Genomic BRCA and Extensive ovArian Cancer Testing
GREAT
Cohort Study to Evaluate the Clinical Features of Patients With Epithelial Ovarian Cancer Depending on Tumoral Mutation of BRCA or Beyond BRCA Genomic Molecular Abnormalities
3 other identifiers
observational
1,500
1 country
137
Brief Summary
This is a prospective observational French multicenter cohort in patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014). The objective is to constitute a clinico-biological database that allows to correlate clinical and progressive features of ovarian cancer patients based on tumor genomics and molecular detected abnormalities.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2019
Typical duration for all trials
137 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 18, 2019
CompletedFirst Posted
Study publicly available on registry
July 22, 2019
CompletedStudy Start
First participant enrolled
December 6, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 7, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
November 7, 2022
CompletedFebruary 17, 2026
February 1, 2026
2.9 years
July 18, 2019
February 13, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Correlation between Progression Free Survival (PFS) and the detected tumor genetic abnormalities
From baseline until the date of progression or death, which ever occurs earlier, assessed up to 10 years
Secondary Outcomes (6)
Correlation between age and the detected tumor genetic abnormalities
Baseline
Correlation between histology status and the detected tumor genetic abnormalities
Baseline
Correlation between FIGO stage and the detected tumor genetic abnormalities
Baseline
Correlation between surgery resection status and the detected tumor genetic abnormalities
Up to 10 years
Correlation between treatment response and the detected tumor genetic abnormalities
Up to 10 years
- +1 more secondary outcomes
Other Outcomes (3)
Percentage of patients with both germinal and tumoral BRCA tests
Up to 10 years
Percentage of patients with a first germinal BRCA test, a first tumoral BRCA test, or simultaneous germinal and tumoral tests
Up to 10 years
Percentage of patients with and exploitable tumoral block for exploratory transversal researches
Up to 10 years
Eligibility Criteria
Patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014)
You may qualify if:
- Patient older than 18 years.
- Patient with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014)
- Patient in first line therapy
- Available tumor sample fixed in formalin and included in paraffin (FFPE):
- in pre-chemotherapy, insofar as possible
- having a sufficient tumor surface, with a final cellularity of at least 20%
- Identification of a molecular genetics' cancer platform participant in GREAT and an onco-geneticists team working with the investigator team
- Patient consenting her data to be collected and submitted through an automated processing
- Patient beneficiary from the French social security
You may not qualify if:
- Patient with a mucinous ovarian carcinoma
- Patient pregnant or breastfeeding
- Patient under legal protection (guardianship or court order) or unable to consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecacollaborator
- ARCAGY/ GINECO GROUPlead
Study Sites (137)
Centre de Radiothérapie et d'Oncologie de Moyenne Garonne (CROMG)
Agen, 47000, France
Hôpital Privé d'Aix en Provence
Aix-en-Provence, 13080, France
Centre Hospitalier Général d'Aix-en-Provence
Aix-en-Provence, France
CHU Amiens
Amiens, France
Clinique Victor PAUCHET
Amiens, France
Institut de Cancérologie de l'Ouest - ICO
Angers, France
Hôpital Privé d'Antony - Ramsay Santé
Antony, 92160, France
CH Arras
Arras, France
CH Auxerre
Auxerre, France
Institut Sainte Catherine
Avignon, France
Clinique Belharra
Bayonne, 64100, France
CH Côte Basque
Bayonne, France
Centre Hospitalier de Beauvais
Beauvais, 60021, France
CHRU Jean Minjoz
Besançon, France
Reims Icone
Bezannes, 51100, France
CH de Blois
Blois, France
Hôpital Avicenne
Bobigny, 93009, France
CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, France
Clinique Tivoli
Bordeaux, France
Institut Bergonié
Bordeaux, France
Polyclinique Bordeaux Nord
Bordeaux, France
Centre Hospitalier Fleyriat - BOURG-EN-BRESSE
Bourg-en-Bresse, France
CHU Brest
Brest, France
Hôpital Femme Mère Enfant
Bron, 89500, France
Centre François Baclesse
Caen, France
Centre Maurice Tubiana
Caen, France
CH de Cahors
Cahors, France
CH Carcassonne
Carcassonne, France
Hôpital Général de Castres
Castres, France
Medipole de Savoie
Challes-les-Eaux, France
CH Chalon sur Saone
Chalon-sur-Saône, France
CH Metropole Savoie
Chambéry, France
Centre d'Oncologie et de Radiothérapie 37
Chambray-lès-Tours, France
Centre Hospitalier de Chateauroux
Châteauroux, 36000, France
CHPC - Hôpital Louis Pasteur
Cherbourg, France
CH Cholet
Cholet, France
Hôpital Antoine Béclère
Clamart, France
Centre Jean Perrin
Clermont-Ferrand, France
CH Alpes Léman
Contamine-sur-Arve, France
Centre Hospitalier Sud Francilien (Site Gilles de Corbeil)
Corbeil-Essonnes, 91106, France
Clinique des Cèdres
Cornebarrieu, 31700, France
