Neutral and Positive Attention Bias Modification Training for Young Adults With Depressive Symptoms

NCT03971942 | Completed DMC

• 1 other identifier: ABM2017
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

This study intends to explore the therapeutic effects of the development of negative attention bias modifaction and positive attention bias on depressive symptoms and redundancy through two different attention training methods: (1) neutral attention training (when neutral and sad stimuli are presented simultaneously, attention is always directed towards neutral stimuli to correct negative attention bias) and (2) positive attention training (when neutral and positive stimuli are presented simultaneously, attention is always directed towards positive stimuli to develop positive attention bias).

Conditions

Depressive Disorder

Keywords

attention bias modification; positive attention bias; depressive symptoms; prevention

Outcome Measures

Primary Outcomes (2)

• Changes of attentional bias score

  Attentional bias score tested by a typical dot-probe task

  pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)

• Changes of depressive symptoms

  Depression symptoms tested by clinicians using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS)

  pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)

Secondary Outcomes (2)

• Changes of self-reported depressive symptoms

  pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)

• Changes of self-reported rumination

  pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)

Study Arms (2)

Neutral ABMT

EXPERIMENTAL

8-session-ABMT during a two-week period and 4-session-booster-ABMT during a two-week period

Behavioral: Neutral ABMT

Positive ABMT

EXPERIMENTAL

8-session-ABMT during a two-week period and 4-session-booster-ABMT during a two-week period

Behavioral: Positive ABMT

Interventions

Neutral ABMT BEHAVIORAL

In the neutral attention bias, there are 108 pairs of neutral-negative words, 54 pairs of which are used in the training group and 54 pairs of which are used in the placebo group. The word pairs in each group are repeated 4 times, with a total of 216 trial. Participants received 8 sessions over 2 weeks (1 session every other day).In booster ABMT, participants received 4 sessions over 2 weeks (1 session every three days).90% of the targets in the training group appear in the neutral word position and 10% of the targets appear in the negative word position, while 50% of the targets in the placebo group appear in the neutral word position and 50% of the targets appear in the negative word position.

Neutral ABMT

Positive ABMT BEHAVIORAL

In the positive attention bias, there are 54 pairs of neutral-negative words, 27 pairs of which are used in the training group and 27 pairs of which are used in the placebo group. The word pairs in each group are repeated 8 times, with a total of 216 trial.Participants received 8 sessions over 2 weeks (1 session every other day). In booster ABMT, participants received 4 sessions over 2 weeks (1 session every three days).90% of the targets in the training group appear in the positive word position and 10% of the targets appear in the neutral word position, while 90% of the targets in the placebo group appear in the neutral word position and 10% of the targets appear in the positive word position.

Positive ABMT

Eligibility Criteria

• Age: 16 Years - 20 Years
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• A score of 14 or higher on the Beck Depression Inventory-Ⅱ

You may not qualify if:

• a current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder;
• any concurrent psychotherapy;
• any concurrent psychotropic medication.

Sponsors & Collaborators

• Hunan Normal University: lead

Study Sites (1)

Department of Psychology, Hunan Normal University

Changsha, Hunan, 410081, China

Location

MeSH Terms

Conditions

Depressive Disorder; Depression

Condition Hierarchy (Ancestors)

Mood Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Psychology

Study Record Dates

• First Submitted: March 26, 2019
• First Posted: June 3, 2019
• Study Start: December 24, 2017
• Primary Completion: January 22, 2019
• Study Completion: March 30, 2019
• Last Updated: June 3, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE

Locations

CN (1)