Development and Initial Tests of Reward Re-Training: A Novel Treatment For Reward Dysfunction

NCT03942874 | Completed

• 1 other identifier: Project Recharge
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test a novel treatment for binge eating that will be compared to a waitlist control group. The investigators are seeking to target factors that might influence binge eating by increasing reward in non-food life domains. The treatment is weekly for 10 weeks and will take place at Drexel University in Philadelphia.

Conditions

Binge Eating; Binge-Eating Disorder; Bulimia Nervosa

Keywords

reward; reward dysfunction; group treatment; binge eating

Outcome Measures

Primary Outcomes (2)

• Feedback Questionnaire (FQ)

  The feedback questionnaire asks qualitative questions about the quality of and satisfaction with the treatment. The feedback questionnaire does not report either subscale scores or a total score. The FQ will be used to obtain qualitative acceptability ratings.

  Assessed at mid- and post- treatment sessions (3 months)

• Binge frequency assessed by the Eating Disorder Examination

  Frequency (number of days and number of instances) of binge eating behaviors over the past 28 days assessed by the Eating Disorder Examination

  Change from baseline assessment (before beginning treatment) to post-treatment assessment (10 weeks after baseline assessment)

Secondary Outcomes (1)

• Reward responsivity to natural (nonfood) reward- Reward Probability Index (RPI)

  Change from baseline assessment (before beginning treatment) to post-treatment assessment (10 weeks after baseline assessment)

Study Arms (2)

Treatment

EXPERIMENTAL

Participants will complete baseline sessions and then complete treatment right away.

Behavioral: Group Reward Retraining

Waitlist Control

EXPERIMENTAL

Participants will complete a baseline session and then wait for 10 weeks before starting treatment.

Behavioral: Group Reward Retraining

Interventions

Group Reward Retraining BEHAVIORAL

Adapted behavioral activation group treatment for binge eating with values and cognitive skills integrated

Also known as: behavioral activation

Treatment; Waitlist Control

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• clinically significant binge eating

You may not qualify if:

• non-removable metal object in body
• non-removable hair extensions or wig
• tattoo above shoulders
• significant amounts of metal fillings in mouth
• BMI below 18.5
• BMI above 40
• Currently experiencing severe psychopathology that would limit their ability to engage in study (e.g. suicidality, substance use disorder, psychotic disorder)
• Are unable to fluently speak, write and read English

Sponsors & Collaborators

• Drexel University: lead

Study Sites (1)

Drexel WELL Center

Philadelphia, Pennsylvania, 19104, United States

Location

Related Publications (1)

• Juarascio AS, Presseller EK, Wilkinson ML, Kelkar A, Srivastava P, Chen JY, Dengler J, Manasse SM, Medaglia J. Correcting the reward imbalance in binge eating: A pilot randomized trial of reward re-training treatment. Appetite. 2022 Sep 1;176:106103. doi: 10.1016/j.appet.2022.106103. Epub 2022 Jun 1.

  PMID: 35662619 DERIVED

MeSH Terms

Conditions

Bulimia; Binge-Eating Disorder; Bulimia Nervosa

Condition Hierarchy (Ancestors)

Hyperphagia; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Feeding and Eating Disorders; Mental Disorders

Study Officials

• Adrienne Juarascio, PhD

  Drexel University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 25, 2019
• First Posted: May 8, 2019
• Study Start: April 24, 2019
• Primary Completion: September 30, 2019
• Study Completion: September 30, 2019
• Last Updated: September 22, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)