Pityriasis Lichenoides : Anatomo-clinical Aspects and Follow-up

NCT03920696 | Unknown

• 1 other identifier: APHP180538
• Study Type: observational
• Target: 52
• Locations: 0 countries
• Sites: N/A

Brief Summary

Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state. The current classification is confusing because it mixes semiological and chronological notions. The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population. Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed. Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.

Conditions

Pityriasis Lichenoides

Keywords

Pityriasis Lichenoides;; cutaneous lymphoma; lymphoproliferation

Outcome Measures

Primary Outcomes (1)

• To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients

  Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare.

  It will be measured within 6 months of enrollment

Secondary Outcomes (6)

• To study histological features of Pityriasis Lichenoides

  It will be measured within 6 months of enrollment

• To study molecular features of Pityriasis Lichenoides

  It will be measured within 6 months of enrollment

• To study the treatment during patients' monitoring

  It will be measured within 6 months of enrollment

• To study the duration of outbreak during patients' monitoring

  It will be measured within 6 months of enrollment

• To study the relapse during patients' monitoring

  It will be measured within 6 months of enrollment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with Pityriasis Lichenoides

You may qualify if:

• Age ≥ 18 years
• Patients with Pityriasis Lichenoides selected from histological coding OT0431, seen at Henri Mondor and with a diagnosis verified from medical records.

You may not qualify if:

• Histological coding error
• Histological records of patients in care outside Henri Mondor (cases referred for histological expertise only but not seen clinically)
• Clinical lesions incompatible with Pityriasis Lichenoides according to classically published semiological data
• Missing or insufficient medical records for data exploitation

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Related Publications (9)

• Bowers S, Warshaw EM. Pityriasis lichenoides and its subtypes. J Am Acad Dermatol. 2006 Oct;55(4):557-72; quiz 573-6. doi: 10.1016/j.jaad.2005.07.058.

  PMID: 17010734 BACKGROUND

• Zang JB, Coates SJ, Huang J, Vonderheid EC, Cohen BA. Pityriasis lichenoides: Long-term follow-up study. Pediatr Dermatol. 2018 Mar;35(2):213-219. doi: 10.1111/pde.13396. Epub 2018 Jan 9.

  PMID: 29315771 BACKGROUND

• Lalevee S, Ortonne N, Hotz C, Schlemmer F, Beldi-Ferchiou A, Delfau-Larue MH, Wolkenstein P, Chosidow O, Ingen-Housz-Oro S. Febrile ulceronecrotic Mucha Habermann disease mimicking aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma: a diagnostic challenge. Eur J Dermatol. 2018 Dec 1;28(6):834-835. doi: 10.1684/ejd.2018.3410. No abstract available.

  PMID: 30325315 BACKGROUND

• Geller L, Antonov NK, Lauren CT, Morel KD, Garzon MC. Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options. Pediatr Dermatol. 2015 Sep-Oct;32(5):579-92. doi: 10.1111/pde.12581. Epub 2015 Mar 26.

  PMID: 25816855 BACKGROUND

• Nair PS. A clinical and histopathological study of pityriasis lichenoides. Indian J Dermatol Venereol Leprol. 2007 Mar-Apr;73(2):100-2. doi: 10.4103/0378-6323.31894.

  PMID: 17456915 BACKGROUND

• Khachemoune A, Blyumin ML. Pityriasis lichenoides: pathophysiology, classification, and treatment. Am J Clin Dermatol. 2007;8(1):29-36. doi: 10.2165/00128071-200708010-00004.

  PMID: 17298104 BACKGROUND

• Zaaroura H, Sahar D, Bick T, Bergman R. Relationship Between Pityriasis Lichenoides and Mycosis Fungoides: A Clinicopathological, Immunohistochemical, and Molecular Study. Am J Dermatopathol. 2018 Jun;40(6):409-415. doi: 10.1097/DAD.0000000000001057.

  PMID: 29210716 BACKGROUND

• Sibbald C, Pope E. Systematic review of cases of cutaneous T-cell lymphoma transformation in pityriasis lichenoides and small plaque parapsoriasis. Br J Dermatol. 2016 Oct;175(4):807-9. doi: 10.1111/bjd.14605. Epub 2016 Jun 20. No abstract available.

  PMID: 27031678 BACKGROUND

• Vonderheid EC, Kadin ME, Telang GH. Commentary about papular mycosis fungoides, lymphomatoid papulosis and lymphomatoid pityriasis lichenoides: more similarities than differences. J Cutan Pathol. 2016 Apr;43(4):303-12. doi: 10.1111/cup.12653. Epub 2015 Dec 22. No abstract available.

  PMID: 26566599 BACKGROUND

MeSH Terms

Conditions

Pityriasis Lichenoides; Lymphoma, T-Cell, Cutaneous

Condition Hierarchy (Ancestors)

Lichenoid Eruptions; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Parapsoriasis; Pityriasis; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Saskia ORO, Doctor

  Assistance Publique Hôpitaux de Paris - CHU Henri Mondor - Créteil

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Saskia ORO, Doctor

CONTACT

+33 1 49 81 25 36; saskia.oro@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2019
• First Posted: April 19, 2019
• Study Start: May 1, 2019
• Primary Completion: November 1, 2019
• Study Completion: November 1, 2019
• Last Updated: April 19, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share