EEG Changes During Induction of Propofol Anesthesia
PropoStatus
Assessment of EEG Changes During Induction of Propofol Anesthesia Using Wireless Measurement Devices
1 other identifier
observational
45
1 country
1
Brief Summary
PropoStatus is a prospective observational study investigating the EEG changes seen in neurologically healthy patients during induction of general anesthesia with propofol.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 25, 2018
CompletedFirst Submitted
Initial submission to the registry
May 7, 2019
CompletedFirst Posted
Study publicly available on registry
May 9, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 28, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
March 28, 2024
CompletedMay 5, 2026
December 1, 2024
5.4 years
May 7, 2019
April 28, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
EEG slow-wave activity
EEG slow-wave activity is defined by the low-frequency (\<1 Hz) signal power. The study investigates the topographic distribution of the activity as well as the coupling of the activity between the electrodes. The relation of slow-wave activity and loss of consciousness will be investigated as well.
Induction of anesthesia (approx. 10-30 min)
Secondary Outcomes (1)
EEG activity on other frequency bands
Induction of anesthesia (approx. 10-30 min)
Eligibility Criteria
Neurologically healthy individuals coming to hospital for elective surgery with general anesthesia
You may qualify if:
- ASA 1-2 (no neurological or cardiovascular diseases)
You may not qualify if:
- BMI \> 30
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Oululead
- South Carelia Central Hospitalcollaborator
- Cerenion Oycollaborator
Study Sites (1)
South Karelia Central Hospital
Lappeenranta, 53130, Finland
Related Publications (3)
Kortelainen J, Vayrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppanen T, Ala-Kokko T. Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury. Anesthesiology. 2017 Jan;126(1):94-103. doi: 10.1097/ALN.0000000000001385.
PMID: 27749312BACKGROUNDKortelainen J, Vayrynen E, Juuso I, Laurila J, Koskenkari J, Ala-Kokko T. Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest. J Clin Monit Comput. 2020 Feb;34(1):105-110. doi: 10.1007/s10877-019-00282-3. Epub 2019 Feb 20.
PMID: 30788811BACKGROUNDKortelainen J, Ala-Kokko T, Tiainen M, Strbian D, Rantanen K, Laurila J, Koskenkari J, Kallio M, Toppila J, Vayrynen E, Skrifvars MB, Hastbacka J. Early recovery of frontal EEG slow wave activity during propofol sedation predicts outcome after cardiac arrest. Resuscitation. 2021 Aug;165:170-176. doi: 10.1016/j.resuscitation.2021.05.032. Epub 2021 Jun 7.
PMID: 34111496BACKGROUND
Study Officials
- PRINCIPAL INVESTIGATOR
Jukka Kortelainen, MD, PhD
University of Oulu
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 7, 2019
First Posted
May 9, 2019
Study Start
October 25, 2018
Primary Completion
March 28, 2024
Study Completion
March 28, 2024
Last Updated
May 5, 2026
Record last verified: 2024-12
Data Sharing
- IPD Sharing
- Will not share