Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
1 other identifier
observational
200
1 country
1
Brief Summary
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2022
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 25, 2019
CompletedFirst Posted
Study publicly available on registry
April 10, 2019
CompletedStudy Start
First participant enrolled
June 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2030
August 15, 2025
August 1, 2025
8.5 years
March 25, 2019
August 11, 2025
Conditions
Outcome Measures
Primary Outcomes (9)
Changes in airways over time
Measured using Xenon-129 (129-Xe) MRI
3 years
Changes in parenchyma over time
Measured using Xenon-129 (129-Xe) MRI
3 years
Differences in lung ventilation in cannabis smokers compared to never-smokers and tobacco smokers
Measured using 129-Xe MRI
3 years
Differences in perfusion in cannabis smokers compared to never-smokers and tobacco smokers
Measured using 129-Xe MRI
3 years
Differences in parenchyma integrity in cannabis smokers compared to never-smokers and tobacco smokers
Measured using 129-Xe MRI
3 years
Differences in airways between cannabis-only smokers and cannabis and tobacco smokers
Measured using 129-Xe MRI
3 years
Differences in parenchyma between cannabis-only smokers and cannabis and tobacco smokers
Measured using 129-Xe MRI
3 years
Dose-response of cannabis use to changes in airways over time
Measured using 129-Xe MRI
3 years
Dose-response of cannabis use to changes in parenchyma over time
Measured using 129-Xe MRI
3 years
Study Arms (1)
Cannabis Smoker
Participants in this group will be current or former cannabis smokers
Interventions
Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas
Participants will undergo a CT scan of the thoracic cavity
Participants will have their lung function evaluated using PFTs
Participants \>35 years of age will perform the six minute walk test as a measure of exercise capacity
Participants \<35 will perform cardiopulmonary exercise testing as a measure of exercise capacity
Participants will provide a sputum sample that will be analysed for eosinophils
Participants will have their blood drawn and analysed for eosinophil count.
Eligibility Criteria
Current and former smokers of cannabis
You may qualify if:
- Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature
- Provision of written, informed consent prior to any study specific procedures
- Males and females aged 18-85
- Current or former cannabis smoker (medicinal or recreational) with or without concurrent tobacco smoking history
- Participant is able to perform reproducible pulmonary function testing (i.e. the 3 best acceptable spirograms have Forced Expiratory Volume in 1 second (FEV1) values that do not vary more than 150 millilitres)
- Participant is able to perform a breathhold for 16s
- FEV1 \> 25% predicted
- Forced Vital Capacity (FVC) \> 25% predicted and \>0.5 litres
You may not qualify if:
- Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material
- Participant is medically unstable in the opinion of the Principal Investigator
- Participant has a daytime room air oxygen saturation \<90% while lying supine
- Participant is unable to perform spirometry or plethysmography maneuvers
- Patient is pregnant at time of enrolment
- In the opinion of the investigator, patient suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia
- Patient has implanted mechanically, electrically or magnetically activated device or any metal in their body, which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants) - at the discretion of the MRI Technologist.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Ontario, N6A 5B7, Canada
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Grace E Parraga, PhD
Robarts Research Institute, The University of Western Ontario
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 25, 2019
First Posted
April 10, 2019
Study Start
June 1, 2022
Primary Completion (Estimated)
December 1, 2030
Study Completion (Estimated)
December 1, 2030
Last Updated
August 15, 2025
Record last verified: 2025-08