NCT03956264

Brief Summary

This study compares Virtual Reality versus Nitrous oxide administration for the management of anxiety and pain related to post-cardiac surgery care, especially during removal of mediastinal drainage.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 16, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 20, 2019

Completed
4 months until next milestone

Study Start

First participant enrolled

September 26, 2019

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 24, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 24, 2020

Completed
Last Updated

April 8, 2026

Status Verified

April 1, 2026

Enrollment Period

10 months

First QC Date

May 16, 2019

Last Update Submit

April 2, 2026

Conditions

Keywords

PainAnxietyMediastinal drain removal

Outcome Measures

Primary Outcomes (1)

  • Assessment of patient comfort

    Variation of the Analgesia / Nociception Index (ANI)

    30 minutes

Secondary Outcomes (9)

  • Level of pain during drain removal

    30 minutes

  • Level of anxiety during drain removal

    30 minutes

  • Morphine consumption

    1 hour

  • Side effects due to Virtual Reality

    2 hours

  • Patient satisfaction

    2 hours

  • +4 more secondary outcomes

Study Arms (2)

VR

EXPERIMENTAL

VR Installation 5 min before the drain removal and stop 10 min after the procedure. If Pain assessed by numerical rating scale (NRS) \> 4, administration of morphine.

Device: Virtual Reality

Kalinox®

ACTIVE COMPARATOR

Start of Kalinox® administration by inhalation with a facial mask 1 min before the drain removal and stop after the procedure according to the usual procedure of the service. If Pain NRS \> 4, administration of morphine.

Drug: Kalinox

Interventions

Deepsen offers a VR platform that provides patients with immersive contents aimed to distract, inform, soften and improve the healthcare experience

VR

Gas mixture composed of 50% Nitrous Oxide and 50% Oxygen

Kalinox®

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Extubated after cardiac surgery
  • Sinus rhythm
  • Consent for participation
  • Affiliation to the social security system

You may not qualify if:

  • Pacemaker
  • Visual acuity making impossible the use of virtual reality
  • Intolerance to morphine
  • Contraindication to Kalinox®
  • Pregnant or breastfeeding women
  • Patients under protection of the adults (guardianship, curators or safeguard of justice)
  • Communication difficulties or neuropsychiatric disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CMC Ambroise Paré

Neuilly-sur-Seine, Île-de-France Region, 92200, France

Location

Related Publications (1)

  • Laghlam D, Naudin C, Coroyer L, Aidan V, Malvy J, Rahoual G, Estagnasie P, Squara P. Virtual reality vs. Kalinox(R) for management of pain in intensive care unit after cardiac surgery: a randomized study. Ann Intensive Care. 2021 May 13;11(1):74. doi: 10.1186/s13613-021-00866-w.

MeSH Terms

Conditions

PainAnxiety Disorders

Interventions

kalinox

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 16, 2019

First Posted

May 20, 2019

Study Start

September 26, 2019

Primary Completion

July 24, 2020

Study Completion

July 24, 2020

Last Updated

April 8, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations