NCT03978273

Brief Summary

Scoliosis is a progressive three-dimensional deformation of the spine during growth, with a prevalence of 80% in girls. The treatments currently used are surgery and rigid brace, which aim to stabilize scoliosis evolution. The place of rehabilitation is disputed because the methods are multiple, non-standardized and the sessions are infrequent. In a previous study (MOUVSCO, NTC02134704), researchers have identified systematic postural abnormalities in patients with scoliosis, and developped a virtual-brace (medical device, MD) to allow real-time self-correction of the trunk position. The aim of the present study is to evaluate for the first time the efficacy of the virtual-brace on the correction of the posture of scoliotic patients. The hypothesis is that intensified rehabilitation with the virtual-brace will improve pathological postures related to scoliosis.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
74

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 15, 2019

Completed
23 days until next milestone

First Posted

Study publicly available on registry

June 7, 2019

Completed
4 months until next milestone

Study Start

First participant enrolled

October 11, 2019

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2023

Completed
Last Updated

March 18, 2020

Status Verified

March 1, 2020

Enrollment Period

3.5 years

First QC Date

May 15, 2019

Last Update Submit

March 17, 2020

Conditions

Keywords

Vertebral columnRehabilitationVirtual-bracePosture

Outcome Measures

Primary Outcomes (1)

  • Medio-lateral displacement during lateral inclination of scoliosis patients in the group with rehabilitation enriched by the virtual brace (group G1) compared with the reference treatment (group G0) at D180.

    Difference between D180 and D0 of the medio-lateral displacement of the pressure center during the lateral inclination in both groups G0 and G1. This parameter is evaluated during the conventional 3D motion capture analysis.

    6 months

Secondary Outcomes (7)

  • Quantification of kinematic, postural and electromyographic anomalies during trunk tilting and rotation (for both groups G0 and G1).

    6 months

  • Quantification of the quality of life evaluated with the Scoliosis Research Society Patient questionnaire (SRS-22), for both groups G0 and G1.

    6 months

  • Quantification of kinematic feedback provided by the virtual-brace and their deviation from the prescription (only for group G1)

    6 months

  • Treatment compliance for the rigid-brace (for both group G1 and G0)

    6 months

  • Treatment compliance for the virtual-brace (only for group G1)

    6 months

  • +2 more secondary outcomes

Study Arms (2)

Night-time brace + virtual-brace

EXPERIMENTAL

Patients are conventionally treated with night-time brace. Additionally, they use the new developped virtual-brace (MD).

Device: Night-time brace + virtual-brace

Night-time brace only

ACTIVE COMPARATOR

Patients are conventionally treated with night-time brace only.

Other: Night-time brace only

Interventions

Patients will receive conventional treatment : wearing a night-time brace every night during 6 months. Additionally : * They will perform 5 sessions of postural rehabilitation exercises per week (each of 30 minutes) with the virtual-brace (MD). * They will have also follow up consultations with a physiotherapist every 21 days, to evaluate treatment observance and to adapt postural exercises according to the results and difficulties encountered. Conventional 3D motion capture Analysis (different trunk tasks and walk) will be performed to evaluate evolution of postural parameters at D0, D90 and D180.

Night-time brace + virtual-brace

Patients will receive conventional treatment : wearing a night-time brace every night during 6 months. Conventional 3D motion capture Analysis (different trunk tasks and walk) will be performed to evaluate evolution of postural parameters at D0, D90 and D180.

Night-time brace only

Eligibility Criteria

Age9 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Patients with idiopathic scoliosis (left lumbar or right thoracic),
  • Patients with moderate scoliosis: Cobb angle assessed on the last radiography between 20 ° and 35 °,
  • Patients requiring the wearing of a rigid night-time brace,
  • Patients having a home computer,
  • Patients affiliated to social security or similarly regime,
  • Patients who gave their consent to participate in the study,
  • Patients whose 2 parents have signed the informed consent

You may not qualify if:

  • Patients with an unstabilized medical problem,
  • Patients with known allergy to elastane,
  • Patients with sensitivity to dizziness,
  • Patients with pacemaker,
  • Patients with implanted cardiac defibrillator,
  • Patients with cochlear implant,
  • Patients carrying a non-removable metal element,
  • Protected patient concerned by articles L1121-5 and L1121-6 of the Public Health Code,
  • Patients whose parents are protected by article L1121-8 of the Public Health Code

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Grenoble

Grenoble, 38043, France

RECRUITING

Study Officials

  • Aurelien COURVOISIER, MD, PhD

    University Hospital, Grenoble

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Aurelien COURVOISIER, MD, PhD

CONTACT

Emilie CHIPON, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 15, 2019

First Posted

June 7, 2019

Study Start

October 11, 2019

Primary Completion

April 1, 2023

Study Completion

April 1, 2023

Last Updated

March 18, 2020

Record last verified: 2020-03

Data Sharing

IPD Sharing
Will not share

Locations