Long-term Outcomes, Recurrence Rates, and Treatment Needs in Polypoidal Choroidal Vasculopathy (PCV)

NCT03929731 | Completed

• 1 other identifier: R1597/96/2018
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 3

Brief Summary

To determine long-term outcomes, recurrence rates, and treatment needs in Polypoidal Choroidal Vasculopathy (PCV). Specifically, to describe the long-term outcomes, recurrence rates and treatment patterns PCV patients 5 years after first presentation. This study will also evaluate whether polyp closure within the first 12 months of therapy is associated with better long-term visual outcome and will also determine the risk of disease development in the fellow eye

Conditions

Polypoidal Choroidal Vasculopathy

Outcome Measures

Primary Outcomes (1)

• Long term prognostication

  Long term recurrence rates, correlated baseline characteristics and initial treatment strategies correlated to long term outcomes

  within 72 months

Study Arms (1)

Polypoidal Choroidal Vasculopathy RCT

Participants will have completed the previous PCV RCTs: EVEREST II, PLANET and PCV T\&E studies

Diagnostic Test: Indocyanine Green Angiography

Interventions

Indocyanine Green Angiography DIAGNOSTIC_TEST

Intravenous injection of dye-indocyanine green

Also known as: Optical Coherence Tomography-Angiography, Fundus photography, Fundus fluorescein, Optical Coherence Tomography

Polypoidal Choroidal Vasculopathy RCT

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will have completed the previous PCV RCTs: EVEREST II, PLANET and PCV T\&E studies

You may qualify if:

• Participants will have completed the previous PCV RCTs: EVEREST II, PLANET and PCV T\&E studies
• Are able to give consent for this follow up study

Sponsors & Collaborators

• Singapore National Eye Centre: lead

Study Sites (3)

Singapore National Eye Centre

Singapore, Singapore, 168751, Singapore

Location

Tan Tock Seng Hospital

Singapore, Singapore, 308433, Singapore

Location

National University Hospital

Singapore, Singapore

Location

MeSH Terms

Conditions

Polypoidal Choroidal Vasculopathy

Interventions

Fluorescein Angiography; Tomography, Optical Coherence

Condition Hierarchy (Ancestors)

Choroidal Neovascularization; Choroid Diseases; Uveal Diseases; Eye Diseases; Neovascularization, Pathologic; Metaplasia; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Angiography; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Ophthalmological; Tomography, Optical; Optical Imaging; Diagnostic Imaging; Tomography; Investigative Techniques

Study Officials

• Principal Investigator

  Singapore National Eye Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 24, 2019
• First Posted: April 29, 2019
• Study Start: July 5, 2019
• Primary Completion: May 9, 2024
• Study Completion: May 9, 2024
• Last Updated: November 18, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

SG (3)