Trials Sponsors Conditions Drugs Pricing

Conditions

Ischemic Heart Disease Ventricular Tachycardia

Keywords

VentricularTachycardiaIschaemicMappingAblation

Outcome Measures

Primary Outcomes (1)

Combined ICD Therapies and Mortality
ICD therapy (ATP and shocks) for sustained ventricular tachycardia or ventricular fibrillation as documented by the patients device. Device interrogations occur 3 monthly. Combined with Mortality (all-cause) by 1 year.
12 months

Secondary Outcomes (7)

Achievement of the ablation procedure protocol end-point
Procedure
Total ICD therapy rate
12 months
Total VT Episodes
12 months
Appropriate ATP therapy rate
12 months
Appropriate ICD Shocks rate
12 months
+2 more secondary outcomes

Study Arms (1)

Ripple Mapping guided ischaemic VT ablation

OTHER

Patients referred for ablation of ischaemic VT undergo Ripple Mapping guided procedure.

Procedure: Ripple Mapping guided ischaemic VT ablation

Interventions

Ripple Mapping guided ischaemic VT ablationProcedure

Endocardial mapping of the ventricle performed with Ripple Mapping (CARTO3v6, Biosense Webster Inc). Ablation (SmarTouch Thermocool Catheter, Biosense Webster Inc) delivered to areas of abnormal "late" electrical activity within ventricular scar tissue.

Ripple Mapping guided ischaemic VT ablation

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 80 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Patients with coronary artery disease and ischaemic cardiomyopathy requiring ICD implantation for primary or secondary prevention.
Any episode of VT detected or treated appropriately (within monitor zone or therapy (ATP/shock) delivered) or by 12 lead ECG if the rate below the detection level of the device. An episode of VT will be defined as lasting more than 30 secs or a regular high rate episode meeting VT criterion for \>50% of the time before the first therapy is delivered (i.e. VT degenerating into VF is acceptable under these circumstances).

Sponsors & Collaborators

Papworth Hospital NHS Foundation Trust
Governmentcollaborator
Hospital de Santa Maria, Portugal
Othercollaborator
Newcastle-upon-Tyne Hospitals NHS Trust

Study Sites (1)

Hammersmith Hospital, Imperial College Healthcare NHS Trust

London, W12 0HS, United Kingdom

Related Publications (1)

Katritsis G, Kailey B, Jamil-Copley S, Luther V, Koa-Wing M, Cortez-Dias N, Carpinteiro L, de Sousa J, Martin R, Murray S, Das M, Whinnett Z, Lim PB, Peters NS, Ng FS, Chow AW, Linton NWF, Kanagaratnam P. RIPPLE-VT study: Multicenter prospective evaluation of ventricular tachycardia substrate ablation by targeting scar channels to eliminate latest scar potentials without direct ablation. Heart Rhythm. 2024 Dec;21(12):2481-2490. doi: 10.1016/j.hrthm.2024.05.046. Epub 2024 Jun 6.
PMID: 38848856DERIVED

MeSH Terms

Conditions

Tachycardia, VentricularMyocardial IschemiaTachycardiaIschemia

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesCardiac Conduction System DiseasePathologic ProcessesPathological Conditions, Signs and SymptomsVascular Diseases

Study Officials

Prapa Kanagaratnam
Imperial College Healthcare NHS Trust
PRINCIPAL INVESTIGATOR

Enrollment

50 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 24, 2019

First Posted

June 25, 2019

Study Start

April 18, 2019

Actual (reported)

Ripple Mapping Guided Ablation of Ischaemic Ventricular Tachycardia.

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Study Arms (1)

Ripple Mapping guided ischaemic VT ablation

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Study Arms (1)

Ripple Mapping guided ischaemic VT ablation

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations