Severe Leptospirosis in Non-tropical Areas
LEPTOREA
1 other identifier
observational
160
1 country
36
Brief Summary
Leptospirosis is a worldwide zoonosis. The mortality of the disease is between 3,6% to 13%, and up to 48% for the severe leptospirosis. Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in intensive care units in Europe. The investigators conduct a retrospective multi centric study in metropolitan France in order to identify the characteristic, the treatments and the prognostic factors associated with mortality of sever leptospirosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2017
36 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 7, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 9, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
July 9, 2018
CompletedFirst Submitted
Initial submission to the registry
April 9, 2019
CompletedFirst Posted
Study publicly available on registry
April 11, 2019
CompletedMay 16, 2019
May 1, 2019
1.2 years
April 9, 2019
May 14, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Mortality at ICU discharge
Mortality was evaluated at ICU discharge
ICU discharge (usually 5 days)
Study Arms (1)
Patient admitted in the ICU for leptospirosis
Patient admitted in the ICU for leptospirosis None intervention was performed according to retrospective design
Eligibility Criteria
All patients admitted in participating ICUs between January 2012 and September 2016 and diagnosed having leptospirosis were included in the study. Patients were identified by searching code A27 in the hospitals databases for International Statistical Classification of Diseases and Related Health Problems, 10th revision
You may qualify if:
- Patient admitted in ICU
- Leptospirosis confirmed with one laboratory test (MAT, ELISA, PCR, direct examination)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (36)
CHU Amiens-Picardie
Amiens, France
CHU Angers
Angers, France
CH Angoulème
Angoulême, France
CH Annecy
Annecy, France
CH Avignon
Avignon, France
hopital saint Leon, CH de la Cote Basque
Bayonne, France
CHU Besançon
Besançon, France
CH Fleyriat
Bourg-en-Bresse, France
CHU de Caen
Caen, France
CH Cahors
Cahors, France
CH Chartres
Chartres, France
CH Cholet
Cholet, France
CHD de la Vendée
La Roche-sur-Yon, France
Hopital Saint Louis
La Rochelle, France
CH Le Mans
Le Mans, France
CH Lens
Lens, France
CHU de Lille
Lille, France
Hopital Edouard Herriot, Hospices civils de Lyon
Lyon, France
GHR MSA
Mulhouse, France
CHRU de Nancy
Nancy, France
CH Niort
Niort, France
CHU Bicetre APHP
Paris, France
CHU Cochin APHP
Paris, France
CHU Henri Mondor
Paris, France
CHU Saint Louis, APHP
Paris, France
CH Périgueux
Périgueux, France
CH René-Dubost
Pontoise, France
CHU Rennes
Rennes, France
CHU Rouen
Rouen, France
CH Saint Brieuc
Saint-Brieuc, France
CH Saint Nazaire
Saint-Nazaire, France
CH Saint Malo
St-Malo, France
CHRU Bretonneau
Tours, France
CH Valenciennes
Valenciennes, France
CH Vannes
Vannes, France
Hopital André Mignot
Versailles, France
Related Publications (4)
Haake DA, Levett PN. Leptospirosis in humans. Curr Top Microbiol Immunol. 2015;387:65-97. doi: 10.1007/978-3-662-45059-8_5.
PMID: 25388133BACKGROUNDPicardeau M. Virulence of the zoonotic agent of leptospirosis: still terra incognita? Nat Rev Microbiol. 2017 May;15(5):297-307. doi: 10.1038/nrmicro.2017.5. Epub 2017 Mar 6.
PMID: 28260786BACKGROUNDDelmas B, Jabot J, Chanareille P, Ferdynus C, Allyn J, Allou N, Raffray L, Gauzere BA, Martinet O, Vandroux D. Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions. Crit Care Med. 2018 Jan;46(1):93-99. doi: 10.1097/CCM.0000000000002825.
PMID: 29116996BACKGROUNDCosta F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015 Sep 17;9(9):e0003898. doi: 10.1371/journal.pntd.0003898. eCollection 2015.
PMID: 26379143BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Jean Reignier, MD, PhD
Nantes University Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 9, 2019
First Posted
April 11, 2019
Study Start
May 7, 2017
Primary Completion
July 9, 2018
Study Completion
July 9, 2018
Last Updated
May 16, 2019
Record last verified: 2019-05
Data Sharing
- IPD Sharing
- Will not share