The Visual Scanning Test: a Neuropsychological Tool to Assess Extrapersonal Visual Unilateral Spatial Neglect

NCT03931798 | Completed

• 1 other identifier: IRCCSdongnocchi
• Study Type: interventional
• Target: 86
• Locations: 0 countries
• Sites: N/A

Brief Summary

Presentation and standardization on a normative sample of a new neuropsychological tool to provide a quantitative assessment of visual unilateral spatial neglect in the extrapersonal portion of space.

Conditions

Spatial Neglect

Keywords

Unilateral spatial neglect; Extrapersonal space; Neuropsychology

Outcome Measures

Primary Outcomes (1)

• Scores of clinical indexes due to the accuracy and the reaction times

  From the obtained data it was possible to get some informative indexes regarding the reaction times, the accuracy and the implicit learning of the progressive shift to the left of the target and the possible presence of asymmetry in the visual exploration.

  Clinical indexes were obtained after completing th edata collecyion, which lasted two years

Study Arms (1)

Treatment

EXPERIMENTAL

Healthy participants were administered the Visual Scanning Test

Diagnostic Test: Visual Scanning Test

Interventions

Visual Scanning Test DIAGNOSTIC_TEST

The Visual Scanning Test (VST) involved a visual search for a target between similar visual distractors, projected in the far space, so as to simulate the search within a visual field. It is overall composed by four trials, each trial contained 20 cases and made up by 20 stimuli. On about the 80% of cases, the test provided the presence of target in the left, center or in right hemispace. In the remaining 20% of cases, the test provided the presence of a catch trial (absence of the target), to assess the presence of frontal disturbances or malingering. The test is constructed according to an increasing attentional load for the target on the left-hemispace. Participants, sitting in front a blank wall, were required to actively and free explore the projected visual field to search for the visual target, naming its identification (saying YES or NO). During the task, the examiner annotated the reaction times and the errors.

Treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- healthy subjects of full age.

You may not qualify if:

• past or present neurological diseases;
• past or present psychiatric diseases;
• presence of visual disturbances.

Sponsors & Collaborators

• Fondazione Don Carlo Gnocchi Onlus: lead
• Rehabilitation Istitute Santa Maria Bambina: collaborator
• Clinical Center Agoretis: collaborator

Related Publications (46)

• Priftis K, Passarini L, Pilosio C, Meneghello F, Pitteri M. Visual Scanning Training, Limb Activation Treatment, and Prism Adaptation for Rehabilitating Left Neglect: Who is the Winner? Front Hum Neurosci. 2013 Jul 8;7:360. doi: 10.3389/fnhum.2013.00360. eCollection 2013.

  PMID: 23847520 BACKGROUND

• Vallar G, Calzolari E. Unilateral spatial neglect after posterior parietal damage. Handb Clin Neurol. 2018;151:287-312. doi: 10.1016/B978-0-444-63622-5.00014-0.

  PMID: 29519463 BACKGROUND

• Vallar, G., & Bolognini, N. (2014). Unilateral spatial neglect. In A. C. Nobre & S. Kastner (Eds.), Oxford library of psychology. The Oxford handbook of attention (pp. 972-1027). New York, NY, US: Oxford University Press..

  BACKGROUND

• Bisiach E, Vallar G, Perani D, Papagno C, Berti A. Unawareness of disease following lesions of the right hemisphere: anosognosia for hemiplegia and anosognosia for hemianopia. Neuropsychologia. 1986;24(4):471-82. doi: 10.1016/0028-3932(86)90092-8.

  PMID: 3774133 BACKGROUND

• Ten Brink AF, Verwer JH, Biesbroek JM, Visser-Meily JMA, Nijboer TCW. Differences between left- and right-sided neglect revisited: A large cohort study across multiple domains. J Clin Exp Neuropsychol. 2017 Sep;39(7):707-723. doi: 10.1080/13803395.2016.1262333. Epub 2016 Dec 12.

  PMID: 27951747 BACKGROUND

• Ten Brink AF, Biesbroek JM, Oort Q, Visser-Meily JMA, Nijboer TCW. Peripersonal and extrapersonal visuospatial neglect in different frames of reference: A brain lesion-symptom mapping study. Behav Brain Res. 2019 Jan 1;356:504-515. doi: 10.1016/j.bbr.2018.06.010. Epub 2018 Jun 22.

