Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery

NCT03913299 | Active Not Recruiting

• 2 other identifiers: Frail Heart2019/26FEV/094
• Study Type: observational
• Target: 2,080
• Locations: 1 country
• Sites: 3

Brief Summary

The aim of the study is to assess frailty of patients admited for cardio-vascular surgery in Cliniques Universitaires Saint Luc in Brussels. And analyse the correlation between frailty, functionnal decline and postoperative mortality.

Conditions

Frail Elderly Syndrome; Frailty; Surgery

Keywords

Frailty; Cardiac surgery; Vascular surgery

Outcome Measures

Primary Outcomes (2)

• Mortality

  1 year

• Functionnal decline

  Admission to a nursing home (yes or no) or care dependency (defined by a Katz index higher than 0/6)

  1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients older than 18 years of age admitted for cardiac surgery or vascular surgery in Cliniques Universitaires Saint-Luc in Brussels will be included.

You may qualify if:

• Any cardiac surgery under cardiopulmonary bypass
• Any vascular surgery

You may not qualify if:

• Salvage surgery
• Cirrhosis CHILD B or C

Sponsors & Collaborators

• Cliniques universitaires Saint-Luc- Université Catholique de Louvain: lead

Study Sites (3)

St Luc University Hospital UCLouvain

Brussels, Belgium

Location

Grand Hopital Charleroi

Charleroi, 6060, Belgium

Location

Centre Hospitalier Universitaire de Liège

Liège, 4000, Belgium

Location

Related Publications (18)

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• Bagshaw SM, Stelfox HT, Johnson JA, McDermid RC, Rolfson DB, Tsuyuki RT, Ibrahim Q, Majumdar SR. Long-term association between frailty and health-related quality of life among survivors of critical illness: a prospective multicenter cohort study. Crit Care Med. 2015 May;43(5):973-82. doi: 10.1097/CCM.0000000000000860.

  PMID: 25668751 BACKGROUND

• Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality: A Longitudinal Study. Chest. 2018 Jun;153(6):1378-1386. doi: 10.1016/j.chest.2018.03.007. Epub 2018 Mar 17.

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  PMID: 24651884 BACKGROUND

• Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D, Sibley S, Rockwood K. The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med. 2017 Aug;43(8):1105-1122. doi: 10.1007/s00134-017-4867-0. Epub 2017 Jul 4.

  PMID: 28676896 BACKGROUND

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  PMID: 29165541 BACKGROUND

• Bagshaw M, Majumdar SR, Rolfson DB, Ibrahim Q, McDermid RC, Stelfox HT. A prospective multicenter cohort study of frailty in younger critically ill patients. Crit Care. 2016 Jun 6;20(1):175. doi: 10.1186/s13054-016-1338-x.

  PMID: 27263535 BACKGROUND

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  PMID: 27922747 BACKGROUND

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  PMID: 21378017 BACKGROUND

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  PMID: 16757522 BACKGROUND

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• Reichart D, Rosato S, Nammas W, Onorati F, Dalen M, Castro L, Gherli R, Gatti G, Franzese I, Faggian G, De Feo M, Khodabandeh S, Santarpino G, Rubino AS, Maselli D, Nardella S, Salsano A, Nicolini F, Zanobini M, Saccocci M, Bounader K, Kinnunen EM, Tauriainen T, Airaksinen J, Seccareccia F, Mariscalco G, Ruggieri VG, Perrotti A, Biancari F. Clinical frailty scale and outcome after coronary artery bypass grafting. Eur J Cardiothorac Surg. 2018 Dec 1;54(6):1102-1109. doi: 10.1093/ejcts/ezy222.

  PMID: 29897529 BACKGROUND

MeSH Terms

Conditions

Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Melanie Dechamps, MD

  St Luc University Hospital UCLouvain

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 11, 2019
• First Posted: April 12, 2019
• Study Start: April 23, 2019
• Primary Completion: April 1, 2025
• Study Completion (Estimated): September 30, 2026
• Last Updated: April 15, 2025

Record last verified: 2025-04

Locations

BE (3)