Outcome of Patients With Thoraco-abdominal Injury and Stress-induced Hyperglycemia or Diabetic Hyperglycemia

NCT04058015 | Completed

• 1 other identifier: 201900726B0
• Study Type: observational
• Target: 802
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury

Conditions

Abdominal Injury; Thoracic Injury; Hyperglycemia; Hyperglycemia Stress

Keywords

admission hyperglycemia; stress-induced hyperglycemia; diabetic hyperglycemia; diabetes mellitus; thoracoabdominal trauma; mortality

Outcome Measures

Primary Outcomes (1)

• in-hospital mortality

  The primary outcome of the study was in-hospital mortality.

  up to 6 months

Study Arms (1)

adult patients with thoracoabdominal injuries

adult patients with moderate to severe thoracoabdominal injuries

Other: Stress-induced hyperglycemia; Other: Diabetic hyperglycemia; Other: Diabetic normoglycemia; Other: Non-diabetic normoglycemia

Interventions

Stress-induced hyperglycemia OTHER

Stress-induced hyperglycemia (SIH)was defined as a serum glucose ≥ 200 mg/dL in the patients without Diabetes mellitus.

adult patients with thoracoabdominal injuries

Diabetic hyperglycemia OTHER

Diabetic hyperglycemia (DH) which indicated a serum glucose ≥ 200 mg/dL in patients with Diabetes mellitus.

adult patients with thoracoabdominal injuries

Diabetic normoglycemia OTHER

Diabetic normoglycemia (DN), which was defined when there was a serum glucose \< 200 mg/dL in the patients with Diabetes mellitus.

adult patients with thoracoabdominal injuries

Non-diabetic normoglycemia OTHER

Non-diabetic normoglycemia (NDN) indicating a serum glucose \< 200 mg/dL in patients who were absent of Diabetes mellitus.

adult patients with thoracoabdominal injuries

Eligibility Criteria

• Age: 20 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This retrospective study reviewed data from trauma patients registered between January 1, 2009 and December 31, 2018. The inclusion criteria were age ≥20 years Adult patients with moderate to severe thoracoabdominal injuries (n = 802) were grouped into four exclusive subgroups: (1) SIH, which was defined as a serum glucose ≥ 200 mg/dL in the patients without DM (n = 52); (2) DH, which indicated a serum glucose ≥ 200 mg/dL in patients with DM (n = 79); (3), DN, which was defined when there was a serum glucose \< 200 mg/dL in the patients with DM (n = 50); and (4) NDN, indicating a serum glucose \< 200 mg/dL in patients who were absent of DM (n = 621)

You may qualify if:

• adult patients with moderate to severe thoracoabdominal injuries

You may not qualify if:

• patients with a thoracic and abdominal abbreviated injury scale (AIS) \< 3
• patients who had polytrauma which was defined as there was additional AIS scores ≥ 3 points in other regions of the body
• patients less than 20 years old
• patients who had sustained a burn injury

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 83301, Taiwan

Location

MeSH Terms

Conditions

Abdominal Injuries; Thoracic Injuries; Hyperglycemia; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Wounds and Injuries; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• TSANG-TANG Hsieh

  Chang Gung Memorial Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 13, 2019
• First Posted: August 15, 2019
• Study Start: June 3, 2019
• Primary Completion: July 1, 2019
• Study Completion: August 9, 2019
• Last Updated: August 15, 2019

Record last verified: 2019-06

Locations

TW (1)