  PMID: 29940260 BACKGROUND

• Bowen A, McKenna K, Tallis RC. Reasons for variability in the reported rate of occurrence of unilateral spatial neglect after stroke. Stroke. 1999 Jun;30(6):1196-202. doi: 10.1161/01.str.30.6.1196.

  PMID: 10356099 BACKGROUND

• Denes G, Semenza C, Stoppa E, Lis A. Unilateral spatial neglect and recovery from hemiplegia: a follow-up study. Brain. 1982 Sep;105 (Pt 3):543-52. doi: 10.1093/brain/105.3.543.

  PMID: 7104665 BACKGROUND

• Machner B, Konemund I, von der Gablentz J, Bays PM, Sprenger A. The ipsilesional attention bias in right-hemisphere stroke patients as revealed by a realistic visual search task: Neuroanatomical correlates and functional relevance. Neuropsychology. 2018 Oct;32(7):850-865. doi: 10.1037/neu0000493.

  PMID: 30321035 BACKGROUND

• Gainotti G. The role of automatic orienting of attention towards ipsilesional stimuli in non-visual (tactile and auditory) neglect: a critical review. Cortex. 2010 Feb;46(2):150-60. doi: 10.1016/j.cortex.2009.04.006. Epub 2009 May 14.

  PMID: 19501350 BACKGROUND

• Appelros P, Nydevik I, Karlsson GM, Thorwalls A, Seiger A. Assessing unilateral neglect: shortcomings of standard test methods. Disabil Rehabil. 2003 May 6;25(9):473-9. doi: 10.1080/0963828031000071714.

  PMID: 12745942 BACKGROUND

• Buxbaum LJ, Ferraro MK, Veramonti T, Farne A, Whyte J, Ladavas E, Frassinetti F, Coslett HB. Hemispatial neglect: Subtypes, neuroanatomy, and disability. Neurology. 2004 Mar 9;62(5):749-56. doi: 10.1212/01.wnl.0000113730.73031.f4.

  PMID: 15007125 BACKGROUND

• Danckert J, Ferber S. Revisiting unilateral neglect. Neuropsychologia. 2006;44(6):987-1006. doi: 10.1016/j.neuropsychologia.2005.09.004. Epub 2005 Nov 21.

  PMID: 16300805 BACKGROUND

• Berti A, Smania N, Rabuffetti M, Ferrarin M, Spinazzola L, D'Amico A, Ongaro E, Allport A. Coding of far and near space during walking in neglect patients. Neuropsychology. 2002 Jul;16(3):390-9. doi: 10.1037//0894-4105.16.3.390.

  PMID: 12146686 BACKGROUND

• Lindell AB, Jalas MJ, Tenovuo O, Brunila T, Voeten MJ, Hamalainen H. Clinical assessment of hemispatial neglect: evaluation of different measures and dimensions. Clin Neuropsychol. 2007 May;21(3):479-97. doi: 10.1080/13854040600630061.

  PMID: 17455032 BACKGROUND

• Pedroli E, Serino S, Cipresso P, Pallavicini F, Riva G. Assessment and rehabilitation of neglect using virtual reality: a systematic review. Front Behav Neurosci. 2015 Aug 25;9:226. doi: 10.3389/fnbeh.2015.00226. eCollection 2015.

  PMID: 26379519 BACKGROUND

• Parton A, Malhotra P, Husain M. Hemispatial neglect. J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):13-21.

  PMID: 14707298 BACKGROUND

• Coslett HB. Apraxia, Neglect, and Agnosia. Continuum (Minneap Minn). 2018 Jun;24(3, BEHAVIORAL NEUROLOGY AND PSYCHIATRY):768-782. doi: 10.1212/CON.0000000000000606.

  PMID: 29851877 BACKGROUND

• Butler BC, Eskes GA, Vandorpe RA. Gradients of detection in neglect: comparison of peripersonal and extrapersonal space. Neuropsychologia. 2004;42(3):346-58. doi: 10.1016/j.neuropsychologia.2003.08.008.

