Assessment of Natural Killer Cells in Unexplained Recurrent Pregnancy Loss

NCT03941470 | Unknown

• 1 other identifier: 17200339
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

To assess natural killer cells frequency and activation in cases of unexplained recurrent abortion in comparison to fertile cases

• 2\. . To study the expression of stimulatory receptors of natural killer cell.
• 3-To study the expression of inhibitory receptors of natural killer cell.

Conditions

Female; Recurrent Miscarriage; Unexplained Pregnancy Loss

Keywords

NK ;natural killer cells

Outcome Measures

Primary Outcomes (1)

• asses the number of Natural killer cells

  flowcytometry

  15 month

Study Arms (2)

unexplained recurrent pregnancy loss

peripheral blood sample examined by flowcytometry

control fertile multipara

peripheral blood sample examined by flowcytometry

Eligibility Criteria

• Age: Up to 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

We will recruit patients from outpatient clinics from Assuit University Hospital,Women fulfilling eligibility criteria will be included after careful gynecologycal examination,Those who consent to participate will be referred to the lab for investigation.

You may qualify if:

• Age less than 40 years. 2.History of two or more spontaneous miscarriages .

You may not qualify if:

• \. Age more than 35 years. 2. Women with elevated level of TSH above (2.5 mIU/ml) or prolactin above( 19.5 ng/mL)and uncontrolled DM.
• \. Women with autoimmune disorder (antiphospholipid antibody syndrome)with LA1/LA2 ratio more than( 1.2).
• Women receiving oral contraceptive pills.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Yossra Mahmoud Mohammed

Asyut, 088, Egypt

Location

Related Publications (1)

• Fukui A, Kamoi M, Funamizu A, Fuchinoue K, Chiba H, Yokota M, Fukuhara R, Mizunuma H. NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis. Reprod Med Biol. 2015 Apr 11;14(4):151-157. doi: 10.1007/s12522-015-0207-7. eCollection 2015 Oct.

  PMID: 29259412 RESULT

MeSH Terms

Conditions

Abortion, Habitual

Condition Hierarchy (Ancestors)

Abortion, Spontaneous; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• assiut university

  Assiut University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assesment of Natu

Study Record Dates

• First Submitted: May 6, 2019
• First Posted: May 8, 2019
• Study Start: April 30, 2019
• Primary Completion: December 1, 2019
• Study Completion: July 20, 2020
• Last Updated: May 8, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)