A 7-year Prospective Study of Idiopathic REM Sleep Behavior Disorder Cohort in Chinese Population: Determining the Optimal Characteristics of Biomarkers to Predict Neurodegenerative Diseases
Sponsor study identifier
observational
182
1 country
1
Study Start
May 15, 2019
Actual (reported)Primary Completion
March 31, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 1, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in patients with idiopathic REM Sleep Behavior Disorder (iRBD) and healthy controls.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 1, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 22, 2019
Actual (reported)May 15, 2019
Actual (reported)August 7, 2019
Actual (reported)March 31, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 1, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The overall conversion rate of iRBD to neurodegenerative diseases
The overall conversion rate of iRBD to neurodegenerative diseases. The diagnoses of neurodegenerative diseases will be ascertained by neurologists according to the standard diagnostic criteria.
Changes from baseline to 7 year follow up
Changes of the likelihood ratio of probability of prodromal Parkinson's disease in each individual
Baseline and 7 year
Conversion rate of iRBD to neurodegenerative diseases in patients with high and low likelihood ratio of probability of prodromal Parkinson's disease in each individual
Changes from baseline to 7 year follow up
Subjects with the diagnosis of idiopathic REM sleep behavior disorder
Healthy controls without the diagnosis of idiopathic REM sleep behavior disorder
The participants in this proposed study will be recruited from our on-going cohort of RBD and control
Department of psychiatry, Faculty of Medicine, The Chinese University of Hong Kong
Hong Kong, Hong Kong
Thyroid Function Tests(TFT), Vitamin B12, Folate, Complete Blood Count(CBC), Fasting Glucose, Liver Function Tests(LFT), Renal Function Tests(RFT), C-reactive protein(CRP), Fasting lipid, Iron profile, Phosphate, Calcium, Neurosteroid, Genetic analysis
Jihui Zhang, PhD
Chinese University of Hong Kong
Yun Kwok Wing, MBChB
Chinese University of Hong Kong
Yaping Liu, PhD
Chinese University of Hong Kong
Siu Ping Lam, MBChB
Chinese University of Hong Kong
First Submitted
March 22, 2019
First Posted
August 7, 2019
Study Start
May 15, 2019
Actual (reported)Primary Completion
March 31, 2022
Estimated (date passed)Establish a National Registry of REM Sleep Behavior Disorder
Contact the study team to confirm eligibility.
Shirley Xin Li, PhD
The University of Hong Kong
Vincent Chung Tong Mok, MBChB
Chinese University of Hong Kong
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 1, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
August 6, 2021
Record last verified: 2021-08
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