Non-interventional Study on Patients With Atrial Fibrillation and Cancer
BLITZ-AFCancer
Multicenter, Non-interventional Study on Patients With Atrial Fibrillation (AF) and Cancer (Diagnosed Within the Last 3 Years Prior to Enrolment)
1 other identifier
observational
1,514
6 countries
147
Brief Summary
AF and cancer frequently coexist. Since these patients are usually excluded from randomized trials, information on their management and outcome is scarce. Occurrence of relevant clinical events, such as ischemic and hemorrhagic and all-cause mortality and cardiovascular (CV) mortality occurring in patients treated or not with antithrombotic agents needs to be clarified. A prospective observational registry collecting information, in a real world setting, on the clinical profile of patients with these clinical conditions and on the use of antithrombotic drugs in patients with AF and cancer could improve our knowledge on the management of these high risk patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2019
Typical duration for all trials
147 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 5, 2019
CompletedFirst Posted
Study publicly available on registry
April 10, 2019
CompletedStudy Start
First participant enrolled
June 26, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2022
CompletedJanuary 12, 2023
January 1, 2023
2.3 years
April 5, 2019
January 11, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Patients with AF and cancer treated with oral anticoagulant therapy and with other antithrombotic therapy
Number of patients with AF and cancer treated with oral anticoagulant therapy and with other antithrombotic therapy
Baseline
Patients with AF and cancer treated with oral anticoagulant therapy and with other antithrombotic therapy
Number of patients with AF and cancer treated with oral anticoagulant therapy and with other antithrombotic therapy
12 Months
Secondary Outcomes (19)
Patients treated with oral anticoagulant therapy, other antithrombotic therapy or not treated experiencing all cause stroke
Baseline and 12 months
Patients treated with oral anticoagulant therapy, other antithrombotic therapy or not treated experiencing transient ischemic attacks
Baseline and 12 months
Patients treated with oral anticoagulant therapy, other antithrombotic therapy or not treated experiencing major adverse cardiovascular events (non fatal MI, non fatal stroke, non fatal systemic embolic events, cardiovascular death)
Baseline and 12 months
Patients treated with oral anticoagulant therapy, other antithrombotic therapy or not treated experiencing systemic embolic events
Baseline and 12 months
Patients treated with oral anticoagulant therapy, other antithrombotic therapy or not treated experiencing acute coronary syndrome
Baseline and 12 months
- +14 more secondary outcomes
Eligibility Criteria
Patient with diagnosed AF (any type of AF, electrocardiographically documented within 1 year prior to enrolment) and with a documented cancer (diagnosed within the last 3 years prior to enrolment into this registry), including melanoma but not other basal-cell or squamous-cell carcinoma of the skin. The diagnosis/history of cancer must be objectively documented.
You may qualify if:
- Both sexes
- Age \>18 years
- Patient with diagnosed AF (any type of AF, electrocardiographically documented within 1 year prior to enrolment)
- Patient with a documented cancer (diagnosed within the last 3 years prior to enrolment into this registry), including melanoma but not other basal-cell or squamous-cell carcinoma of the skin. The diagnosis/history of cancer must be objectively documented.
- Written informed consent (IC) for participation in the study
- Patient not simultaneously participating in any interventional study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (147)
OLV ZIEKENHUIS AALST - Cardiology
Aalst, Belgium
AZ IMELDA - Cardiology
Bonheiden, Belgium
AZ ST-JAN - Cardiology
Bruges, Belgium
Hôpital Erasme - Cardiology
Brussels, Belgium
UCL Cliniques universitaires Saint-Luc - Cardiolgy