  PMID: 14670573 BACKGROUND

• Cipresso P, Pedroli E, Serino S, Semonella M, Tuena C, Colombo D, Pallavicini F, Riva G. Assessment of Unilateral Spatial Neglect Using a Free Mobile Application for Italian Clinicians. Front Psychol. 2018 Nov 22;9:2241. doi: 10.3389/fpsyg.2018.02241. eCollection 2018.

  PMID: 30524341 BACKGROUND

• Cocchini, G., Beschin, N., &Jehkonen, M. (2001). The Fluff Test: A simple task to assess body representation neglect. Neuropsychological Rehabilitation, 11(1), 17-31.

  BACKGROUND

• Azouvi P, Olivier S, de Montety G, Samuel C, Louis-Dreyfus A, Tesio L. Behavioral assessment of unilateral neglect: study of the psychometric properties of the Catherine Bergego Scale. Arch Phys Med Rehabil. 2003 Jan;84(1):51-7. doi: 10.1053/apmr.2003.50062.

  PMID: 12589620 BACKGROUND

• Rengachary J, d'Avossa G, Sapir A, Shulman GL, Corbetta M. Is the posner reaction time test more accurate than clinical tests in detecting left neglect in acute and chronic stroke? Arch Phys Med Rehabil. 2009 Dec;90(12):2081-8. doi: 10.1016/j.apmr.2009.07.014.

  PMID: 19969172 BACKGROUND

• Cunningham LJ, O'Rourke K, Finlay C, Gallagher M. A preliminary investigation into the psychometric properties of the Dublin Extrapersonal Neglect Assessment (DENA): A novel screening tool for extrapersonal neglect. Neuropsychol Rehabil. 2017 Apr;27(3):349-368. doi: 10.1080/09602011.2015.1084334. Epub 2015 Sep 30.

  PMID: 26421958 BACKGROUND

• Bonato M. Neglect and extinction depend greatly on task demands: a review. Front Hum Neurosci. 2012 Jul 17;6:195. doi: 10.3389/fnhum.2012.00195. eCollection 2012.

  PMID: 22822394 BACKGROUND

• Barrett AM, Buxbaum LJ, Coslett HB, Edwards E, Heilman KM, Hillis AE, Milberg WP, Robertson IH. Cognitive rehabilitation interventions for neglect and related disorders: moving from bench to bedside in stroke patients. J Cogn Neurosci. 2006 Jul;18(7):1223-36. doi: 10.1162/jocn.2006.18.7.1223.

  PMID: 16839294 BACKGROUND

• Hasegawa C, Hirono N, Yamadori A. Discrepancy in unilateral spatial neglect between daily living and neuropsychological test situations: a single case study. Neurocase. 2011 Dec;17(6):518-26. doi: 10.1080/13554794.2010.547506. Epub 2011 Jun 27.

  PMID: 21707261 BACKGROUND

• Bonato M, Priftis K, Marenzi R, Umilta C, Zorzi M. Deficits of contralesional awareness: a case study on what paper-and-pencil tests neglect. Neuropsychology. 2012 Jan;26(1):20-36. doi: 10.1037/a0025306. Epub 2011 Sep 5.

  PMID: 21895377 BACKGROUND

• Bonato M, Deouell LY. Hemispatial neglect: computer-based testing allows more sensitive quantification of attentional disorders and recovery and might lead to better evaluation of rehabilitation. Front Hum Neurosci. 2013 May 1;7:162. doi: 10.3389/fnhum.2013.00162. eCollection 2013. No abstract available.

  PMID: 23641207 BACKGROUND

• Priftis K, Bonato M, Zorzi M, Umilta C. Spatial and non-spatial aspects of neglect. Front Hum Neurosci. 2013 Feb 5;7:25. doi: 10.3389/fnhum.2013.00025. eCollection 2013. No abstract available.

  PMID: 23386825 BACKGROUND

• Kerkhoff G, Schenk T. Rehabilitation of neglect: an update. Neuropsychologia. 2012 May;50(6):1072-9. doi: 10.1016/j.neuropsychologia.2012.01.024. Epub 2012 Jan 28.

  PMID: 22306520 BACKGROUND

• Capitani, E. (1997). Normative data and neuropsychological assessment. Common problems in clinical practice and research. Neuropsychological Rehabilitation, 7(4), 295-310.

