Trials Sponsors Conditions Drugs Pricing

Conditions

Epilepsy, Post-Traumatic

Keywords

neuroinflammationactivated microgliaTSPOTraumatic Brain InjuryTBIPositron emission tomography

Outcome Measures

Primary Outcomes (2)

Quantification of [18F]DPA-714 binding in the brain following moderate to severe traumatic brain injury
2 weeks
Quantification of [18F]DPA-714 binding in the brain following moderate to severe traumatic brain injury
2 months

Secondary Outcomes (3)

Frequency of early seizures, epileptiform discharges, and post-traumatic epilepsy
Admission - two years
Modified Rankin Scale
3 and 6 months
Quantify the association between contusion volume and adjacent cerebral edema with [18F]DPA-714 binding on PET scans
2 weeks

Study Arms (1)

Moderate to Severe Traumatic Brain Injury

EXPERIMENTAL

All patients will undergo a \[18F\]DPA-714 PET scan of the brain 2 weeks and 2 months following moderate to severe traumatic brain injury to quantify neuroinflammation.

Drug: [18F]DPA-714 Positron Emission Tomography Scan

Interventions

[18F]DPA-714 Positron Emission Tomography ScanDrug

All patients will undergo a \[18F\]DPA-714 PET scan of the brain 2 weeks and 2 months following moderate to severe traumatic brain injury to quantify neuroinflammation.

Moderate to Severe Traumatic Brain Injury

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Eligibility Criteria

Age18 Years - 100 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Acute Traumatic Brain Injury (TBI)
Age 18-100 are eligible

Sponsors & Collaborators

University of California, Davis
Otherlead

Study Sites (1)

University of California, Davis

Sacramento, California, 95817, United States

MeSH Terms

Conditions

Epilepsy, Post-TraumaticNeuroinflammatory DiseasesBrain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Brain InjuriesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesEpilepsyCraniocerebral TraumaTrauma, Nervous SystemWounds and InjuriesInflammationPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type: interventional
Phase: phase 1
Allocation: NA
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 24, 2019

First Posted

June 26, 2019

Study Start

February 1, 2020

Actual (reported)

Primary Completion

August 14, 2025

Actual (reported)

Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (3)

Study Arms (1)

Moderate to Severe Traumatic Brain Injury

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (3)

Study Arms (1)

Moderate to Severe Traumatic Brain Injury

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations