Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium

NCT03968887 | Unknown

• 1 other identifier: 2019-092
• Study Type: observational
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

Postoperative delirium (POD) refers to an acute neurocognitive disorder that occurs within 1 week after surgery or before discharge. Old age is one of the important risk factors for postoperative delirium. The incidence rate of the elderly is high, and the life span of human beings is increasing. Postoperative delirium has adverse effects on both short-term and long-term outcomes, including mortality, ability to work, and dependence on society. Low-density lipoprotein (LDL) is a key molecule in the cholesterol transport mechanism and is easily oxidized to oxidized low-density lipoprotein (OxLDL). Oxidized low density lipoproteins are immunogenic and are also cytotoxic to endothelial cells. Some studies have shown that increased oxidative stress is one of the earliest changes in disease, and similar signs can be detected in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), such as protein oxidation and lipids. An increase in the quality of the peroxidation index. For the study of anesthesiology, oxidative stress theory has long been recognized as one of the mechanisms of postoperative delirium. We have a hypothesis that plasma oxidized low-density lipoprotein levels are associated with postoperative delirium and can be used as an early warning marker for disease occurrence. Based on clinical research data, we conducted a prospective cohort study to explore the correlation between plasma oxidized low-density lipoprotein levels and postoperative sputum, providing clinical prediction and diagnostic value.

Conditions

Postoperative Delirium

Keywords

Postoperative Delirium

Outcome Measures

Primary Outcomes (2)

• plasma oxidized low-density lipoprotein levels

  Preoperative plasma oxidized low-density lipoprotein levels

  through study completion, an average of 4 months

• plasma oxidized low-density lipoprotein levels

  Postoperative plasma oxidized low-density lipoprotein levels

  through study completion, an average of 4 months

Study Arms (2)

Case group

Patients with postoperative delirium.

Other: plasma oxidized low-density lipoprotein levels

Control group

Patients who have not had postoperative delirium.

Other: plasma oxidized low-density lipoprotein levels

Interventions

plasma oxidized low-density lipoprotein levels OTHER

Detection of plasma oxidized low-density lipoprotein levels

Case group; Control group

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients in orthopedics, urology and general surgery .

You may qualify if:

• Surgical treatment was performed in our hospital under standard anesthesia.
• Patients in orthopedics, urology and general surgery.

You may not qualify if:

• Patients with mental illness or taking psychotropic substances before surgery.
• Preoperative dementia or cognitive dysfunction.
• Unable to communicate and cooperate with patients due to coma, language barrier or end-stage disease before surgery.
• ASA greater or equal to 4.
• Patients who have undergone neurosurgery and cardiac vascular surgery.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Lina Yu, MD

CONTACT

+86 13958033387; zryulina@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 19, 2019
• First Posted: May 30, 2019
• Study Start: May 20, 2019
• Primary Completion: September 20, 2019
• Study Completion: September 20, 2019
• Last Updated: May 30, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share