NCT03915691

Brief Summary

Atrial tachycardia is a symptomatic arrhythmia, for which an effective treatment is a catheter ablation procedure. The goal of the Ripple AT-Plus study is to evaluate two methods of performing catheter ablation for atrial tachycardia. The main outcome assessed during the study is long-term recurrence of atrial tachycardia following the catheter ablation procedure.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
201

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

3 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 12, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 16, 2019

Completed
3.3 years until next milestone

Study Start

First participant enrolled

August 16, 2022

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2026

Completed
Last Updated

September 25, 2025

Status Verified

September 1, 2025

Enrollment Period

3.6 years

First QC Date

April 12, 2019

Last Update Submit

September 22, 2025

Conditions

Atrial Tachycardia

Keywords

Atrial TachycardiaAtrial FibrillationMappingAblation

Outcome Measures

Primary Outcomes (1)

  • Atrial arrhythmia recurrence

    Any confirmed episode of atrial arrhythmia (\>30 seconds on Holter or 12 lead ECG) occurring in the 12 months after catheter ablation.

    12 months

Secondary Outcomes (5)

  • Acute success during the catheter ablation procedure by the first ablation set.

    Procedure.

  • Acute success during the catheter ablation procedure without the need of entrainment.

    Procedure.

  • Procedure failure.

    Procedure.

  • Total procedure time.

    Procedure.

  • Ablation required

    Procedure.

Study Arms (2)

Isthmus targeted approach using Ripple Mapping

ACTIVE COMPARATOR

Intervention: Isthmus targeted approach using Ripple Mapping catheter ablation of atrial tachycardia.

Procedure: Catheter ablation of atrial tachycardia: Ripple Mapping guided.

Conventional Mapping

ACTIVE COMPARATOR

Intervention: conventional catheter ablation of atrial tachycardia.

Procedure: Catheter ablation of atrial tachycardia: Conventional mapping guided.

Interventions

Catheter ablation of atrial tachycardia: Ripple Mapping guided.PROCEDURE

Ripple Mapping is used to map the atrial tachycardia mechanism. Using the scar thresholding technique the Ripple Map is interpreted and catheter ablation directed to the site of the heart identified as putative to the arrhythmia mechanism. All ablation lesions are confirmed to have conduction block across them using Ripple Mapping. This can include lesions created at previous ablation procedures.

Isthmus targeted approach using Ripple Mapping
Catheter ablation of atrial tachycardia: Conventional mapping guided.PROCEDURE

Conventional activation mapping is used to map the atrial tachycardia mechanism. The resultant (activation) map is interpreted and ablation directed to the site of the heart identified as putative to the arrhythmia mechanism. All ablation lesions are confirmed to have conduction block across them using conventional mapping. This can include lesions created at previous ablation procedures.

Conventional Mapping

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Referred for catheter ablation of AT by the direct care team, based on clinical indication.
  • Male or female, aged \>18 years old.
  • Able to consent for recruitment to the trial and the catheter ablation procedure.

You may not qualify if:

  • Contraindication to catheter ablation as deemed by the clinical team.
  • Typical atrial flutter or AF on ECG.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Liverpool Heart & Chest Hospital

London, L14 3PE, United Kingdom

Location

Imperial College Healthcare NHS Trust

London, W12 0HS, United Kingdom

Location

Freeman Hospital, The Newcastle Upon Tyne NHS Foundation Trust

Newcastle, NE7 7DN, United Kingdom

Location

Related Publications (1)

  • Kailey B, Kemp I, Taylor M, Crooks J, Katritsis G, Koa-Wing M, Jamil-Copley S, Linton N, Kanagaratnam P, Gupta D, Luther V. Ripple AT Plus - isthmus-guided vs conventional ablation in the treatment of scar-related atrial tachycardia: study protocol for a randomised controlled trial. J Interv Card Electrophysiol. 2023 Oct;66(7):1533-1539. doi: 10.1007/s10840-023-01607-8. Epub 2023 Aug 18.

    PMID: 37594646DERIVED

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Vishal Luther, MBBS

    Liverpool Heart & Chest Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 12, 2019

First Posted

April 16, 2019

Study Start

August 16, 2022

Primary Completion

April 1, 2026

Study Completion

April 1, 2026

Last Updated

September 25, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations

GB(3)