Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients
TregCMRRS
Combination With Regulatory T Cell Levels and Cardiac Magnetic Resonance Imaging (CMR) to Assess the Severity and Prognosis of Reperfusion Injury After Primary PCI in STEMI Patients (TregCMRRS)
1 other identifier
observational
250
1 country
1
Brief Summary
This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2019
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 3, 2019
CompletedFirst Posted
Study publicly available on registry
May 6, 2019
CompletedStudy Start
First participant enrolled
July 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2021
CompletedJune 26, 2019
June 1, 2019
2.2 years
May 3, 2019
June 25, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
MACE (major adverse cardiovascular events)
nonfatal or fatal myocardial infarction, revascularization, cardiac death, nonfatal or fatal stroke, all cause of death
12 months
Secondary Outcomes (1)
adverse cardiac remodeling
6 months
Study Arms (1)
Participates
Interventions
This is an observational study. Exposure: Different Treg levels and CMR results.
Eligibility Criteria
Patients admitted to Beijing Friendship Hospital,Capital Medical University with a confirmed STEMI diagnosis undergoing primary percutaneous coronary intervention
You may qualify if:
- Confirmed STEMI diagnosis
- Undergoing primary percutaneous coronary intervention (presenting \<12 hours after symptom onset)
- Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckle tracking imaging echocardiogram (STE) examinations
- Patients agreed and provided informed consent
You may not qualify if:
- Previous myocardial infarction or revascularization (PCI or CABG)
- Congestive heart failure with LVEF\<40%
- Atrial fibrillation
- Renal insufficiency (GFR \< 30 ml/min/1.73m\^2)
- Acute infectious diseases within nearly 3 months
- Rheumatic immune system diseases
- Malignant tumors
- Claustrophobia
- Contraindicated to CMR
- Patients do not agree to be included in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
Related Publications (1)
Zhang Y, Gao H, Liu L, Li S, Hua B, Lan D, He Y, Li J, Chen H, Li W, Li H. Regulatory T Cell as Predictor of Intramyocardial Hemorrhage in STEMI Patients after Primary PCI. Rev Cardiovasc Med. 2023 Jul 14;24(7):205. doi: 10.31083/j.rcm2407205. eCollection 2023 Jul.
PMID: 39077002DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof.
Study Record Dates
First Submitted
May 3, 2019
First Posted
May 6, 2019
Study Start
July 1, 2019
Primary Completion
August 31, 2021
Study Completion
August 31, 2021
Last Updated
June 26, 2019
Record last verified: 2019-06