NCT03967847

Brief Summary

  1. 1.The investigators aim to examine the use of IV and oral ketorolac as an adjunctive agent to the standard of care pain protocol for postoperative pain control following arthroscopic rotator cuff repair.
  2. 2.The investigators hypothesize that the use of IV and oral ketorolac in addition to the standard of care pain protocol will reduce postoperative opioid consumption following arthroscopic rotator cuff repair.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
44

participants targeted

Target at below P25 for phase_3

Timeline
Completed

Started Feb 2019

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 11, 2019

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

May 27, 2019

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 30, 2019

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 14, 2020

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 17, 2021

Completed
12 months until next milestone

Results Posted

Study results publicly available

May 10, 2022

Completed
Last Updated

May 10, 2022

Status Verified

April 1, 2022

Enrollment Period

1.7 years

First QC Date

May 27, 2019

Results QC Date

November 3, 2021

Last Update Submit

April 14, 2022

Conditions

Keywords

Rotator Cuff TearPostoperative Pain

Outcome Measures

Primary Outcomes (1)

  • Postoperative Visual Analog Scale Scores

    The Visual Analog Scale ranges from a minimum score of 0 to a maximum score of 100. A smaller score would be considered a better outcome.

    participants were assessed at one single time point up to 8 weeks.

Secondary Outcomes (1)

  • Number of Participants With Retear of Rotator Cuff Repair

    6 months

Study Arms (2)

Control

NO INTERVENTION

Ketorolac

EXPERIMENTAL
Drug: Ketorolac

Interventions

Oral Ketorolac

Ketorolac

Eligibility Criteria

Age18 Years - 89 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients between the ages of 18 and 89 years old, male or female
  • Patients undergoing primary shoulder arthroscopic rotator cuff repair

You may not qualify if:

  • Patients below the age of 18 or above the age of 89
  • Illiterate or non-English speaking patients
  • Patients with contraindications to Ketorolac
  • History of alcohol of drug abuse
  • Chronic use of analgesic or psychotropic drugs
  • Known peptic ulcer disease or bleeding diathesis
  • Renal dysfunction

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

Location

MeSH Terms

Conditions

Rotator Cuff InjuriesPain, Postoperative

Interventions

Ketorolac

Condition Hierarchy (Ancestors)

RuptureWounds and InjuriesShoulder InjuriesTendon InjuriesPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Intervention Hierarchy (Ancestors)

IndomethacinIndolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Results Point of Contact

Title
John Strony, MD
Organization
University Hospitals Cleveland Medical Center

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

May 27, 2019

First Posted

May 30, 2019

Study Start

February 11, 2019

Primary Completion

October 14, 2020

Study Completion

May 17, 2021

Last Updated

May 10, 2022

Results First Posted

May 10, 2022

Record last verified: 2022-04

Data Sharing

IPD Sharing
Will not share

Locations