Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC)

NCT03950089 | Completed

• 1 other identifier: OCTA CSC
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

Optical Coherence Tomography Angiography (OCT-A) is a noninvasive imaging technique that allows one to see blood vessels in the retina. The investigating team used this approach in patients with acute, recurrent and persistent subtypes of Central Serous Chorioretinopathy (CSC) to check for possible Choriocapillaris hypoperfusion. The presence or absence of these microvascular changes was explored in both eyes of the patients and compared to a control group of healthy volunteers. The possibility of a correlation between Choriocapillaris flow deficits, age and spontaneous resolution of serous retinal detachment was also evaluated. This study was conducted in an effort to improve one's understanding of this disease and other pachychoroid disorders.

Conditions

Central Serous Chorioretinopathy

Outcome Measures

Primary Outcomes (2)

• Total number average individual area of flow signal voids

  3x3 Optical Coherence Tomography Angiography (OCT-A) images on choriocapillaris slab were exported from the Angioplex software and then imported into the open-source Fiji software. Each image was binarized in black and white pixels. Thresholded areas greater than or equal to 1 white pixel were considered as flow signal voids

  2 months

• Total area of flow signal voids

  3x3 Optical Coherence Tomography Angiography (OCT-A) images on choriocapillaris slab were exported from the Angioplex software and then imported into the open-source Fiji software. Each image was binarized in black and white pixels. Thresholded areas greater than or equal to 1 white pixel were considered as flow signal voids

  2 months

Study Arms (2)

Patients with Central Serous Chorioretinopathy

Device: Optical Coherence Tomography Angiography (OCT-A)

Healthy patients

Device: Optical Coherence Tomography Angiography (OCT-A)

Interventions

Optical Coherence Tomography Angiography (OCT-A) DEVICE

Optical Coherence Tomography Angiography (OCT-A) images were acquired using an Spectral Domain Optical Coherence Tomography device (Cirrus High Definition OCT Model 5000 with Angioplex; Carl Zeiss Meditec, Dublin, California, USA). With an acquisition speed of 68,000 A-Scan per second, the OCT Microangiography Complex algorithm provided OCT-A information for three-dimensional (3D) flow reconstruction. At each visit, each subject underwent a 3 x 3 millimeter (mm) macular 3D cube acquisition in both eyes. FastTrac continuous eye tracking technology was employed to control for eye movements and minimize motion artefacts.

Healthy patients; Patients with Central Serous Chorioretinopathy

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute, recurrent or persistent forms of central serous chorioretinopathy

You may qualify if:

• Patients with acute, recurrent or persistent forms of central serous chorioretinopathy

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

MeSH Terms

Conditions

Central Serous Chorioretinopathy

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases

Study Officials

• Thibaud Mathis, MD

  Hospices Civils de Lyon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 9, 2019
• First Posted: May 15, 2019
• Study Start: July 1, 2016
• Primary Completion: September 30, 2017
• Study Completion: September 30, 2017
• Last Updated: May 15, 2019

Record last verified: 2019-05