NCT03954574|RecruitingDMC
Pulmonary Hemodynamics During Exercise - Research Network
PEX-NET
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PEX-NET
Sponsor study identifier
observational
1,500
14 countries
32
Study Start
December 1, 2018
Actual (reported)Primary Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 1, 2018
Actual (reported)March 14, 2019
Actual (reported)May 17, 2019
Actual (reported)December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Number of Participants who die during observation
The investigators aim to assess the prognostic relevance of pulmonary hemodynamics during exercise as assessed by right heart catheterization by using a multi-centre approach and to identify independent predictors of adverse events. Separate data sets will be analysed for the retrospective and prospective Evaluation.
6 years
Number of Participants undergoing lung Transplantation during observation
Occurrences of lung transplantations
6 years
Number of Participants being hospitalized during observation
6 years
Number of Participants who develop pulmonary Hypertension as assessed by right heart catheterization
6 years
Number of Participants with newly initiated pulmonary arterial Hypertension medication during observation
6 years
all patients undergo right heart catheterization during exercise due to clinical reasons. Results of this and other Routine clinical tests will be included in the registry
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for right heart catheterization at rest and exercise
University of Arizona, Banner University Medical Center
Phoenix, Arizona, 85724, United States
University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine
Los Angeles, California, 90095, United States
Horst Olschewski, MD
Medical University of Graz
Philippe Herve, MD
Centre Chirugical Marie Lannelongue
First Submitted
March 14, 2019
First Posted
May 17, 2019
Study Start
December 1, 2018
Actual (reported)Primary Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Contact the study team to confirm eligibility.
Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA
Baltimore, Maryland, 21287, United States
Massachusetts General Hospital, Cardiology Division and Pulmonary Unit
Boston, Massachusetts, 02114, United States
Harvard Medical School, Brigham and Women's Hospital
Boston, Massachusetts, 02138, United States
University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA
Minneapolis, Minnesota, 55455, United States
Mayo Clinic, Division of Cardiovascular Diseases, Department of Medicine
Rochester, Minnesota, 85259, United States
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Royal Prince Alfred Hospital, Respiratory Medicine
Camperdown, Australia
Medical University of Graz
Graz, Austria
Free University of Brussels, Faculty of Medicine, Physiology
Brussels, Belgium
University of São Paulo Medical School
São Paulo, Brazil
Department of Cardiology, Aarhus University Hospital, Denmark
Aarhus, Denmark
Université de Lorraine
Nancy, France
Centre Chirurgical Marie Lannelongue, Thoracic and Vascular Surgery
Paris, France
Centre de Référence de l'Hypertension Pulmonaire, Université ParisSud - Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris
Paris, France
Sorbonne Universités, Neurophysiologie respiratoire expérimentale et clinique
Paris, France
University of Cologne, Klinik III fuer Innere Medizin
Cologne, Germany
Justus-Liebig-University Giessen, Department of Internal Medicine
Giessen, Germany
University of Greifswald
Greifswald, Germany
Thorax Clinic Heidelberg, Centre for Pulmonary Hypertension
Heidelberg, Germany
Academic Teaching Hospital of the Julius Maximilian University of Würzburg
Würzburg, Germany
University of Bologna
Bologna, Italy
University of Rome La Sapienza, Cardiovascular and Respiratory Sciences
Roma, Italy
VU Medisch Centrum, Pulmonology
Amsterdam, Netherlands
Otwock Medical Center of Postgraduate Education, Department of Pulmonary Circulation and Thromboembolic Diseases
Otwock, Poland
Barcelona Hospital Clínic, Pneumologia
Barcelona, Spain
University Hospital of Zurich, Internal Medicine
Zurich, Switzerland
Scottish Pulmonary Vascular Unit
Glasgow, United Kingdom
Imperial College, NHS Healthcare NHS Trust, National Pulmonary Hypertension Service
London, United Kingdom
Royal Brompton Hospital
London, United Kingdom
Royal Hallamshire Hospital, Sheffield Pulmonary Vascular Disease Unit
Sheffield, United Kingdom
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 27, 2025
Record last verified: 2025-04
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Source: ClinicalTrials.gov.
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