NCT03938233

Brief Summary

Type 2 diabetes is amongst the foremost challenges facing policy makers in Thailand, accounting for considerable death, disability and healthcare expenditure. Under Thailand's strong primary health system, medical management of diabetes is widely available. However, control of blood glucose and other cardiovascular disease risk factors, and regular screening for early detection of complications remain low due to a lack of services for education and counselling to support behavioural changes necessary for good self-management of the condition. A substantial literature documents the effectiveness of Diabetes Self-Management Education (DSME) programs for improving diabetes outcomes, although little high-quality data are available in Thailand, and traditional delivery models (health-professional led one-to-one or small-group sessions) are unlikely to be scalable in Thailand given current human resource and budgetary constraints. Thus, a low-cost DSME program will be developed with a scalable delivery model for roll-out within the Thai primary care system. The intervention will be based on behaviour-change and social support theories, delivered in monthly group meetings by lay health workers or nurses, and aided by a suite of short films to introduce key topics and stimulate discussion. 21 primary care units will be randomised to offer to those with diabetes diagnosed within the first three years. DSME will be delivered by lay health workers, nurses (for comparative effectiveness), or usual care. After 12 months, glycaemic control and cardiovascular risk scores will be compared between the three arms. Cost-effectiveness will be assessed, also process and policy evaluations to produce best-buy recommendations for the Thai Ministry of Public Health.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
693

participants targeted

Target at P75+ for not_applicable diabetes-mellitus-type-2

Timeline
Completed

Started Mar 2020

Longer than P75 for not_applicable diabetes-mellitus-type-2

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 24, 2019

Completed
12 days until next milestone

First Posted

Study publicly available on registry

May 6, 2019

Completed
10 months until next milestone

Study Start

First participant enrolled

March 1, 2020

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2022

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2023

Completed
Last Updated

January 18, 2020

Status Verified

February 1, 2019

Enrollment Period

2.5 years

First QC Date

April 24, 2019

Last Update Submit

January 13, 2020

Conditions

Keywords

DiabetesSelf-managementStructured EducationThailandPeer Led

Outcome Measures

Primary Outcomes (2)

  • Hemoglobin A1c levels (HbA1c)

    HbA1c will measures the average blood glucose (sugar) levels months

    12 months

  • Total cardiovascular risk

    The cardiovascular risk will be estimated by Systemic Coronary Risk Evaluation. (SCORE) model. This is a range from 120 to 180 measuring systolic blood pressure (mmHq).

    12 months

Secondary Outcomes (6)

  • EQ-5D

    12 months

  • Hospital Anxiety and Depression scale (HADS)

    12 months

  • Perceived Stress Questionnaire (PSQ)

    12 months

  • Summary of Diabetes Self-Care Activities Assessment (SDSCA)

    12 months

  • International Physical Activity Questionnaire

    12 months

  • +1 more secondary outcomes

Other Outcomes (1)

  • Smoking

    12 months

Study Arms (3)

DSME program delivered by community health volunteers

ACTIVE COMPARATOR

Randomisation will happen in 21 primary care units to offer DSME delivered by lay health workers to those newly diagnosed with diabetes and those having difficulties with self-managing their diabetes.

Behavioral: A low-cost DSME program and scalable delivery model for roll-out within the Thai primary care system

DSME program delivered by nurses

ACTIVE COMPARATOR

Randomisation will happen in 21 primary care units to offer DSME delivered by nurses (for comparative effectiveness) to those newly diagnosed with diabetes and those having difficulties with self-managing their diabetes.

Behavioral: A low-cost DSME program and scalable delivery model for roll-out within the Thai primary care system

Usual care(no DSME program)

NO INTERVENTION

Randomisation will happen in 21 primary care units where no DSME will be offered to those newly diagnosed with diabetes and/or those having difficulties with self-managing their diabetes.These patients will continue with usual care and will be assessed as the control group.

Interventions

The intervention will be based on behaviour-change and social support theories, delivered in monthly group meetings by lay health workers or nurses, and aided by a suite of short films to introduce key topics and stimulate discussion.

DSME program delivered by community health volunteersDSME program delivered by nurses

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • People aged over 18 years with a new referral for type-2 diabetes management at the 15 hospitals
  • People aged over 18 years with difficulties managing type-2 diabetes up to three years of diagnosis at the 15 hospitals
  • Willingness to attend educational group meetings
  • Available for 12-month follow-up

You may not qualify if:

  • Advanced diabetes complications such as receiving dialysis, registered blind, above ankle amputations.
  • Co-morbid learning difficulties, dementia or severe mental illness
  • Lacking the capacity to consent
  • Those aged under 18 years.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Papachristou Nadal I, Aramrat C, Jiraporncharoen W, Pinyopornpanish K, Wiwatkunupakarn N, Quansri O, Rerkasem K, Srivanichakorn S, Techakehakij W, Wichit N, Pateekhum C, Birk N, Ngetich E, Khunti K, Hanson K, Kinra S, Angkurawaranon C. Process evaluation protocol of a cluster randomised trial for a scalable solution for delivery of Diabetes Self-Management Education in Thailand (DSME-T). BMJ Open. 2021 Dec 9;11(12):e056141. doi: 10.1136/bmjopen-2021-056141.

  • Angkurawaranon C, Papachristou Nadal I, Mallinson PAC, Pinyopornpanish K, Quansri O, Rerkasem K, Srivanichakorn S, Techakehakij W, Wichit N, Pateekhum C, Hashmi AH, Hanson K, Khunti K, Kinra S. Scalable solution for delivery of diabetes self-management education in Thailand (DSME-T): a cluster randomised trial study protocol. BMJ Open. 2020 Oct 5;10(10):e036963. doi: 10.1136/bmjopen-2020-036963.

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Sanjay Kinra, MD, PhD

    London School of Hygiene and Tropical Medicine

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Iliatha Papachristou Nadal, PhD, Psychol

CONTACT

Chaisiri Angkurawaranon, MD, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Model Details: Cluster randomised control trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 24, 2019

First Posted

May 6, 2019

Study Start

March 1, 2020

Primary Completion

September 1, 2022

Study Completion

March 1, 2023

Last Updated

January 18, 2020

Record last verified: 2019-02