Cardio-embolic Stroke and Blood Bio-markers

NCT03927872 | Completed

• 1 other identifier: ZU-IRB# :2325/7-9-2015).
• Study Type: observational
• Target: 96
• Locations: 0 countries
• Sites: N/A

Brief Summary

Brain is a productive source of variety of enzymes and any brain injury like stroke to brain tissue could similarly result in an increase in these enzymes in cerebrospinal fluid and serum. Evaluation of these enzymes represent a simple method for the ischemic stroke subtype diagnosis and prognosis .Objective: The aim of this study was to determine the role Brain natriuretic peptide (BNP) , D-Dimer , creatine kinase- MB(CK-MB) , C reactive protein (CRP) serum levels and G/A ratio in diagnosis of CES stroke and its ability to predict short term outcome. Methods: This study was conducted on 96 patients with acute ischemic stroke, subdivided into two groups, group Ι was 48 patients with cardio-embolic stroke and group ΙΙ was 48 patients with non- cardio-embolic. all patients were subjected to assessment of serum BNP, D-Dimer and CK-MB and CRP and globulin /albumin ratio within the first 24 h of stroke .At third week ,they were assessed by mRS.

Conditions

Ischemic Stroke

Outcome Measures

Primary Outcomes (1)

• modified rankin scale

  ranging from zero(no symptoms at all) to 6 (dead).outcome was defined as good if mRS=0-2,bad (poor) if mRS=3-5 and death if mRS=6

  at the third week of stroke onset

Study Arms (2)

cardioembolic stroke

Other: blood biomarkers

non cardioembolic stroke

Other: blood biomarkers

Interventions

blood biomarkers OTHER

assessment of serum BNP, D-Dimer and CK-MB and CRP and globulin /albumin ratio stroke outcome

cardioembolic stroke; non cardioembolic stroke

Eligibility Criteria

• Age: 32 Years - 87 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

96 AIS patients divided to two groups ; group Ι : 48 patients with cardio-embolic stroke (CES) and group ΙΙ: 48 patients with cerebrovascular stroke other than cardio-embolic stroke (non CES), with first-ever acute ischemic stroke within 24 h of onset of symptoms admitted to Intensive Care and Stroke Unit

You may qualify if:

• CES and non- CES diagnosis was according to Trial of Org 10172 in Acute Stroke Treatment ﴾TOAST﴿ classification criteria.
• non -CES were selected to match patients with CES regarding age and vascular risk factors as a control group.
• Patients with National Institutes of Health Stroke Scale ﴾NIHSS ﴿ score more than 5.
• Adult patients with their ages more than 18 year.

You may not qualify if:

• Lacunar stroke and transient ischemic attacks (TIAs)
• Haemorrhagic stroke.
• Neurological causes of acute focal cerebral dysfunction such as cerebral venous sinus thrombosis , head trauma, infection, and auto immune disorders
• Heart failure
• Liver failure
• Chronic renal disease.

Sponsors & Collaborators

• Wafaa Samir: lead

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant professor of neurology

Study Record Dates

• First Submitted: April 23, 2019
• First Posted: April 25, 2019
• Study Start: October 1, 2015
• Primary Completion: October 1, 2018
• Study Completion: December 1, 2018
• Last Updated: April 30, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share