Brussels, Belgium
UZ Brussel - Cardiology
Brussels, Belgium
Ziekenhuis Oost-Limburg - Cardiology
Genk, Belgium
JESSA HASSELT - Cardiology
Hasselt, Belgium
AZ GROENINGE - Cardiology
Kortrijk, Belgium
UZ LEUVEN - Cardiovascular diseases
Leuven, Belgium
AZ DELTA ROESELARE - Cardiology
Roeselare, Belgium
AZ TURNHOUT - Cardiology
Turnhout, Belgium
Bon Secours Hospital Cork - Oncology Department
Cork, Ireland
Beacon Hospital, Cardiology
Dublin, Ireland
Tallaght University Hospital - Geriatric and Stroke Medicine Department
Dublin, Ireland
Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic
Agrigento, AG, 92100, Italy
Ospedale Barone Lombardo - Cardiologia E Utic
Canicattì, AG, 92024, Italy
Ospedale Santo Spirito - Sc Cardiologia
Casale Monferrato, AL, 15033, Italy
Ospedale Civile Profili - U.O. Cardiologia
Fabriano, AN, 60044, Italy
Ospedale San Donato - U.O. Cardiologia
Arezzo, AR, 52100, Italy
Ospedale San Paolo - Cardiologia-Utic
Bari, BA, 70123, Italy
Istituto Tumori Giovanni Paolo Ii - U.O. Di Cardiologia
Bari, BA, 70124, Italy
Ospedali Treviglio-Caravaggio - Cardiologia
Treviglio, BG, 24047, Italy
Ospedale Civile - Sc Cardiologia
Belluno, BL, 32100, Italy
Ospedale Santa Maria Del Prato - U.O. Di Cardiologia
Feltre, BL, 32032, Italy
Ospedale Maggiore - U.O. Di Cardiologia
Bologna, BO, 40133, Italy
Ospedale Policlinico S. Orsola-Malpighi - U.O. Cardiologia-Rapezzi
Bologna, BO, 40138, Italy
Ospedale Bellaria - U.O. Di Cardiologia
Bologna, BO, 40139, Italy
Ospedale A. Businco - Servizio Di Cardiologia
Cagliari, CA, 09121, Italy
Ospedale Roberto Binaghi - Servizio Di Cardiologia
Cagliari, CA, 09126, Italy
Az. Ospedaliera S. Anna E S. Sebastiano - Cardiologia Clinica Universitaria - Utic
Caserta, CE, 81100, Italy
Ospedale San Giuseppe E Melorio - U.O.C. Cardiologia Utic
Santa Maria Capua Vetere, CE, 81055, Italy
Ospedale Regina Montis Regalis - U.O. Cardiologia-Utic
Mondovì, CN, 12084, Italy
Ospedale Maggiore Ss. Annunziata - Sc Cardiologia
Savigliano, CN, 12038, Italy
Ospedale Civile Ferrari - U.O.C. Cardiologia-Utic
Castrovillari, CS, 87012, Italy
Ospedale Spoke Paola- Cetraro Po Paola - Utic Cardiologia
Paola, CS, 87027, Italy
P.O. Garibaldi-Nesima - U.O.C. Di Cardiologia
Catania, CT, 95122, Italy
Azienda Ospedaliera Cannizzaro - Uoc Cardiologia Con Utic Ed Emodinamica
Catania, CT, 95126, Italy
Humanitas Centro Catanese Di Oncologia - Servizio Di Cardiologia
Catania, CT, 95126, Italy
Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic
Foggia, FG, 71100, Italy
Ospedale Civile San Giuseppe - Cardiologia
Empoli, FI, 50053, Italy
Ospedale San Giovanni Di Dio - Cardiologia
Florence, FI, 50124, Italy
Aou Careggi - Cardiologa Diagnostica
Florence, FI, 50134, Italy
Aou Careggi - Diagnostica Cardiovascolare
Florence, FI, 50139, Italy
Ospedale Policlinico San Martino - Clinica Malattie Cardiovascolari
Genova, GE, 16132, Italy
Ospedale Padre Antero Micone - Sc Cardiologia - Utic
Genova, GE, 16153, Italy
Ospedale San Giuseppe Da Copertino - U.O. Di Cardiologia-Utic
Copertino, LE, 73043, Italy
Ospedale Ignazio Veris Delli Ponti - Uoc Cardiologia-Utic
Scorrano, LE, 73020, Italy
Nuovo Ospedale Versilia - Sc Cardiologia
Lido di Camaiore, LU, 55043, Italy
Policlinico G. Martino - U.O. Medicina Interna
Messina, ME, 98124, Italy
Istituto Nazionale Tumori - Struttura Complessa Di Cardiologia
Milan, MI, 20133, Italy
Istituto Europeo Di Oncologia - Cardiologia
Milan, MI, 20141, Italy
Asst Ospedale Metropolitano Niguarda - Cardiologia 4 -Diagnost. E Riabilitativa
Milan, MI, 20162, Italy
Ospedale Di Vizzolo Predabissi - Uo Cardiologia E Ucc
Vizzolo Predabissi, MI, 20077, Italy
Ospedale Ramazzini - U.O. Cardiologia
Carpi, MO, 41013, Italy
Ospedale Di Sassuolo - Cardiologia
Sassuolo, MO, 41049, Italy
Ospedale San Francesco - Cardiologia - Utic
Nuoro, NU, 08100, Italy
Fondazione G. Giglio - U.O. Cardiologia E Utic
Cefalù, PA, 90015, Italy
Aor Villa Sofia-Cervello P.O. Cervello, Uo Cardiologia - Cervello
Palermo, PA, 90146, Italy
Istituto Oncologico Veneto - Cardiologia Oncologica
