Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load
1 other identifier
interventional
300
1 country
1
Brief Summary
The aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 1, 2019
CompletedStudy Start
First participant enrolled
May 1, 2019
CompletedFirst Posted
Study publicly available on registry
May 15, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2020
CompletedMay 15, 2019
May 1, 2019
1 year
May 1, 2019
May 13, 2019
Conditions
Outcome Measures
Primary Outcomes (3)
Genetic Changes in Knee Muscle and Tendon
Comparison of results of genetic testing both before and after interventions between the 3 groups
One year
Ultrasound Changes in Knee Muscle and Tendon
Comparison of results of pre- and post ultrasound changes after interventions between the 3 groups
One year
Biopsy Changes in Knee Muscle and Tendon
Comparison of changes in biopsies taken before and after interventions between the 3 groups
One year
Study Arms (3)
One acute resistance load exercise
ACTIVE COMPARATOROne hundred volunteers will participate in one acute resistance load exercises to their quadriceps
Three acute resistance load exercises
ACTIVE COMPARATOROne hundred volunteers will participate in three acute resistance load exercises to their quadriceps
Control Group
ACTIVE COMPARATOROne hundred volunteers will participate in study as a control group
Interventions
Leg bench and leg press acute resistant load exercises Leg-bench and leg-press acute resistant load exercises
Background questionnaire will be filled out by participants
Pain questionnaire regarding pain in the knee during previous 3 months
DNA and RNA tests will be sent to a genetic laboratory for analysis
Ultrasound of the knee joint and the quadriceps muscle and the pica tendon
Core Biopsy will be taken from the quadriceps femoris muscle
Eligibility Criteria
You may qualify if:
- Non-professional athletes
- Pass heart/lung endurance tests
- Pass ergometrics testing
You may not qualify if:
- Have been injured
- Had physiotherapy for back or lower limbs in past 6 months
- Orthopedic surgery in lower limbs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hillel Yaffe Medical Center
Hadera, 38100, Israel
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 1, 2019
First Posted
May 15, 2019
Study Start
May 1, 2019
Primary Completion
May 1, 2020
Study Completion
May 1, 2020
Last Updated
May 15, 2019
Record last verified: 2019-05
Data Sharing
- IPD Sharing
- Will not share