CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients

NCT04049565 | Completed

• 1 other identifier: PCTCRP
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Sepsis is a life threatening organ dysfunction caused by infection. Severe sepsis is expected to rise due to resistance to antibiotics. Inappropriate use of antibiotics in the ICU leads to adverse drug reaction and bacterial resistance. Using biomarkers for infection as PCT and CRP are useful in diagnosing infection and duration of therapy. CRP based protocol will be compared to PCT based protocol for reducing the length of stay and reduction of antibiotic use in critically ill patients.

Conditions

Sepsis; Morality

Outcome Measures

Primary Outcomes (1)

• compare between CRP and procalcitonin in guiding antibiotic therapy in sepsis and septic shock

  measurement of the accuracy and validity of CRP and PCT as biomarkers of sepsis

  one year

Study Arms (2)

Procalcitonin

septic patients who will receive Procalcitonin

Diagnostic Test: Procalcitonin biomarker and CRP biomarker

C-Reactive Protein

septic patients who will receive C-Reactive ptotein

Diagnostic Test: Procalcitonin biomarker and CRP biomarker

Interventions

Procalcitonin biomarker and CRP biomarker DIAGNOSTIC_TEST

collecting blood samples to measure serum CRP and Procalcitonin

C-Reactive Protein; Procalcitonin

Eligibility Criteria

• Age: 18 Years - 69 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with sepsis or septic shock

You may qualify if:

• Age \>18 and less than 70

You may not qualify if:

• \- Elderly (defined as older than 70).
• Pregnancy and lactation
• Immunocompromised patients or who had high doses of corticosteroids
• Patients with chronic organ failure
• Infections that required long-term treatment, regardless of the etiologic agent (e.g., bacterial endocarditis).

Sponsors & Collaborators

• Beni-Suef University: lead

Study Sites (1)

Cairo University Hospital

Cairo, 11865, Egypt

Location

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Abdelrahman Dr ElNaggar, Prof

  study official is dead

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Pharmacist / Walid Ahmed Ali Abdeltawab

Study Record Dates

• First Submitted: August 6, 2019
• First Posted: August 8, 2019
• Study Start: October 1, 2018
• Primary Completion: February 1, 2019
• Study Completion: March 15, 2019
• Last Updated: February 5, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)