without. After surgical treatment of cSDH with insertion of a subdural drain, one group would perform a supervised blow maneuver ("Valsalva maneuver") every hour for five minutes from 10:00 to 20:00. In the other group, the standard care would be performed. The subdural drain would be explanted 2days after operation and a postoperative CT scan would routinely be performed. After hospital discharge, the patient would be rechecked in an ambulant setting and would receive CT scan as clinical standard. Recurrence of hematoma is defined as recurrent hematoma which should be reoperated. After 3 and 6 months we would evaluate the outcome of patients.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 6, 2019

Completed
13 days until next milestone

First Posted

Study publicly available on registry

August 19, 2019

Completed
5 months until next milestone

Study Start

First participant enrolled

January 1, 2020

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 30, 2021

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2022

Completed
Last Updated

December 20, 2019

Status Verified

December 1, 2019

Enrollment Period

1.7 years

First QC Date

August 6, 2019

Last Update Submit

December 18, 2019

Conditions

Keywords

Recurrence rate of cSDHOutcome

Outcome Measures

Primary Outcomes (1)

  • Recurrence Rate

    Reoperation of chronic subdural hematoma

    3 Months

Secondary Outcomes (1)

  • Neurological Functional Outcome

    6 Months

Study Arms (2)

Balloninflation Group

ACTIVE COMPARATOR

Patient who will perform a balloninflation after operation

Procedure: Balloninflation

Conservative Group

SHAM COMPARATOR

Patient without performing a balloninflation

Procedure: Balloninflation

Interventions

Patient will inflate into a ballon made by a handglove 2-3times/h from 8:00-20:00 after evacuation of chronic subdural hematoma.

Balloninflation GroupConservative Group

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age over 18 years
  • surgically treated cSDH
  • patients with an operatively implanted subdural drainage

You may not qualify if:

  • age under 18 years
  • Admission in critical clinical state, e.g. already to light unresponsive pupils for about 2 hours
  • conservative treatment of cSDH
  • patients without an operatively implanted subdural drainage
  • patient cannot be consented
  • participation in other clinical trials

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital

Niederrad, Hesse, 60528, Germany

RECRUITING

MeSH Terms

Conditions

Hematoma, Subdural, Chronic

Condition Hierarchy (Ancestors)

Hematoma, SubduralIntracranial Hemorrhage, TraumaticIntracranial HemorrhagesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesCraniocerebral TraumaTrauma, Nervous SystemVascular DiseasesCardiovascular DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsHematomaHemorrhageWounds and Injuries

Central Study Contacts

Sae-Yeon Won, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Study Nurse

Study Record Dates

First Submitted

August 6, 2019

First Posted

August 19, 2019

Study Start

January 1, 2020

Primary Completion

August 30, 2021

Study Completion

February 28, 2022

Last Updated

December 20, 2019

Record last verified: 2019-12

Locations