NCT04054739

Brief Summary

Effects of robot-assisted gait training on cortical activity and gait function in hemiparetic stroke

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at P25-P50 for not_applicable stroke

Timeline
Completed

Started Sep 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2018

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

August 12, 2019

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 13, 2019

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2019

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2019

Completed
Last Updated

February 11, 2020

Status Verified

February 1, 2020

Enrollment Period

1.2 years

First QC Date

August 12, 2019

Last Update Submit

February 9, 2020

Conditions

Keywords

robot-assisted gait trainingcortical activitygait kinematicsstroke

Outcome Measures

Primary Outcomes (2)

  • oxygenated hemoglobin levels

    cortical activity of primary sensorimotor cortex, premotor cortex, supplementary motor areas, pre-supplementary motor areas, prefrontal cortex during gait

    4 weeks from baseline

  • Range of motion of ankle, knee, and hip joint

    ankle, knee, and hip joint motion of sagittal plane during gait

    4 weeks from baseline

Secondary Outcomes (20)

  • oxygenated hemoglobin levels

    baseline, 2 weeks after baseline, 4 weeks after baseline, 8 weeks after baseline

  • Range of motion of ankle, knee, and hip joint

    baseline, 2 weeks after baseline, 4 weeks after baseline, 8 weeks after baseline

  • Berg Balance Scale

    baseline, 2 weeks after baseline, 4 weeks after baseline, 8 weeks after baseline

  • Fugl-Meyer Assessment

    baseline, 2 weeks after baseline, 4 weeks after baseline, 8 weeks after baseline

  • 10m walk test

    baseline, 2 weeks after baseline, 4 weeks after baseline, 8 weeks after baseline

  • +15 more secondary outcomes

Study Arms (2)

Robot-assisted gait training

EXPERIMENTAL

experimental group that applied the end-effector robot-assisted gait training

Device: Robot-assisted gait training

Treadmill gait training

ACTIVE COMPARATOR

control group that applied the treadmill gait training

Device: Treadmill gait training

Interventions

intervention with robot-assisted gait training

Robot-assisted gait training

intervention with treadmill gait training

Treadmill gait training

Eligibility Criteria

Age19 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Hemiplegic patients secondary to first cerebrovascular accidents
  • Functional ambulation category score 3
  • months ≤ Onset ≤ 12 months
  • Korean Mini-Mental State Examination score \> 24

You may not qualify if:

  • History of surgery of affected lower limb
  • Fracture of affected lower limb

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Rehabilitation Center

Seoul, 142884, South Korea

Location

Related Publications (1)

  • Kim H, Park G, Shin JH, You JH. Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial. Sci Rep. 2020 Jul 27;10(1):12461. doi: 10.1038/s41598-020-69367-3.

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Joon-Ho Shin, MS

    National Rehabilitation Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Team manager

Study Record Dates

First Submitted

August 12, 2019

First Posted

August 13, 2019

Study Start

September 1, 2018

Primary Completion

November 30, 2019

Study Completion

December 31, 2019

Last Updated

February 11, 2020

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will not share

Locations