Cardiorespiratory Responses to Treadmill Running at Different Slopes

NCT03946215 | Completed

• 1 other identifier: 7038
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is: i) to determine if maximal oxygen uptake in downhill running is significantly different versus flat or uphill running, and ii) to compare cardiorespiratory and muscle fatigue responses to uphill vs flat and downhill running at similar running velocity and similar metabolic power. The investigators hypothesized that maximal oxygen uptake will be lower in downhill running. The investigators also anticipate attenuated cardiorespiratory and muscle fatigue responses to downhill running when compared to flat or uphill running performed at similar velocity but not when the comparison is done at similar metabolic power.

Conditions

Cardiorespiratory Responses; Well-trained Athletes

Outcome Measures

Primary Outcomes (1)

• Peak oxygen

  The peak oxygen uptake will be collected during downhill, flat and uphill running

  15 minutes

Study Arms (1)

well-trained athletes

EXPERIMENTAL

A cardiorespiratory stress test

Other: Each participant will perform:

Interventions

Each participant will perform: OTHER

Part 1: Maximal incremental tests will require running at fixed slopes (+15%, 0% -15%) for stages (2min duration) of increasing velocities (0.5, 1 and 1.5 km/h) Part two: submaximal running tests will require running at constant velocity (80% VO2max uphill; 80%VO2max downhill and downhill at similar velocity as uphill)

well-trained athletes

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• to be a well-trained runner with a VO2max \> à 55 ml/kg/min
• nonsmoker or stopped smoking for 5 years
• BMI \< 25
• affiliation to the social health insurance scheme
• signing an informed consent form.

You may not qualify if:

• impossibility to give the subject enlightened information (subject in emergency situation, difficulties in understanding the study, ...);
• subject under the protection of justice
• subject under guardianship or curatorship
• contraindication to the practice of physical and sport activities
• lower limbs musculotendinous or articular problems
• respiratory, cardiovascular or metabolic pathology
• drug treatment in progress and impossibility to stop it within 7 days before the beginning of the study

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Les Hôpitaux Universitaires de Strasbourg

Strasbourg, 67091, France

Location

Related Publications (1)

• Lemire M, Hureau TJ, Remetter R, Geny B, Kouassi BYL, Lonsdorfer E, Isner-Horobeti ME, Favret F, Dufour SP. Trail Runners Cannot Reach V O2max during a Maximal Incremental Downhill Test. Med Sci Sports Exerc. 2020 May;52(5):1135-1143. doi: 10.1249/MSS.0000000000002240.

  PMID: 31815832 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 31, 2018
• First Posted: May 10, 2019
• Study Start: September 1, 2018
• Primary Completion: December 17, 2018
• Study Completion: December 17, 2018
• Last Updated: October 1, 2025

Record last verified: 2025-09

Locations

FR (1)