Padua, PD, 35128, Italy
Ospedale Civile Dello Spirito Santo - Utic E Cardiologia Interventistica
Pescara, PE, 65124, Italy
Azienda Ospedaliera Universitaria Pisana - U.O. Malattie Cardiovasc. I - Cisanello
Pisa, PI, 26124, Italy
Centro Di Riferimento Oncologico (Cro) - Cardiologia
Aviano, PN, 33081, Italy
Presidio Ospedaliero San Salvatore - Cardiologia E Utic
Pesaro, PU, 61121, Italy
Fondazione Irccs Policlinico San Matteo - Cardiologia
Pavia, PV, 27100, Italy
Ics Maugeri Spa Societa' Benefit - U.O. Di Riabilitazione Cardiologica
Pavia, PV, 27100, Italy
Ospedale Civile Santa Maria Delle Croci - U.O. Di Cardiologia
Ravenna, RA, 48100, Italy
Ospedale Santa Maria Degli Ungheresi - Uoc Cardiologia-Utic
Polistena, RC, 89024, Italy
Grande Ospedale Metropolitano-Bianchi Melacrino Morelli - Divisione Di Cardiologia
Reggio Calabria, RC, 89124, Italy
Ospedale Civile - Sc Cardiologia Area Nord
Guastalla, RE, 42016, Italy
Arcispedale Santa Maria Nuova - S.C. Cardiologia
Reggio Emilia, RE, 42100, Italy
Ospedale Giovanni Paolo Ii - U.O.C. Cardiologia-Utic
Ragusa, RG, 97100, Italy
Nuovo Ospedale Dei Castelli - U.O.C. Di Cardiologia E Utic
Ariccia, RM, 00072, Italy
Campus Biomedico - Cardiologia
Roma, RM, 00128, Italy
P.O. San Filippo Neri - Asl Roma 1 - Uoc Cardiologia E Utic
Roma, RM, 00135, Italy
Ospedale San Camillo - Uosd Servizi Cardiologici Integrati
Roma, RM, 00151, Italy
Ifo- Istituto Naz. Tumori Regina Elena - Uo Cardiologia
Roma, RM, 00152, Italy
Policlinico Agostino Gemelli - Uo Cardiologia Per Sc E Riab. Cardiolog.
Roma, RM, 00168, Italy
Ospedale G. Ceccarini - Cardiologia-Utic
Riccione, RN, 47838, Italy
Aou S. Giovanni Di Dio-Ruggi D'Aragona - Cardiologia Intensiva
Salerno, SA, 84131, Italy
Ospedale Dell'Alta Val D'Elsa - Uosd Cardiologia-Utic
Poggibonsi, SI, 53036, Italy
Ospedale San Bartolomeo - U.O. Cardiologia Clinica-Riabilitativa
Sarzana, SP, 19038, Italy
Ospedale E. Muscatello - U.O. Di Cardiologia - Utic
Augusta, SR, 96011, Italy
Ospedale Di Castellaneta - S.C. Cardiologia
Castellaneta, TA, 74011, Italy
Ospedale Civile M. Giannuzzi - Cardiologia E Utic
Manduria, TA, 74024, Italy
Presidio Ospedaliero Della Valle D'Itria - Struttura Complessa Di Cardiologia
Martina Franca, TA, 74015, Italy
Ospedale Civile G. Mazzini - Cardiologia Utic Ed Emodinamica
Teramo, TE, 64100, Italy
Ospedale Santa Maria Del Carmine - Cardiologia
Rovereto, TN, 38068, Italy
Ospedale San Luigi Gonzaga - S.C.D.O. Cardiologia
Orbassano, TO, 10043, Italy
Ospedale Civile E. Agnelli - Sc Di Cardiologia
Pinerolo, TO, 10064, Italy
Ospedale Degli Infermi, Sc Cardiologia
Rivoli, TO, Italy
Aou Citta' Della Salute E Della Scienza - S.C.D.U. Cardiologia
Torino, TO, 10126, Italy
Ospedale Mauriziano Umberto I - Sc Cardiologia
Torino, TO, 10128, Italy
Ospedale Humanitas Gradenigo - Cardiologia
Torino, TO, 10153, Italy
Ospedale Giovanni Bosco - Sc Cardiologia
Torino, TO, 10155, Italy
Ospedale Ss. Vito E Spirito - U.O.S. Di Cardiologia
Alcamo, TP, 91011, Italy
Azienda Ospedaliera Santa Maria - S.C. Di Cardiologia
Terni, TR, 05100, Italy
Asui Trieste - S.C. Centro Cardiovascolare
Trieste, TS, 34125, Italy
Pou Santa Maria Della Misericordia - S.O.C. Cardiologia
Udine, UD, 33100, Italy
Presidio Ospedaliero Di Saronno - U.O.C. Di Cardiologia
Saronno, VA, 21047, Italy
Ospedale Civile - U.O. Cardiologia
Mirano, VE, 30035, Italy
Ospedale Civile - U.O.C. Cardiologia
Arzignano, VI, 36071, Italy
Ospedale Sacro Cuore - U.O. Di Cardiologia
Negrar, VR, 37024, Italy
Ospedale Miulli - U.O.C. Cardiologia - Utic
Acquaviva delle Fonti, Italy
Ospedale Ss. Trinita' - S.C. Di Cardiologia
Borgomanero, 28021, Italy
Az. Ospedaliera S. Anna E S. Sebastiano - Uoc Medicina E Chirurgia D'Urgenza
Caserta, Italy
Ospedale Policlinico Ss. Annunziata - Medicina Generale Ii
Chieti, Italy
Arcispedale Sant'Anna - U.O. Cardiologia - Utic
Ferrara, Italy
Ospedale Generale Di Zona - U.O. Cardiologia - Utic
Giugliano in Campania, 80014, Italy
Fondazione Pascale - S.C. Cardiologia
Napoli, 80131, Italy
Ospedale San Gennaro - U.O. Cardiologia E Riabilitazione Card.