Clinique de Flandre
Coudekerque-Branche, France
Groupe Hospitalier public du Sud de l'Oise (GHPSO)
Creil, France
CHI Creteil
Créteil, France
Centre Georges François Leclerc
Dijon, France
CHU Dijon
Dijon, France
Institut de Cancérologie de Bourgogne - GRReCC
Dijon, France
Clinique du Mousseau (CMCO) - Ramsay Santé
Évry, 91000, France
Centre Hospitalier Intercommunal de Fréjus Saint Raphael
Fréjus, 83600, France
GH Mutualiste de Grenoble
Grenoble, France
Hôpital Privé Drôme Ardèche - Clinique Pasteur
Guilherand-Granges, 07500, France
Centre Hospitalier Marne-la-Vallée
Jossigny, France
Centre Hospitalier Départemental de Vendée
La Roche-sur-Yon, 85925, France
CHU Grenoble Alpes - Site Nord (La Tronche)
La Tronche, France
Hôpital André Mignot
Le Chesnay, France
Les Hôpitaux de Chartres
Le Coudray, France
Hôpital Privé de l'Estuaire
Le Havre, 76600, France
CHU Bicêtre
Le Kremlin-Bicêtre, France
Centre Hospitalier du Mans
Le Mans, France
CH de Lens
Lens, France
Institut Hospitalier Franco-Britannique
Levallois-Perret, France
Polyclinique de Limoges - Clinique Chenieux
Limoges, 87039, France
CHU de Limoges - Hôpital Dupuytren
Limoges, 87042, France
Groupe Hospitalier Bretagne Sud - Hôpital du Scorff
Lorient, France
HCL - Hôpital de la Croix Rousse
Lyon, 60004, France
Clinique de l'infirmerie Protestante
Lyon, 69300, France
Centre Léon Bérard
Lyon, France
Clinique de la Sauvegarde
Lyon, France
Hôpital Privé Jean Mermoz
Lyon, France
APHM - Hôpital de la Timone
Marseille, France
Hôpital Nord
Marseille, France
Institut Paoli Calmettes
Marseille, France
Centre Hospitalier Layné
Mont-de-Marsan, 40024, France
Hôpital Nord Franche Comté
Montbéliard, France
CH de Montelimar
Montélimar, France
Centre de Cancérologe du Grand Montpellier
Montpellier, France
CHRU de Montpellier - Hôpital Saint-Eloi
Montpellier, France
ICM - Val d'Aurelle
Montpellier, France
Centre Azuréen de Cancérologie
Mougins, 06250, France
Oracle - Centre d'Oncologie de Gentilly
Nancy, France
Hôpital Privé du Confluent
Nantes, France
Clinique Hartmann
Neuilly-sur-Seine, France
Centre Antoine Lacassagne
Nice, 06000, France
Institut de Cancérologie du Gard - ONCOGARD
Nîmes, 30029, France
Institut de Cancérologie du Gard
Nîmes, France
CHR Orléans
Orléans, France
Hôpital de la Pitié Salpétrière
Paris, 75000, France
GH Saint Joseph
Paris, France
Groupe Hospitalier Diaconesses - Croix Saint-Simon
Paris, France
HEGP
Paris, France
Hôpital Bichat
Paris, France
Hôpital Cochin
Paris, France
Hôpital Lariboisière
Paris, France
Institut Curie
Paris, France
Institut Mutualiste Montsouris
Paris, France
CH Pau
Pau, France
Centre Catalan d'Oncologie
Perpignan, France
CH Perpignan
Perpignan, France
Clinique Francheville
Périgueux, France
HCL - Centre Hospitalier Lyon Sud
Pierre-Bénite, 69006, France
Centre CARIO-HPCA
Plérin, France
Hôpital de la Milétrie
Poitiers, France
CH René Dubos
Pontoise, France
CH Annecy Genevois
Pringy, France
Clinique de la Croix du Sud
Quint-Fonsegrives, France
Centre Eugène Marquis
Rennes, France
Hôpitaux Drôme Nord - Centre Hospitalier Romans
Romans-sur-Isère, 26100, France
Centre Henri Becquerel
Rouen, 76000, France
Clinique Mathilde
Rouen, 76100, France
Centre Frédéric Joliot
Rouen, France
Centre Hospitalier Yves Le Foll
Saint-Brieuc, France
Institut Curie - Site Saint Cloud
Saint-Cloud, 92210, France
Hôpital Privé de La Loire Saint-Etienne
Saint-Etienne, 42100, France
Centre Hospitalier Privé Saint Grégoire
Saint-Grégoire, France
Institut de Cancérologie de l'Ouest - ICO
Saint-Herblain, France
HIA Begin
Saint-Mandé, France
Clinique Mutualiste de l'Estuaire
Saint-Nazaire, France
CHU Saint-Etienne - Pôle de Cancérologie
Saint-Priest-en-Jarez, France
Centre Médicale Sainte Feyre Alfred Leune
Sainte-Feyre, 23000, France
Clinique Charcot
Sainte-Foy-lès-Lyon, France
Institut de Cancérologie Paris Nord
Sarcelles, France
CH Sens
Sens, France
CH Broussais
St-Malo, France
ICANS - Institut de cancérologie Strasbourg Europe
Strasbourg, 67037, France
Hôpital Foch
Suresnes, France
CHR Metz-Thionville / Hôpital de Mercy
Thionville, 45001, France
Hôpitaux du Léman
Thonon-les-Bains, France
Hôpital d'Instruction des Armées Saint-Anne
Toulon, 83800, France
Clinique Pasteur - Groupe Oncorad Garonne
Toulouse, France
Clinique Pasteur - Oncosud
Toulouse, France
Institut Claudius Regaud
Toulouse, France
CHU Bretonneau
Tours, France
Centre Hospitalier de Troyes
Troyes, France
CH Jean Bernard
Valenciennes, France
Clinique des Dentellières
Valenciennes, France
Institut de Cancérologie de Lorraine (ICL) - Centre Alexis Vautrin
Vandœuvre-lès-Nancy, France
Gustave Roussy
Villejuif, France
Biospecimen
Tumor sample fixed in formalin and included in paraffin (FFPE)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Thibault De La Motte Rouge, MD.
Centre Eugène Marquis, Rennes
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 10 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 18, 2019
First Posted
July 22, 2019
Study Start
December 6, 2019
Primary Completion
November 7, 2022
Study Completion
November 7, 2022
Last Updated
February 17, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share