Trials Sponsors Conditions Drugs Pricing

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

AltitudeHypobaric hypoxiaAltitude-related illnessPrevention

Outcome Measures

Primary Outcomes (1)

Diagnostic accurarcy measures of structured self-monitoring
Diagnostic performance includes sensitivity, specificity, positive and negative predictive values, and receiver operator curve area under the the curve. The diagnostic performance will be compared statistically using c-statistics against the reference test. Reference test will be the occurence of altitude-related illness defined as the following: * AMS defined by the Lake Louise questionnaire score or with AMSc score * severe hypoxemia (SpO2 \<80% at rest \>30 min; or SpO2 \<75% at rest \>15 min; * intercurrent illness that cannot be relieved by simple measures such as paracetamol 3x500 mg/day, inhalation of bronchodilators. * dyspnea or discomfort at rest requiring treatment with oxygen * chest pain or ECG signs of cardiac ischemia * severe hypertension: systolic blood pressure \>200 mmHg, diastolic blood pressure \>110 mmHg * new onset neurologic impairment * Any condition that requires study withdrawal according to the decision of the independent physician
Day 1 to 3 at 3100m

Secondary Outcomes (6)

Acute mountain sickness severity assessed by the Lake Louise score
Day 1 to 3 at 3100m
Altitude-related illness, incidence
Day 1 to 3 at 3100m
Spirometric measurement of forced expiratory volume in one second
Day 2 at 760 and 3100m
Arterial partial pressure of oxygen
Day 2 at 760 and 3100m
Six-minute walk distance in meters
Day 2 at 760 and 3100m
+1 more secondary outcomes

Study Arms (1)

COPD patients

Diagnostic Test: Structured self-monitoring during an altitude ascent and stay at high altitude

Interventions

Structured self-monitoring during an altitude ascent and stay at high altitudeDiagnostic test

Structured self-monitoring by a symptom checklist in combination with a pulse oximeter worn at the wrist in lowlanders with COPD ascending from low altitude (760m) to high altitude (3100m).

COPD patients

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 75 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

Patients with COPD, FEV1 40-80% predicted living at low altitude.

You may qualify if:

Male and female patients, age 18-75 yrs.

Sponsors & Collaborators

National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Governmentcollaborator
University of Zurich
Otherlead

Study Sites (1)

National Center of Cardiology and Internal Medicine

Bishkek, Kyrgyzstan

Related Publications (1)

Furian M, Reiser AE, Mademilov M, Sutter S, Champigneulle B, Grimm M, Magdieva K, Beishenaliev AS, Sooronbaev TM, Ulrich S, Bloch KE. Self-monitoring symptoms and pulse oximetry to predict imminent altitude illness in patients with chronic obstructive pulmonary disease. Pulmonology. 2026 Dec;32(1):2588515. doi: 10.1080/25310429.2025.2588515. Epub 2025 Dec 23.
PMID: 41433778DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

Konrad E Bloch, MD
University of Zurich
STUDY CHAIR
Talant M Sooronbaev, MD
National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
STUDY DIRECTOR

Enrollment

153 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE ONLY
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

May 16, 2019

First Posted

May 21, 2019

Study Start

May 20, 2019

Actual (reported)

Early Signs of Altitude Illness in Patients With COPD

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (1)

COPD patients

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (1)

COPD patients

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations