Prognostic Value of Peak Lactate During Cardiopulmonary Bypass in Adult Cardiac Surgeries

NCT03934892 | Completed

• 1 other identifier: HualienTCGH
• Study Type: observational
• Target: 97
• Locations: 0 countries
• Sites: N/A

Brief Summary

Tissue hypoperfusion during cardiopulmonary bypass (CPB) affects cardiac surgical outcomes. Lactate, an end product of anaerobic glycolysis from oxygen deficit, is an obtainable marker of tissue hypoxia. The investigators aimed to determine the value of blood lactate level during CPB in adult cardiac surgeries in predicting outcomes. The investigators retrospectively reviewed the patients underwent cardiac surgeries with CPB from January 2015 to December 2015. The patient's characteristics, pre-operative status, surgical type, and intra-operative lactate levels were collected. The outcomes were in-hospital mortality and complications. Receiver operating characteristics (ROC) curves were used to assess the ability of peak lactate level during CPB to predict in-hospital mortality.

Conditions

Cardiopulmonary Bypass; Lactate

Outcome Measures

Primary Outcomes (1)

• in-hospital mortality

  peak lactate level during cardiopulmonary bypass predicts in-hospital mortality

  From date of inclusion until date of death from any cause during hospitalization, assessed up to one year

Study Arms (1)

lactate during CPB

check lactate levels routinely during cardiac operations with cardiopulmonary bypass, choose the peak lactate data

Diagnostic Test: serum lactate

Interventions

serum lactate DIAGNOSTIC_TEST

check lactate levels during cardiopulmonary bypass in adult cardiac operations

lactate during CPB

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

adults patients underwent cardiac surgeries with cardiopulmonary bypass from January 2015 to December 2015

You may qualify if:

• adults patients underwent cardiac surgeries with cardiopulmonary bypass from January 2015 to December 2015

You may not qualify if:

• patients with missing data from records

Sponsors & Collaborators

• Hualien Tzu Chi General Hospital: lead

Related Publications (2)

• Demers P, Elkouri S, Martineau R, Couturier A, Cartier R. Outcome with high blood lactate levels during cardiopulmonary bypass in adult cardiac operation. Ann Thorac Surg. 2000 Dec;70(6):2082-6. doi: 10.1016/s0003-4975(00)02160-3.

  PMID: 11156124 RESULT

• O'Connor E, Fraser JF. The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery. Anaesth Intensive Care. 2012 Jul;40(4):598-603. doi: 10.1177/0310057X1204000404.

  PMID: 22813486 RESULT

Study Officials

• Yi-tso Cheng, MD

  Hualien Tzu Chi General Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: April 24, 2019
• First Posted: May 2, 2019
• Study Start: January 1, 2015
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: May 2, 2019

Record last verified: 2019-04