Whole-body Vibration Training on Functional Performance of the Elderly With Knee Osteoarthritis

NCT03918291 | Completed DMC

• 2 other identifiers: U1111-1231-3069046.08
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

The present study evaluated the effects of adding whole body vibration to squat training on the isometric quadriceps muscle strength, the plasma concentration of brain-derived neurotrophic factor at rest in elderly woman with osteoarthritis of the knee. The eligible patients were fifteen elderly women ≥ 60 years of age who had been diagnosed with osteoarthritis of the knee. The intervention consisted of uninterrupted squatting exercises for 12 weeks, a 3x/week. The exercise protocol was similar in both groups differed only in the presence of vibration.

Conditions

Osteoarthritis of Knee

Keywords

Muscle strength; Squat; Brain derived neurotrophic factor; Osteoarthritis of knee; Whole-body vibration; Elderly

Outcome Measures

Primary Outcomes (1)

• Change in isometric quadriceps muscle strength

  The maximal voluntary isometric contraction of knee extensors measured using the load cell

  24 hours before and 24 hours after a 12-week training program

Secondary Outcomes (1)

• Change in plasma concentration of neurotrophin 40/5000 Plasma neurotrophin concentration

  24 hours before and 24 hours after a 12-week training program

Study Arms (2)

Addition of whole-body vibration to squat training

EXPERIMENTAL

The addition of whole-body vibration to squat training (for 12 weeks, 3x/week). The mechanical stimulation parameters of the vibration consisted of the following: frequency of 35 to 40 Hz, amplitude of 4 mm and acceleration that ranged from 2.78 to 3.26 G

Other: Addition of whole-body vibration to squat training

Squat training

OTHER

Squatting exercises for 12 weeks, 3x/week

Other: Squat training

Interventions

Addition of whole-body vibration to squat training OTHER

Addition of whole-body vibration to squat training

Squat training OTHER

squatting exercises for 12 weeks, 3x/week

Squat training

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• females older than 65 years of age
• not using hormone replacement therapy
• diagnosed with OA in at least one knee in accordance with of the American College of Rheumatology

You may not qualify if:

• no recent knee injury
• no walking aid requirement
• no rehabilitation procedures in the previous three months
• any orthopedic, neurological, respiratory or acute cardiac diseases
• any cognitive deficit as determined by the Mini-Mental State Examination

Sponsors & Collaborators

• Federal University of the Valleys of Jequitinhonha and Mucuri: lead

Related Publications (1)

• Simao AP, Mendonca VA, Avelar NCP, da Fonseca SF, Santos JM, de Oliveira ACC, Tossige-Gomes R, Ribeiro VGC, Neves CDC, Balthazar CH, Leite HR, Figueiredo PHS, Bernardo-Filho M, Lacerda ACR. Whole Body Vibration Training on Muscle Strength and Brain-Derived Neurotrophic Factor Levels in Elderly Woman With Knee Osteoarthritis: A Randomized Clinical Trial Study. Front Physiol. 2019 Jun 25;10:756. doi: 10.3389/fphys.2019.00756. eCollection 2019.

  PMID: 31293437 DERIVED

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Ana Cristina R Lacerda, PhD

  Federal University of the Valleys of Jequitinhonha and Mucuri

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The tests were performed by an experienced examiner who was blind to the group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized, controlled trial in which the variables were assessed 24 h before and 24 h after a 12-week training program. For the allocation of participants, a 1:1 ratio randomization was performed.

Study Record Dates

• First Submitted: April 10, 2019
• First Posted: April 17, 2019
• Study Start: October 28, 2008
• Primary Completion: October 28, 2010
• Study Completion: June 28, 2012
• Last Updated: April 26, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share