Exploration of the Mechanisms of Vulnerability of Anorexia Nervosa at an Early Age : Study of the Cognitive Treatment of Food Stimuli and Body Image

NCT04037215 | Unknown

• 1 other identifier: K170607J
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

In order to explore the cognitive treatment of patients with early onset anorexia nervosa (AM) in front of images of silhouettes and food, we will use the eye-tracking method. While we hypothesize a judgment disorder in these patients, the exploration of implicit cognitive treatment without desirability bias is essential. Eye-tracking is a method of recording the eye path that provides qualitative and quantitative information on the visual exploration of subjects. The visual pathway depends on how the subject's attention is directed to a given stimulus, but also on certain cognitive traits (e.g., excessive attention to details) or symptoms (e.g., avoidance of caloric food images or attraction to thin images). It is therefore a non-invasive exploration tool, which provides information on how patients look at food images and silhouettes. This project will describe the cognitive treatment of dietary stimuli and body image in young patients with early onset AM. It could identify a biomarker of AM in the pediatric population and improve the diagnosis of the disease. A better diagnosis of AM in patients under 15 years of age is essential and will improve medical care and develop personalized medicine.

Conditions

Anorexia Nervosa

Keywords

eye tracking; cognitive processing

Outcome Measures

Primary Outcomes (1)

• cognitive processing

  cognitive processing in front of 20 images of food and silhouettes of variable weight

  one day

Secondary Outcomes (3)

• fixing a region of interest

  one day

• body mass index

  one day

• total score on the Morgan and Russell scale

  one day

Study Arms (1)

COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE

OTHER

In order to explore the cognitive treatment of patients with early onset anorexia nervosa in front of images of silhouettes and food, it is currently used in the child psychiatry department of the Robert Debré Hospital, the eye-tracking method. Eye tracking is a non-invasive and painless method of recording the path of vision on images presented on a computer screen. In order to understand the specificities of the eye path in sick patients, we will compare the data with those of controls without eating disorders.

Other: STUDY OF THE COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE

Interventions

STUDY OF THE COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE OTHER

Describe the cognitive treatment of patients with early onset anorexia nervosa in response to specific stimuli of the disorder (eating and body images), compared to age- and sex-matched control subjects: * children controls not achieved with normal BMI; * children with unbalanced insulin-dependent type 1 diabetes, therefore subject to a strict diet that requires good nutritional knowledge and no weight judgment disorders.

COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE

Eligibility Criteria

• Age: 8 Years - 14 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Patients with anorexia nervosa.
• Age 8 to 14 years,
• Early AM diagnosis (AM DSM-5 criteria, and presence of primary amenorrhea at diagnosis for girls),
• Follow-up in the Child Psychiatry Department of the Robert Debré Hospital,
• Affiliation to a social security system,
• Authorization of the holder(s) of parental authority and acceptance of the child to participate in this research.
• Witnesses from the general population:
• Age 8 to 14 years,
• Normal Height-weight development defined by: Weight, Height, BMI between 10° and 90° percentile for age and sex, without changing the growth curve.
• Authorization of the holder(s) of parental authority and acceptance of the child to participate in this research
• Witnesses with type 1 diabetes:
• Age 8 to 14 years,
• Type 1 diabetes for more than a year,
• Follow-up in the endocrinology department of the Robert Debré Hospital,
• Normal height-weight development defined by: Weight, Height, BMI between 10° and 90° percentile for age and sex, without changing the growth curve.

You may not qualify if:

• Patients with AM.
• Other Axis I disorder (Kiddie SAS)
• Existence of a severe neurosensory disorder
• Existence of a neurological disorder
• other eating disorders(DSM-5)
• Diabetes type 1
• Witnesses :
• Any Axis I psychiatric disorder
• Existence of an intellectual deficit
• Existence of a severe neurosensory disorder
• Existence of a neurological disorder
• Long-term drug treatment (other than insulin for controls with type 1 diabetes)
• Type 1 diabetes (for controls in the general population)

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Hôpital Robert Debré

Paris, 75019, France

RECRUITING

MeSH Terms

Conditions

Anorexia Nervosa

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders

Study Officials

• Clarke Julia, PhD

  APHP

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Clarke Julia, PhD

CONTACT

01 40 03 22 96; julia.clarke@aphp.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All assessments in patients with AM are performed as part of routine care and do not require additional monitoring modalities added by research. For controls, phenotypic exploration will require a consultation with clinical examination including the search for psychiatric comorbidities and the completion of standardized questionnaires, exploration of the neuropsychological profile (with eye tracking, overall cognitive exploration, executive functions, social cognition and self-esteem). Test results will not be returned except for screening requiring specific management. The information will then be returned to the child's parents by the investigating doctor, who will be responsible for organizing specific care whenever it is necessary.

Study Record Dates

• First Submitted: July 26, 2019
• First Posted: July 30, 2019
• Study Start: November 19, 2019
• Primary Completion: December 19, 2022
• Study Completion: December 19, 2022
• Last Updated: October 18, 2021

Record last verified: 2021-10

Locations

FR (1)