Intravenous Ascorbic Acid Administration in Hysterectomy
Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy
1 other identifier
interventional
80
1 country
1
Brief Summary
vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water\_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3
Started Aug 2019
Shorter than P25 for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 26, 2019
CompletedFirst Posted
Study publicly available on registry
May 29, 2019
CompletedStudy Start
First participant enrolled
August 23, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 30, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2020
CompletedMay 4, 2020
April 1, 2020
5 months
May 26, 2019
April 29, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
volume of hemorrhage
volume of hemorrhage during surgery
During surgery
Secondary Outcomes (4)
Hemoglobin value
6 and 24 hours after surgery
wound healing
during 2 weeks post surgery
duration of stay in hospital
up to 2 weeks post surgery
Infection
up to 2 weeks post surgery
Study Arms (2)
vitamin C
EXPERIMENTALIntervention patients will be received double dose of Ascorbic acid via intravenous injection
Control
NO INTERVENTIONControl patients will not be received any intervention
Interventions
water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection
Eligibility Criteria
You may qualify if:
- To be 18 years and older
- No smoking
- No history of bleeding disorder
- No history of favism
- No history of uterus, ovary, cervical cancer
You may not qualify if:
- Need to injection of vasopressor drugs
- Surgeon disagreement
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences
Tehran, Iran
Related Publications (1)
Farahani-Jam S, Yaghmaei M, Vahdat Shariatpanahi Z. Effect of intravenous ascorbic acid administration on hemorrhage and wound complications in total abdominal hysterectomy: A prospective randomized clinical trial. Clin Nutr ESPEN. 2022 Jun;49:74-78. doi: 10.1016/j.clnesp.2022.03.024. Epub 2022 Mar 26.
PMID: 35623878DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
zahra vahdat shariatpanahi, MD,PhD
Associatec professor
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
May 26, 2019
First Posted
May 29, 2019
Study Start
August 23, 2019
Primary Completion
January 30, 2020
Study Completion
January 30, 2020
Last Updated
May 4, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share