NCT03961802

Brief Summary

A prospective, monocentric, controlled, randomized study of systematic early shoulder rehabilitation following cervical lymph node dissection for the prevention and treatment of shoulder dysfunction.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 8, 2019

Completed
3 months until next milestone

First Posted

Study publicly available on registry

May 23, 2019

Completed
1 month until next milestone

Study Start

First participant enrolled

July 2, 2019

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 16, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 16, 2023

Completed
Last Updated

January 24, 2024

Status Verified

January 1, 2024

Enrollment Period

4.4 years

First QC Date

March 8, 2019

Last Update Submit

January 23, 2024

Conditions

Keywords

Rehabilitationshoulder dysfunctioncervical lymph node dissectionhead and neck cancer

Outcome Measures

Primary Outcomes (1)

  • Disabilities of Shoulder, Arm and Hand Questionnaire (DASH)

    The total score is reported. The score is between 0 and 100. The higher the score, the higher the disability.

    6 months postoperatively (M6)

Secondary Outcomes (8)

  • Disabilities of Shoulder, Arm and Hand Questionnaire (DASH)

    3 and 12 months postoperatively (M3 and M12)

  • visual analog score for pain (M3, M6 and M12)

    3, 6 and 12 months postoperatively (M3, M6 and M12)

  • goniometric measurement of flexion and abduction of the shoulder

    3, 6 and 12 months postoperatively (M3, M6 and M12)

  • European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

    3, 6 and 12 months postoperatively (M3, M6 and M12)

  • European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

    3, 6 and 12 months postoperatively (M3, M6 and M12)

  • +3 more secondary outcomes

Study Arms (2)

systematic early rehabilitation

EXPERIMENTAL

systematic early rehabilitation

Other: sessions of shoulder rehabilitation

without systematic rehabilitation

NO INTERVENTION

without systematic rehabilitation

Interventions

3 sessions of shoulder rehabilitation per week for 3 months (36 sessions)

systematic early rehabilitation

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Proficiency in the oral and written French language
  • unilateral or bilateral cervical lymph node dissection preserving the accessory spinal nerve
  • Karnofsky index ≥ 80%
  • Age ≥ 18 years

You may not qualify if:

  • cognitive disorders
  • predictable difficulties in compliance with treatment and/or follow-up
  • pre-existing pathology involving shoulder and its mobility, independent of head and neck cancer
  • comorbidity preventing rehabilitation of the shoulder
  • time to start rehabilitation after 6 weeks postoperatively
  • pregnant women
  • minors
  • majors under guardianship
  • refusal to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Nantes University Hospital

Nantes, 44093, France

Location

MeSH Terms

Conditions

Head and Neck Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 8, 2019

First Posted

May 23, 2019

Study Start

July 2, 2019

Primary Completion

November 16, 2023

Study Completion

November 16, 2023

Last Updated

January 24, 2024

Record last verified: 2024-01

Locations