  BACKGROUND

• Capitani E, Laiacona M. Composite neuropsychological batteries and demographic correction: standardization based on equivalent scores, with a review of published data. The Italian Group for the Neuropsychological Study of Ageing. J Clin Exp Neuropsychol. 1997 Dec;19(6):795-809. doi: 10.1080/01688639708403761.

  PMID: 9524875 BACKGROUND

• Wilks, S. S. (1941). Determination of sample sizes for setting tolerance limits. The Annals of Mathematical Statistics, 12(1), 91-96.

  BACKGROUND

• Capitani E, Laiacona M. Outer and inner tolerance limits: their usefulness for the construction of norms and the standardization of neuropsychological tests. Clin Neuropsychol. 2017 Aug-Oct;31(6-7):1219-1230. doi: 10.1080/13854046.2017.1334830. Epub 2017 Jun 9.

  PMID: 28598726 BACKGROUND

• Bartolomeo P, Chokron S. Left unilateral neglect or right hyperattention? Neurology. 1999 Dec 10;53(9):2023-7. doi: 10.1212/wnl.53.9.2023.

  PMID: 10599775 BACKGROUND

• Bartolomeo, P. (2014). The attention systems of the human brain. In Attention Disorders After Right Brain Damage (pp. 1-19). Springer, London.

  BACKGROUND

• Bourgeois A, Chica AB, Migliaccio R, Thiebaut de Schotten M, Bartolomeo P. Cortical control of inhibition of return: evidence from patients with inferior parietal damage and visual neglect. Neuropsychologia. 2012 Apr;50(5):800-9. doi: 10.1016/j.neuropsychologia.2012.01.014. Epub 2012 Jan 20.

  PMID: 22285795 BACKGROUND

• Posner MI, Walker JA, Friedrich FJ, Rafal RD. Effects of parietal injury on covert orienting of attention. J Neurosci. 1984 Jul;4(7):1863-74. doi: 10.1523/JNEUROSCI.04-07-01863.1984.

  PMID: 6737043 RESULT

• Lupianez J, Klein RM, Bartolomeo P. Inhibition of return: Twenty years after. Cogn Neuropsychol. 2006 Oct 1;23(7):1003-14. doi: 10.1080/02643290600588095.

  PMID: 21049364 RESULT

• Hartmann M, Sommer NR, Diana L, Muri RM, Eberhard-Moscicka AK. Further to the right: Viewing distance modulates attentional asymmetries ('pseudoneglect') during visual exploration. Brain Cogn. 2019 Feb;129:40-48. doi: 10.1016/j.bandc.2018.11.008. Epub 2018 Nov 22.

  PMID: 30471991 RESULT

• Gamberini L, Seraglia B, Priftis K. Processing of peripersonal and extrapersonal space using tools: evidence from visual line bisection in real and virtual environments. Neuropsychologia. 2008 Apr;46(5):1298-304. doi: 10.1016/j.neuropsychologia.2007.12.016. Epub 2007 Dec 27.

  PMID: 18242649 RESULT

• Bjoertomt O, Cowey A, Walsh V. Spatial neglect in near and far space investigated by repetitive transcranial magnetic stimulation. Brain. 2002 Sep;125(Pt 9):2012-22. doi: 10.1093/brain/awf211.

  PMID: 12183347 RESULT

• Heilman KM, Van Den Abell T. Right hemisphere dominance for attention: the mechanism underlying hemispheric asymmetries of inattention (neglect). Neurology. 1980 Mar;30(3):327-30. doi: 10.1212/wnl.30.3.327.

  PMID: 7189037 RESULT

• Mesulam MM. Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1325-46. doi: 10.1098/rstb.1999.0482.

  PMID: 10466154 RESULT

• Borsotti M, Mosca IE, Di Lauro F, Pancani S, Bracali C, Dore T, Macchi C, Cecchi F; IRCCS Don Gnocchi Stroke Group. The Visual Scanning Test: a newly developed neuropsychological tool to assess and target rehabilitation of extrapersonal visual unilateral spatial neglect. Neurol Sci. 2020 May;41(5):1145-1152. doi: 10.1007/s10072-019-04218-2. Epub 2020 Jan 2.

  PMID: 31897939 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: April 26, 2019
• First Posted: April 30, 2019
• Study Start: November 2, 2015
• Primary Completion: January 15, 2017
• Study Completion: January 9, 2018
• Last Updated: May 7, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share