Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

NCT03927638 | Enrolling By Invitation

• 1 other identifier: 17-18-861
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Conditions

Overweight and Obesity

Outcome Measures

Primary Outcomes (7)

• Heart Rate

  Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.

  Approximately 15 minutes in each condition (sitting and standing)

• Systolic Blood Pressure (SBP)

  Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.

  Approximately 15 minutes in each condition (sitting and standing)

• Diastolic Blood Pressure (DBP)

  Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.

  Approximately 15 minutes in each condition (sitting and standing)

• Oxygen Consumption

  Oxygen consumption will be measured using indirect calorimetry.

  Approximately 15 minutes in each condition (sitting and standing)

• Carbon Dioxide Production

  Carbon Dioxide will be measured using indirect calorimetry.

  Approximately 15 minutes in each condition (sitting and standing)

• Ventilation

  Ventilation will be measured using indirect calorimetry.

  Approximately 15 minutes in each condition (sitting and standing)

• Respiratory Exchange Ration (RER)

  RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.

  Approximately 15 minutes in each condition (sitting and standing)

Secondary Outcomes (8)

• Height

  1 minute

• Weight

  1 minute

• Body Mass Index (BMI)

  1 minute

• Body Composition

  Approximately 15 minutes

• Total Peripheral Resistance (TPR)

  Approximately 15 minutes in each condition (sitting and standing)

Study Arms (2)

Normal Weight

Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.

Behavioral: sit/stand

Overweight/Obese

Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.

Behavioral: sit/stand

Interventions

sit/stand BEHAVIORAL

Subjects will be asked to both sit and stand during a single trial.

Normal Weight; Overweight/Obese

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Healthy subjects between the ages of 18 and 50 years.

You may qualify if:

• healthy adult

You may not qualify if:

• Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
• Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
• Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
• Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
• Are pregnant or trying to become pregnant.
• Are not between 18 and 50 years of age.

Sponsors & Collaborators

• Montclair State University: lead

Study Sites (1)

Montclair State University

Montclair, New Jersey, 07043, United States

Location

Related Publications (1)

• Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available.

  PMID: 31357884 BACKGROUND

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 22, 2019
• First Posted: April 25, 2019
• Study Start: November 11, 2018
• Primary Completion (Estimated): May 15, 2028
• Study Completion (Estimated): May 15, 2028
• Last Updated: January 31, 2025

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)