The Effect of Maintenance Fluids on Overall Fluid Balance in ICU Patients
A Multi Center Observational Study on the Effects of Maintenance Fluids on Overall Fluid Balance in ICU Patients.
1 other identifier
observational
200
1 country
6
Brief Summary
The amount of fluids characterized as non-resuscitation fluids given to ICU patients are likely to be high and will probably have a substantial impact on the total amount of fluid administered to ICU patients daily. It will most likely also influence on the total fluid balance and the negative outcome of fluid overload. The aim of our study is to investigate the amount of fluid given as maintenance fluids in the ICU and the impact of this fluid on total fluid balance.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2018
Typical duration for all trials
6 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2018
CompletedFirst Submitted
Initial submission to the registry
May 24, 2019
CompletedFirst Posted
Study publicly available on registry
June 3, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
April 15, 2020
CompletedApril 29, 2020
April 1, 2020
2 years
May 24, 2019
April 28, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Fluid balance
To register the volume of fluid given to ICU patients categorized as resuscitation fluid, fluid to cover basal needs and nutrition and as fluid given to administer drugs and keeping intravenous accesses functioning. This will be measured i milliliters of fluid that the patients receive intravenously and orally by studying patient charts manually from their stay in the ICU.
One week
Secondary Outcomes (2)
Fluid needs vs actual fluids given
One week
Electrolyte
One week
Eligibility Criteria
All patients that spend one week or more in the general ICUs at the included hospitals. Data will be collected from day 3 of the ICU stay until day 7.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (6)
ICU, Karolinska Hospital Huddinge
Huddinge, Stockholm County, 14157, Sweden
ICU, Karolinska hospital Solna
Solna, Stockholm County, 17176, Sweden
ICU, Mälarsjukhuset Eskilstuna
Eskilstuna, 63188, Sweden
ICU, Gävle Hospital
Gävle, 80324, Sweden
ICU, Sahlgrenska University Hospital
Gothenburg, 41345, Sweden
Central ICU (CIVA), Uppsal university hospital
Uppsala, 75185, Sweden
Related Publications (2)
Nihlen S, Frithiof R, Titze J, Kawati R, Rasmusson J, Rylander C, Pikwer A, Castegren M, Belin A, Hultstrom M, Lipcsey M. The Contribution of Plasma Urea to Total Osmolality During Iatrogenic Fluid Reduction in Critically Ill Patients. Function (Oxf). 2021 Oct 29;3(1):zqab055. doi: 10.1093/function/zqab055. eCollection 2022.
PMID: 35330925DERIVEDNihlen S, Kawati R, Rasmusson J, Rylander C, Pikwer A, Castegren M, Belin A, Lipcsey M. Hidden sources of fluids, sodium and potassium in stabilised Swedish ICU patients: A multicentre retrospective observational study. Eur J Anaesthesiol. 2021 Jun 1;38(6):625-633. doi: 10.1097/EJA.0000000000001354.
PMID: 33074941DERIVED
Biospecimen
Blood samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Miklos Lipcsey, Assoc prof
Uppsala University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Target Duration
- 90 Days
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 24, 2019
First Posted
June 3, 2019
Study Start
January 1, 2018
Primary Completion
December 31, 2019
Study Completion
April 15, 2020
Last Updated
April 29, 2020
Record last verified: 2020-04