Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives
Comparison of the Severity and Prevalence of Coronary Atherosclerosis With Tissue Compliance (HLA Similarity ) in Patients Within First Degree Relatives
1 other identifier
observational
60
1 country
1
Brief Summary
This study research the similarity of coronary artery lesions according to HLA tissue compatibility in fisrt degree relatives of the patients who just admitted clinic as Acute coronary syndrome and underwent angiyography before .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Sep 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 28, 2019
CompletedFirst Posted
Study publicly available on registry
July 2, 2019
CompletedStudy Start
First participant enrolled
September 18, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 7, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2021
CompletedSeptember 21, 2020
September 1, 2020
3 months
May 28, 2019
September 18, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
relation between HLA subgroups and severity and prevelance of coronary artery lesions
the hla similarity of two sibling patient %80 and the military syntax score %97,7
20 MAY 2019 - 30 MAY 2019
Interventions
there is not any intervention procedure
Eligibility Criteria
* male or female with age between 18-70 * hospital admission due to acute coronary syndrome with first degree relative history who had coronary angiyography before
You may qualify if:
- male or female with age between 18-70
- hospital admission due to acute coronary syndrome with first degree relative history who had coronary angiyography before
You may not qualify if:
- first degree relative without any angiyography history before for patients who admitted as acute coronary syndrome
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zeki Çetinkaya
Kayseri, Melikgazi, 38200, Turkey (Türkiye)
Related Publications (1)
Xiong Y, Wang L, Mo P, Huang G, Li A, Chai R, Lin X, Zhong Y, Liu B, Ou W, Liu B, Liu SM. Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese. Hum Immunol. 2017 Sep;78(9):540-546. doi: 10.1016/j.humimm.2017.06.003. Epub 2017 Jun 15.
PMID: 28624488BACKGROUND
Biospecimen
blood sample
MeSH Terms
Conditions
Study Officials
- STUDY DIRECTOR
Zeki Çetinkaya
Doctor
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
May 28, 2019
First Posted
July 2, 2019
Study Start
September 18, 2020
Primary Completion
December 7, 2020
Study Completion
January 1, 2021
Last Updated
September 21, 2020
Record last verified: 2020-09