NCT03991247

Brief Summary

Persistant insomnia is a common sleep disorder that affects approximately 20% of the French population. The standard treatment for chronic insomnia is Cognitive-Behavioral Therapy (CBT). Behavioral measures can be difficult to implement for the patient alone at home. Spa therapy with psychosomatic orientation allows to implement hygiene rules and structure rhythms of life. In addition, recent studies have shown that spa treatment, including crenotherapy, is effective in somatic complaints related to anxiety and benzodiazepine withdrawal. The spa treatment could therefore provide ideal conditions for the implementation of behavioral measures for insomnia management. The objective of SOMNOTHERM study is to measure efficiency on insomnia complaints at 8 weeks of a the implementation of a Behavioral therapy program for insomnia delivered by an internet software combined to a spa treatment compared to implementation of the same program at home (standard care).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
178

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 17, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 19, 2019

Completed
6 months until next milestone

Study Start

First participant enrolled

December 5, 2019

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2023

Completed
Last Updated

May 31, 2022

Status Verified

May 1, 2022

Enrollment Period

4 years

First QC Date

June 17, 2019

Last Update Submit

May 25, 2022

Conditions

Keywords

Spa treatmentCognitive Behavioral TherapyInternet delivered self-help programInsomniaSleep restrictionstimulus controlcrenotherapy

Outcome Measures

Primary Outcomes (1)

  • Insomnia Severity Scale (ISI) score

    7-item questionnaire assessing insomnia nature, severity and impact. The global score ranges from 0 to 28.

    Week 10 = 8 weeks after beginning of computerized behavioral therapy (starting of time in bed restriction)

Secondary Outcomes (21)

  • Total sleep time (TST) obtained by sleep diary

    Every night between starting of sleep diary completion (Day 0) and Month 6 (study termination)

  • Sleep efficiency (SE) obtained by sleep diary

    Every night between starting of sleep diary completion (Day 0) and Month 6 (study termination)

  • Sleep latency obtained by sleep diary

    Every night between starting of sleep diary completion (Day 0) and Month 6 (study termination)

  • Insomnia Severity Scale (ISI) score

    On Day 0, Week 5, Week 7, Month 4, Month 6

  • EQ-5-D

    On Day 0, Week 5, Week 7, Week 10, Month 4, Month 6

  • +16 more secondary outcomes

Study Arms (2)

Internet Behavioral therapy program + spa therapy

EXPERIMENTAL

Patient following a program of computerized behavioral therapy for insomnia management during a 3 weeks spa treatment.

Behavioral: Computerized behavioral therapy program delivered by internet for insomnia managementOther: Spa treatment

Internet Behavioral therapy program at home

ACTIVE COMPARATOR

Patient following a program of computerized behavioral therapy for insomnia management during 3 weeks at home.

Behavioral: Computerized behavioral therapy program delivered by internet for insomnia management

Interventions

The online program consists in restriction of time in bed and stimulus control instructions. First, patient will complete an on-line sleep diary during 2 weeks. The personalized program is then activated by a practitioner (phone interview) who both assesses restriction of time in bed and delivers instructions of stimulus control. Then, restriction of time in bed is administered by the internet-delivered self-help program. The participant still completes his on-line sleep diary every day. Every 7 days, according mean sleep efficiency, a new sleep schedule recommendation is given to the participant. In addition, the program delivers everyday a set of instructions (stimulus control) designed to re-associate the bed/bedroom with sleep and to re-establish a consistent sleep wake schedule. The duration of restriction of time in bed program is 3 weeks (during spa treatment or at home depending on the allocated arm).

Internet Behavioral therapy program + spa therapyInternet Behavioral therapy program at home

Spa treatment is harmonized in the different stations. It consists in: * a medical thermal follow-up: weekly medical consultation of 15 minutes during the 3 weeks spa treatment. * an institutional follow-up: support, help and monitoring of patients during spa treatment * Crenotherapy: 18 baths of 10 minutes in running water, 18 spa showers of 3 minutes, 9 massages under water of 20 minutes, 18 baths of 10 minutes in pool. Water temperature of pool is between 31°C and 33°C. Water temperature for other care is 35°C and 38°C.

Internet Behavioral therapy program + spa therapy

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male or female aged between 18 and 80 years old
  • Registered at one of the participating spas, for a psychosomatic spa treatment scheduled for the next 12 months, but within a period of more than 16 weeks.
  • ISI score ≥ 8 on the pre-selection questionnaire
  • Person with a persistent insomnia disorder, with or without comorbidities, according to DSM 5
  • Owning or having access to a computer / tablet or smartphone and to an internet connection
  • Affiliated to a national health service
  • Having given written informed consent to participate in the trial.

You may not qualify if:

  • Strong suspicion of obstructive sleep apnea (OSA) syndrome on the STOP-BANG questionnaire and restless legs syndrome on the RLS screening questionnaire
  • Having started antidepressant treatment in the last 2 months or whose treatment dose has been increased in the last 2 months
  • Having started treatment with anxiolytic, hypnotic or neuroleptic in the last month or whose dosage of treatment has been increased in the last month
  • Having carried out a spa treatment in the last 6 months, whatever the specialty.
  • Registered to follow a complementary program for insomnia disorders during the planned spa treatment
  • Pregnant or lactating women
  • Major under guardianship or curatorship
  • Night and shift-workers
  • Having undertaken trans-meridian travel (± 3H) in the previous 1 month

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital, Bordeaux

Bordeaux, 33000, France

RECRUITING

MeSH Terms

Conditions

Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Sleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesMental Disorders

Central Study Contacts

Jean-Arthur MICOULAUD-FRANCHI, MDPhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 17, 2019

First Posted

June 19, 2019

Study Start

December 5, 2019

Primary Completion

December 1, 2023

Study Completion

December 1, 2023

Last Updated

May 31, 2022

Record last verified: 2022-05

Data Sharing

IPD Sharing
Will not share

Patient could request investigator or Data Protection Officer an access to IPD according to French regulation (act No. 78-17 of 6 January 1978 on data processing, data files and individual liberties, amended by act No. 2004-801 of 6 August 2004) and he EU General Data Protection Regulation (GDPR) of 27 april 2016 applicable since 25 May 2018.

Locations