NCT03972475|Completed
The Effect of Maintenance Fluids on Overall Fluid Balance in ICU Patients
A Multi Center Observational Study on the Effects of Maintenance Fluids on Overall Fluid Balance in ICU Patients.
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A Multi Center Observational Study on the Effects of Maintenance Fluids on Overall Fluid Balance in ICU Patients.
Sponsor study identifier
NIH
observational
200
1 country
6
Study Start
January 1, 2018
Actual (reported)Primary Completion
December 31, 2019
Actual (reported)Study Completion
April 15, 2020
Actual (reported)The amount of fluids characterized as non-resuscitation fluids given to ICU patients are likely to be high and will probably have a substantial impact on the total amount of fluid administered to ICU patients daily. It will most likely also influence on the total fluid balance and the negative outcome of fluid overload. The aim of our study is to investigate the amount of fluid given as maintenance fluids in the ICU and the impact of this fluid on total fluid balance.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 15, 2020
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2018
Actual (reported)May 24, 2019
Actual (reported)June 3, 2019
Actual (reported)December 31, 2019
Actual (reported)April 15, 2020
Actual (reported)Fluid balance
To register the volume of fluid given to ICU patients categorized as resuscitation fluid, fluid to cover basal needs and nutrition and as fluid given to administer drugs and keeping intravenous accesses functioning. This will be measured i milliliters of fluid that the patients receive intravenously and orally by studying patient charts manually from their stay in the ICU.
One week
Fluid needs vs actual fluids given
One week
Electrolyte
One week
All patients that spend one week or more in the general ICUs at the included hospitals. Data will be collected from day 3 of the ICU stay until day 7.
Contact the study team to confirm eligibility.
ICU, Karolinska Hospital Huddinge
Huddinge, Stockholm County, 14157, Sweden
ICU, Karolinska hospital Solna
Solna, Stockholm County, 17176, Sweden
ICU, Mälarsjukhuset Eskilstuna
Eskilstuna, 63188, Sweden
ICU, Gävle Hospital
Gävle, 80324, Sweden
ICU, Sahlgrenska University Hospital
Gothenburg, 41345, Sweden
Central ICU (CIVA), Uppsal university hospital
Uppsala, 75185, Sweden
Nihlen S, Frithiof R, Titze J, Kawati R, Rasmusson J, Rylander C, Pikwer A, Castegren M, Belin A, Hultstrom M, Lipcsey M. The Contribution of Plasma Urea to Total Osmolality During Iatrogenic Fluid Reduction in Critically Ill Patients. Function (Oxf). 2021 Oct 29;3(1):zqab055. doi: 10.1093/function/zqab055. eCollection 2022.
Nihlen S, Kawati R, Rasmusson J, Rylander C, Pikwer A, Castegren M, Belin A, Lipcsey M. Hidden sources of fluids, sodium and potassium in stabilised Swedish ICU patients: A multicentre retrospective observational study. Eur J Anaesthesiol. 2021 Jun 1;38(6):625-633. doi: 10.1097/EJA.0000000000001354.
Blood samples
Miklos Lipcsey, Assoc prof
Uppsala University
200 participants (actual enrollment reported by the registry).
First Submitted
May 24, 2019
First Posted
June 3, 2019
Study Start
January 1, 2018
Actual (reported)Effects of Fluid Balance Control in Critically Ill Patients
Primary Completion
December 31, 2019
Actual (reported)Study Completion
April 15, 2020
Actual (reported)Last Updated
April 29, 2020
Record last verified: 2020-04
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