reGional Network for Acute Myocardial Infarction

NCT03928119 | Unknown DMC

• 1 other identifier: 2014B070706010
• Study Type: interventional
• Target: 7,102
• Locations: 1 country
• Sites: 8

Brief Summary

Incidence of ST-segment Elevation Myocardial Infarction (STEMI) is rising and the existing emergency medical aid system for STEMI was not enough for timely perfusion treatment. No existing research with high-quality data focuses on the characteristic of STEMI incidence and regional network construction. Aiming of Guangdong GAMI(reGional network for Acute Myocardial Infarction) project is to establish effective collaborative regional network system for STEMI patients treatment.

Conditions

Coronary Heart Disease; Acute Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction

Keywords

Acute myocardial infarction; STEMI; regional network

Outcome Measures

Primary Outcomes (1)

• Receipt of reperfusion therapy within 12 hoursInfarction patients

  The primary outcome was the proportion of patients who received symptom-to-reperfusion treatment within 12 hours.

  From 1 month before hospitalization to 24 hours after hospitalization

Secondary Outcomes (4)

• Onset-to-admission time within 12 hours

  From 1 month before hospitalization to 24 hours after hospitalization

• Door-to-balloon time within 90 minutes

  24 hours

• In-hospital clinical outcomes

  30 days

• 1-year all-cause mortality

  1 year

Study Arms (2)

Intervention group

EXPERIMENTAL

community public education, non-PCI center and emergency transfer system improvement, and inhospital green-channal optimization for PCI center.

Behavioral: public education and network construction

Control group

NO INTERVENTION

Usual care of AMI public and medical health service

Interventions

public education and network construction BEHAVIORAL

Publication education includes multiple methods of acute myocardial infarction knowledge education. Network construction includes regional connection of ST-Segment Elevation Myocardial Infarction patients transfer for percutaneous coronary intervention treatment, as well as physicians skill improvement in primary hospital.

Intervention group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All adult patients who suspected diagnosis with STEMI.

You may not qualify if:

• patients refused to undergo coronary angiography;
• patients were confirmed as non-STEMI by coronary angiography or the course of STEMI over 1 month;
• patients occurred onset STEMI during hospitalization in hospitals

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead
• Maoming People's Hospital: collaborator
• Dongguan People's Hospital: collaborator
• Southern Medical University, China: collaborator
• Guangzhou Panyu Central Hospital: collaborator
• Yangjiang People's Hospital: collaborator
• Shenzhen People's Hospital: collaborator
• Longyan First Hospital, Affiliated to Fujian Medical University: collaborator

Study Sites (8)

Longyan First Hospital Affiliated to Fujian Medical University

Longyan, Fujian, 364000, China

Location

Dongguan People's Hospital

Dongguan, Guangdong, 523000, China

Location

Shunde Hospital of Southern Medical University

Foshan, Guangdong, 528000, China

Location

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 501080, China

Location

Guangzhou Panyu Central Hospital

Guangzhou, Guangdong, 511400, China

Location

Maoming People's Hospital

Maoming, Guangdong, 525000, China

Location

Shenzhen People's Hospital

Shenzhen, Guangdong, 518000, China

Location

People's Hospital of Yangjiang

Yangjiang, Guangdong, 529500, China

Location

Related Publications (3)

• Lu J, Xuan S, Downing NS, Wu C, Li L, Krumholz HM, Jiang L. Protocol for the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project pilot. BMJ Open. 2016 Jan 4;6(1):e010200. doi: 10.1136/bmjopen-2015-010200.

  PMID: 26729395 BACKGROUND

• Yin X, He Y, Zhang J, Song F, Liu J, Sun G, Liang Y, Ye J, Hu Y, Song M, Chen C, Xu Q, Tan N, Chen J, Liu Y, Liu H, Tian M. Patient-level and system-level barriers associated with treatment delays for ST elevation myocardial infarction in China. Heart. 2020 Oct;106(19):1477-1482. doi: 10.1136/heartjnl-2020-316621. Epub 2020 Jun 24.

  PMID: 32580976 BACKGROUND

• Liu Y, Liu J, Liang Y, Ye J, Hu Y, Chen L, Dong S, Huang X, Song M, Meng R, Zheng X, He Y, Zhang J, Yin X, Chen S, Tan N, Tian M, Chen J. Effect of an integrated care model on ST-segment elevation myocardial infarction management in China: a prospective, multicentre, non-randomised controlled study. Heart. 2025 Sep 9:heartjnl-2024-324155. doi: 10.1136/heartjnl-2024-324155. Online ahead of print.

  PMID: 40930595 DERIVED

MeSH Terms

Conditions

Coronary Disease; ST Elevation Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Myocardial Infarction; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Yan Liang, MD

  Maoming People's Hospital

  PRINCIPAL INVESTIGATOR

• Jianfeng Ye, MD

  Dongguan People's Hospital

  PRINCIPAL INVESTIGATOR

• Yunzhao Hu, MD

  The first People's Hospital of Shunde, Foshan

  PRINCIPAL INVESTIGATOR

• Wenzhu Zhang, MD

  Guangzhou Panyu Central Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 21, 2019
• First Posted: April 25, 2019
• Study Start: August 1, 2015
• Primary Completion: February 28, 2020
• Study Completion: February 28, 2024
• Last Updated: June 1, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (8)