Hand Grip Strength and Medical Research Council Scale as Predictors of Weaning Failure

NCT03991702 | Completed

• 1 other identifier: 49900015.0.0000.5327
• Study Type: observational
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

The handgrip strength (HGS) will be measured with a digital dynamometer. Three measurements will be taken, whose average of the three measurements will be collected. Muscle weakness will be diagnosed based on previously published ICU acquired weakness (ICU-AW) scores (for males \<11 kg and females \<7 kg). The overall motor function of the patient will be assessed using the Medical Research Council (MRC) scale. The maximum score of the scale is 60 points, adding the degree of muscle strength of all muscle groups tested. If the patient is unable to have one of the limbs tested, it is assumed that the limb would have the same force as the contralateral limb. A score of 48 points or less is indicative of muscle weakness. Individuals who scored between 48 and 37 points on the MRC scale are considered to have significant weaknesses; those with 36 points or less are classified as severely weak. The HGS and the MRC scale will be compared as predictors of weaning duration of mechanical ventilation

Conditions

Muscle Weakness Condition; Mechanical Ventilation Complication; Weaning Failure

Outcome Measures

Primary Outcomes (2)

• mechanical ventilation weaning time

  to evaluate the hand grip strength as a predictor of spontaneous breathing test failure and the duration of mechanical ventilation weaning.

  30 days

• Duration of mechanical ventilation

  to evaluate the Medical Research Council scale as a predictor of spontaneous breathing test failure and the duration of mechanical ventilation. The MRC score is obtained by evaluating 12 muscle groups in the upper extremities (wrist extensors, elbow flexors and abductors of the shoulder) and lower extremities (dorsal ankle flexors, knee extensors, and hip flexors). For each muscle group will be assigned a score between 0 (complete paralysis) and 5 (normal force), and the total score can vary between 0 up to 60 points.

  30 days

Secondary Outcomes (1)

• HGS cut-off points indicative of ICU acquired Weakness

  30 days

Interventions

diagnostic test DIAGNOSTIC_TEST

The overall motor function of the patient will be assessed using the Medical Research Council (MRC) scale and Palmar dynamometer strength

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients on invasive mechanical ventilation for more than 48 hours and ready to perform the spontaneous breathing test.

You may qualify if:

• age over 18 years
• being on invasive mechanical ventilation for more than 48 hours
• fulfill the pre-defined criteria for performing the spontaneous breathing test

You may not qualify if:

• \- patients unable to perform the hand grip strength test and the MRC scale (any rheumatologic conditions, neuromuscular, amputation, cachexia, neuropsychiatric symptoms: such as confusion and delirium)

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead

Study Sites (1)

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035007, Brazil

Location

MeSH Terms

Interventions

Diagnostic Tests, Routine

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Gilberto Friedman, Prof

  Hospital de Clinicas de Porto Alegre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2019
• First Posted: June 19, 2019
• Study Start: March 1, 2016
• Primary Completion: March 30, 2017
• Study Completion: April 30, 2017
• Last Updated: June 19, 2019

Record last verified: 2019-06

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)