Napoli, 80136, Italy
Aou Maggiore Della Carita' - Cardiologia Ii
Novara, 28100, Italy
Ospedale Ss. Cosma E Damiano - U. O. Cardiologia - Utic
Pescia, Italy
Ospedale Santa Maria Delle Grazie - U.O. Cardiologia - Utic
Pozzuoli, 80078, Italy
Ospedale Sandro Pertini, Uoc Cardiologia
Roma, Italy
Jeroen Bosch Ziekenhuis - Research Cardiologie
's-Hertogenbosch, Netherlands
Rijnstate Ziekenhuis - Afdeling Cardioresearch
Arnhem, Netherlands
Tergooi - Poli cardiologie / poli 2
Blaricum, Netherlands
Amphia Ziekenhuis - Research Cardiologie
Breda, Netherlands
Martini Ziekenhuis - Dept. Cardio Research Noord BV
Groningen, Netherlands
Diakonessenhuis - Research Cardiologie
Utrecht, Netherlands
University Medical Center Utrecht - Cardiologie
Utrecht, Netherlands
Máxima Medisch Centrum - Poli Cardiologie
Veldhoven, Netherlands
Prof. Doutor Fernando Fonseca EPE Hospital, Cardiologia
Amadora, Portugal
Hospital Nossa Senhora do Rosário, Cardiology
Barreiro, Portugal
Hospital da Luz
Lisbon, Portugal
Hospital de Santa Cruz, Cardiology
Lisbon, Portugal
Hospital Santa Maria, Cardiology
Lisbon, Portugal
Hospital del Mar (Parc de Salut Mar),Cardiologa I Unitat Coronaria
Barcelona, Spain
Hospital Médico-Quirúrgico, Cardiology
Jaén, Spain
Clínica Anderson, Oncología Médica
Madrid, Spain
Clínica Medicentro, Cardiología
Madrid, Spain
Hopsital Puerta de Hierro
Madrid, Spain
Hospital La Moraleja, Servicio de Cardiología
Madrid, Spain
Hospital La Paz
Madrid, Spain
Hospital La Zarzuela
Madrid, Spain
Hospital Montepríncipe, Cardiología
Madrid, Spain
Hospital Ramón y Cajal
Madrid, Spain
Hospital Rúber Internacional, Oncología
Madrid, Spain
Hospital Universitario Gregorio Marañón, Servicio de Cardiología
Madrid, Spain
Hospital Virgen de Arrixaca - Cardiologia
Murcia, Spain
Hospital de Salamanca, Cardiología
Salamanca, Spain
Hospital Universitario Virgen Macarena, Cardiologia
Seville, Spain
Hospital de Torrejón
Torrejón de Ardoz, Spain
Hospital Universitario Río Hortega, Cardiología
Valladolid, Spain
University Clinical Hosp. de Valladolid, Cardiología
Valladolid, Spain
Hospital Clínico "Lozano Blesa", Cardiologia
Zaragoza, Spain
Related Publications (1)
Gulizia MM, Turazza FM, Ameri P, Alings M, Collins R, De Luca L, Di Nisio M, Lucci D, Gabrielli D, Janssens S, Parrini I, Pinto FJ, Zamorano J, Colivicchi F; BLITZ-AF Cancer Investigators. Characteristics and Management of Patients With Cancer and Atrial Fibrillation: The BLITZ-AF Cancer Registry. JACC Adv. 2024 May 24;3(7):100991. doi: 10.1016/j.jacadv.2024.100991. eCollection 2024 Jul.
PMID: 39130025DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Michele M Gulizia, MD
Heart Care Foundation
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 5, 2019
First Posted
April 10, 2019
Study Start
June 26, 2019
Primary Completion
September 30, 2021
Study Completion
September 30, 2022
Last Updated
January 12, 2023
Record last verified: 2023-01