Interdisciplinary Medication Review Interventions in an Integrated Outpatient Department.

NCT03912103 | Completed DMC

• 1 other identifier: VD-2019-09
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

Inappropriate medication prescribing is highly prevalent among comorbid medical patients and leading to adverse drug events (ADE), re-admissions, quality of life and mortality. Thus, the aim of this study is primary to investigate the feasibility of a interdisciplinary intervention focused on deprescribing and medication optimization in the Integrated Outpatient Department at Copenhagen University Hospital, Amager, Denmark. Participants in the intervention group receives a medication review by a clinical pharmacist and physician with a follow up after 7 and 30 days. The control group receives standard care.

Conditions

Comorbidity; Multimorbidity; Drug Prescribing; Cognitive Impairment; Language Problems

Keywords

Deprescibing; Multimorbidity/comorbidity; Knowledge; Interdiciplinary intervention; Medication information; Motivation

Outcome Measures

Primary Outcomes (1)

• Feasibility of a deprescribing and medication optimization: Number of patients who complete ≥1 deprescribing and/or ≥1 medication optimization 30 days after enrolment in each group.

  Number og patients who complete ≥1 deprescribing and/or ≥1 medication optimization 30 days after enrolment in the study.

  Baseline to 30 days after enrolment

Secondary Outcomes (4)

• Difference in patients between the two groups who completed ≥1 deprescribing and/or dose reduction 30 days after enrolment. Difference as %.

  Baseline to 30 days after enrolment

• Difference in patients between the two groups who completed ≥1 medication optimization 30 days after enrolment in each group. Difference as %

  Baseline to 30 days after enrolment

• Difference in Knowledge between the two groups who gains more knowledge about their medication measured by ≥1 point on Likert scale (1-5 p).

  Baseline to 14 days after enrolment

• Difference in patients who are satisfied with medication information measured by ≥1 point on Likert scale (1-5 p).

  Baseline to 14 days after enrolment

Study Arms (2)

Interdiciplinary medication review intervention

ACTIVE COMPARATOR

The clinical pharmacist perform medication review and presents medication interventions orally and written to the physician. The physician perform the changes and inform the patient about the changes. 7 days after intervention the patient receives a follow up phone call from the pharmacist about the medication interventions. If the pharmacist during the follow up phone call identify any complications due to compliance/add on/deprescribing the pharmacist uses motivational conversation to come to a solution.14 days after the beginning of the intervention the patients knowledge about their medication and satisfaction with medication information is investigated by a phone questionnaire and measured on a Likert scale (1-5). 30 days after the beginning of the intervention the pharmacist collect an updated medication history. Finally we investigate the number of patients who have completed at least one deprescribing and/or medication optimization in each group.

Other: Interdisciplinary Deprescribing and Medication Optimization Intervention

Control group

NO INTERVENTION

Standard treatment without a medication review and follow up related to medication changes (standard treatment).14 days after the enrollment the patients knowledge about their medication and satisfaction with medication information is investigated by a phone questionnaire measured on a Likert scale (1-5). 30 days after the enrollment the pharmacist collect an updated medication history.Finally we investigate the number of patients who have completed at least one deprescribing and/or medication optimization in each group

Interventions

Interdisciplinary Deprescribing and Medication Optimization Intervention OTHER

as current

Interdiciplinary medication review intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Consultation at Integrated Outpatient Department subacute track
• Multi morbidity/Comorbidity
• Drug Prescribing
• Mentally fresh
• Understand and speak Danish

You may not qualify if:

• Unable to cooperate cognitively
• Language problems
• Admission

Sponsors & Collaborators

• Region Hovedstadens Apotek: lead
• Copenhagen University Hospital, Hvidovre: collaborator

Study Sites (1)

Capital Regional Hospital, Amager, Integrated Outpatient Department

Copenhagen, 2300, Denmark

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Helle Ø McNulty, cand pharm

  Region Hovedstadens Apotek

  STUDY DIRECTOR

• Charlotte Treldal, Phd

  Region Hovedstadens Apotek

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The evaluation of completed deprescribing and/or medication optimization are performed by two blinded assessors (senior clinical pharmacist and/or medical physicians).
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical pharmacist

Model Details: Interdisciplinary medicine intervention focused on deprescribing and medication optimization. The control group receives standard care. Finally we investigate the number of patients who have completed at least one deprescribing and/or medication optimization in each group.

Study Record Dates

• First Submitted: April 8, 2019
• First Posted: April 11, 2019
• Study Start: March 19, 2019
• Primary Completion: December 30, 2019
• Study Completion: March 5, 2021
• Last Updated: April 13, 2021

Record last verified: 2019-03

Locations

DK (1)